Tissue-specific association of the human tyrosine hydroxylase gene with the nuclear matrix

2002 ◽  
Vol 330 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Robert Lenartowski ◽  
Anna Goc
Keyword(s):  
Tyrosine Hydroxylase ◽  
Nuclear Matrix ◽  
Tissue Specific ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene ◽  
Specific Association

Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice

Neuron ◽  
1991 ◽  
Vol 6 (4) ◽  
pp. 583-594 ◽  
Author(s):  
Norio Kaneda ◽  
Toshikuni Sasaoka ◽  
Kazuto Kobayashi ◽  
Kazutoshi Kiuchi ◽  
Ikuko Nagatsu ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Transgenic Mice ◽  
High Level Expression ◽  
Tissue Specific ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene ◽  
High Level

Induction of Tyrosine Hydroxylase Gene Expression in Embryonal Carcinoma Stem Cells Using a Natural Tissue‐Specific Inducer

2019 ◽  
Vol 79 (6) ◽  
pp. 559-577
Author(s):  
Nazila Momendoust ◽  
Jamal Moshtaghian ◽  
Fariba Esmaeili ◽  
Fariba Dehghanian ◽  
Veronica Dumit
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Tyrosine Hydroxylase ◽  
Embryonal Carcinoma ◽  
Tissue Specific ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene ◽  
Natural Tissue

scholarly journals The bovine tyrosine hydroxylase gene associates in vitro with the nuclear matrix by its first intron sequence.

2003 ◽  
Vol 50 (3) ◽  
pp. 865-873 ◽  
Author(s):  
Robert Lenartowski ◽  
Tomasz Grzybowski ◽  
Danuta Miścicka-Sliwka ◽  
Waldemar Wojciechowski ◽  
Anna Goc
Keyword(s):  
Tyrosine Hydroxylase ◽  
Nuclear Matrix ◽  
Matrix Attachment Region ◽  
Binding Potential ◽  
Computer Search ◽  
Intron Sequence ◽  
Tyrosine Hydroxylase Gene ◽  
First Intron ◽  
Hydroxylase Gene

Recently we have shown that in vitro binding of the proximal part of the human tyrosine hydroxylase gene to the nuclear matrix is correlated with its transcriptional activity. The strongest binding potential was predicted by computing for the first intron sequence (Lenartowski & Goc, 2002, Neurosci Lett.; 330: 151-154). In this study a 16 kb fragment of the bovine genomic DNA containing the tyrosine hydroxylase gene was investigated for its affinity to the nuclear matrix. Only a 950 bp fragment encoding the distal part of the first intron, second exon and a few nucleotides of the second intron bound to the nuclear matrix. The binding was independent of the tissue-specific tyrosine hydroxylase gene activation. The fragment was subcloned and sequenced. Computer search pointed to one potential intronic matrix attachment region with two AP1-like sites embedded in the sequence. We conclude that even if the position of the matrix binding region is conserved among the tyrosine hydroxylase genes in mammals, its tissue specificity and/or function is not preserved or is achieved by different mechanisms.

scholarly journals The tissue-specific methylation of the human Tyrosine Hydroxylase gene reveals new regulatory elements in the first exon

2005 ◽  
Vol 94 (1) ◽  
pp. 129-139 ◽  
Author(s):  
Tamas Aranyi ◽  
Baptiste A. Faucheux ◽  
Olfa Khalfallah ◽  
Guilan Vodjdani ◽  
Nicole Faucon Biguet ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Regulatory Elements ◽  
Tissue Specific ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene

P.6.c.006 Association between the tyrosine hydroxylase gene and patients with methamphetamine dependence

2012 ◽  
Vol 22 ◽  
pp. S401-S402
Author(s):  
Y. Okahisa ◽  
M. Kishimoto ◽  
S. Sakamoto ◽  
Y. Mizuki ◽  
M. Takaki ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Tyrosine Hydroxylase Gene ◽  
Hydroxylase Gene ◽  
Methamphetamine Dependence
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