Place de la corticothérapie inhalée dans la prévention du remodelage bronchique. Controverse : contreCorticosteroid inhalation therapy for the prevention of bronchial remodelling: arguments against

60 patients with chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) were examined in the dynamics of treatment. The complex therapy of patients with COPD and CP including inhalation therapy with Thiotropium bromide, Serrathiopeptidase and Emoxypin promoted reduced intensity of oxidative stress, restoration of antioxidant protective components activity and natural detoxication system, intensified the activity of enzymatic, Hagemmandependant fibrinolysis and collagenosis, improving the processes of microcirculation, elimination of ischemia and swelling of the pancreatic tissue, quick removal of clinical exacerbation signs of the underlying disease and comorbid diseases. According to the correction degree of enzyme deviation syndrome in the blood, intensity of nitrositic stress and endogenic intoxication in patients with COPD and CP, the effect of 30-day intake of Serrathiopeptidase and 15-day intake of Emoxypin is equal to the efficacy of five plasmapheresis sessions.

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Computational Study of Atomization Models and Optimal Design of a Pressurized Inhaler

Journal of Biomimetics Biomaterials and Biomedical Engineering ◽

10.4028/www.scientific.net/jbbbe.50.123 ◽

2021 ◽

Vol 50 ◽

pp. 123-134

Author(s):

Anurag Tiwari ◽

Siddharth Sharma ◽

Vivek Kumar Srivastav ◽

Anuj Jain ◽

Akshoy Ranjan Paul

Keyword(s):

Drug Delivery ◽

Particle Production ◽

Computational Study ◽

Nozzle Diameter ◽

Inhalation Therapy ◽

Respiratory Drug Delivery ◽

Minimum Diameter ◽

Inhaler Device ◽

Swirl Atomizer ◽

Pressure Swirl

Respiratory drug delivery has been under the spotlight of research for the past few decades, mainly due to rapid increase of pulmonary diseases. This type of drug delivery offers the highest efficiency for treatment. Despite its numerous benefits, there are some drawbacks in the method of respiratory drug delivery-the most important being poor delivery efficiency and high drug deposition in undesirable regions, such as the oropharynx. This study is focused on improving pressurized inhaler device, which is one of the most used devices for inhalation therapy throughout the world using the results and findings obtained from numerical analysis. In this study, three atomizer models are investigated and found that pressure swirl atomizer model closely represents the atomization phenomenon from a pressurized inhaler device. Parametric study is carried out using three parameters: nozzle diameter, dispersion angle and sheet constant to optimize the performance of the device. It is revealed that a reduction in nozzle diameter and dispersion angle help in generating fine (smaller diameter) particles, whereas increase in sheet constant is responsible for fine particle production. The values of nozzle diameter, dispersion angle and sheet constant are tuned to get the particles with minimum diameter as output which is desirable for the drug particles to get deposited in the smaller airways of lungs and increase the efficiency of drug delivery and improve the device performance.

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Implementation and Test Run of Hospital-Pharmacy Cooperation Cloud System for Inhalation Therapy

2018 IEEE 7th Global Conference on Consumer Electronics (GCCE) ◽

10.1109/gcce.2018.8574665 ◽

2018 ◽

Author(s):

Taiki Irie ◽

Kazuya Yanashima ◽

Kenshiro Yoshimura ◽

Satoshi Yamauchi ◽

Sumika Fukuyama ◽

...

Keyword(s):

Hospital Pharmacy ◽

Cloud System ◽

Inhalation Therapy

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