Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells

1995 ◽  
Vol 98 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Masaki Sazuka ◽  
So Murakami ◽  
Mamoru Isemura ◽  
Ken Satoh ◽  
Toshihiro Nukiwa
Keyword(s):  
Green Tea ◽  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Inhibitory Effects ◽  
Tea Infusion ◽  
Lung Carcinoma Cells ◽  
In Vitro Invasion

Inhibitory Effects of Green Tea Infusion on In Vitro Invasion and In Vivo Metastasis of Mouse Lung Carcinoma Cells

1997 ◽  
pp. 134-137 ◽  
Author(s):  
Mamoru Isemura ◽  
Masaki Sazuka ◽  
Hirokazu Imazawa ◽  
Tsutomu Nakayama ◽  
Tadataka Noro ◽  
...  
Keyword(s):  
Green Tea ◽  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Inhibitory Effects ◽  
Tea Infusion ◽  
Lung Carcinoma Cells ◽  
In Vitro Invasion

Inhibitory Effects of Tetragalloylglucose and Digalloylhamamelose on Adhesion and in vitro Invasion of Mouse Lung Carcinoma Cells

Planta Medica ◽  
1999 ◽  
Vol 65 (3) ◽  
pp. 227-229 ◽  
Author(s):  
Kouichi Saeki ◽  
Yutaka Shoji ◽  
Tadataka Noro ◽  
Toshio Miyase ◽  
Yoshiyuki Nakamura ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Inhibitory Effects ◽  
Lung Carcinoma Cells ◽  
In Vitro Invasion

DMNQ S-53 induces apoptosis and inhibits the growth of Lewis lung carcinoma cells in vitro and in vivo

2006 ◽  
Vol 1 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Jae-Ho Lee ◽  
Eun-Ok Lee ◽  
Hyo-Jung Lee ◽  
Kwan-Hyun Kim ◽  
Kyoo-Seok Ahn ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lewis Lung ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

scholarly journals Nanocomplex of Berberine with C60 Fullerene Is a Potent Suppressor of Lewis Lung Carcinoma Cells Invasion In Vitro and Metastatic Activity In Vivo

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6114
Author(s):  
Iryna Horak ◽  
Svitlana Prylutska ◽  
Iryna Krysiuk ◽  
Serhii Luhovskyi ◽  
Oleksii Hrabovsky ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Carcinoma Cells ◽  
C60 Fullerene ◽  
Lewis Lung ◽  
Invasion Potential ◽  
Lung Carcinoma Cells ◽  
Lewis Lung Carcinoma Cells

Effective targeting of metastasis is considered the main problem in cancer therapy. The development of herbal alkaloid Berberine (Ber)-based anticancer drugs is limited due to Ber’ low effective concentration, poor membrane permeability, and short plasma half-life. To overcome these limitations, we used Ber noncovalently bound to C60 fullerene (C60). The complexation between C60 and Ber molecules was evidenced with computer simulation. The aim of the present study was to estimate the effect of the free Ber and C60-Ber nanocomplex in a low Ber equivalent concentration on Lewis lung carcinoma cells (LLC) invasion potential, expression of epithelial-to-mesenchymal transition (EMT) markers in vitro, and the ability of cancer cells to form distant lung metastases in vivo in a mice model of LLC. It was shown that in contrast to free Ber its nanocomplex with C60 demonstrated significantly higher efficiency to suppress invasion potential, to downregulate the level of EMT-inducing transcription factors SNAI1, ZEB1, and TWIST1, to unblock expression of epithelial marker E-cadherin, and to repress cancer stem cells-like markers. More importantly, a relatively low dose of C60-Ber nanocomplex was able to suppress lung metastasis in vivo. These findings indicated that сomplexation of natural alkaloid Ber with C60 can be used as an additional therapeutic strategy against aggressive lung cancer.

scholarly journals Efficacy of Combination Treatment and Influence of Schedule with Irinotecan and Amrubicin in Human Lung Carcinoma Cells in Vivo and in Vitro

2010 ◽  
Vol 33 (7) ◽  
pp. 1183-1191 ◽  
Author(s):  
Yoshiyuki Shishido ◽  
Tomio Furuta ◽  
Takeshi Matsuzaki ◽  
Hiroshi Nagata ◽  
Shusuke Hashimoto
Keyword(s):  
Lung Carcinoma ◽  
Combination Treatment ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma

scholarly journals Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins

1997 ◽  
Vol 61 (9) ◽  
pp. 1504-1506 ◽  
Author(s):  
Masaki Sazuka ◽  
Hirokazu Imazawa ◽  
Yutaka Shoji ◽  
Takashi Mita ◽  
Yukihiko Hara ◽  
...  
Keyword(s):  
Green Tea ◽  
Lung Carcinoma ◽  
Black Tea ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Lung Carcinoma Cells

scholarly journals Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhicheng Wang ◽  
Yumin Li ◽  
Tong Zhang ◽  
Hongxia Li ◽  
Zhao Yang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Drug Loading ◽  
Complexation Reaction ◽  
Lewis Lung ◽  
Antitumor Effects ◽  
Lung Carcinoma Cells

Insufficient transport of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Block copolymers are promising carriers with smaller particle size by ratio modification. Here, we constructed cisplatin nanoparticles with sizes ranging from 8 to 40 nm to study the permeability and therapy of Lewis lung carcinoma. We synthesized methoxypoly(ethylene glycol)2000-block poly(L-glutamic acid sodium salt)1979 loading cisplatin through complexation reaction. The cisplatin nanomedicine has high drug loading and encapsulation efficiency. In vitro data demonstrated that cisplatin nanoparticles had equivalent growth-inhibiting effects on Lewis lung carcinoma cells compared to free cisplatin. In vivo evidences showed cisplatin nanoparticles had superior antitumor effects on the Lewis lung carcinoma mouse model with no obvious side effects. All results indicated that optimizing the ratio of block copolymers to obtain smaller sized nanomedicine could act as a promising strategy for overcoming the inadequate accumulation in poorly vascularized tumors.

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