Signet Ring Basal Cell CarcinomaA Case Study Emphasizing the Differential Diagnosis of Neoplasms with Signet Ring Cell Formation

2001 ◽  
Vol 197 (12) ◽  
pp. 853-856 ◽  
Author(s):  
K ARONI ◽  
A LAZARIS ◽  
I NIKOLAOU ◽  
A SAETTA ◽  
N KAVANTZAS ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell ◽  
Cell Formation ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Pathohistological and Immunohistochemical Analysis of Primary Invasive Ductal Breast Carcinoma with Signet-Ring Cell Differentiation- Differential Diagnosis, Prognosis and Complex Treatment

2020 ◽  
Vol 6 (3) ◽  
Keyword(s):  
Differential Diagnosis ◽  
Cell Differentiation ◽  
Hormone Therapy ◽  
Locally Advanced ◽  
Immunohistochemical Analysis ◽  
Signet Ring Cell ◽  
Tumor Control ◽  
Complex Treatment ◽  
Signet Ring ◽  
Ring Cell

Primary signet ring cell carcinoma (PSRCC) of the breast is a rarely diagnosed neoplasm. We present a 76-year-old woman with a tumor formation in the left mammary gland, who has been self-medicating for a year. Pathohistological and immunohistochemical analysis proved rare primary invasive ductal carcinoma with focal (over 90%) signet ring cell differentiation, size 4 cm / 3.5 cm / 2 cm, moderately differentiated (G2). Complex oncological treatment, including radical mastectomy with axillary dissection, 6 courses of systemic adjuvant chemotherapy, radiotherapy of the chest wall and regional lymph nodes with TD 46 Gy and antiestrogenic hormone therapy, was performed. The diagnosis and the differential diagnosis of this rare tumor require precise pathohistological and immunohistochemical analysis. The prognosis and complex treatment depend on the clinical stage, hormonal and HER2 status. In locally advanced PSRCC of the breast with moderately differentiation, the combination of surgery, systemic chemotherapy, postoperative radiotherapy and antiestrogenic hormone therapy achieves long-term local tumor control without distant metastases for nearly two years.

Signet Ring Cell Basal Cell Carcinoma

2001 ◽  
Vol 23 (6) ◽  
pp. 525-529 ◽  
Author(s):  
You Chan Kim ◽  
Daniel P. Vandersteen ◽  
Yoon Jae Chung ◽  
Na Hye Myong
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Signet-ring cell oligodendroglioma - report of two cases and discussion of the differential diagnosis

1997 ◽  
Vol 93 (6) ◽  
pp. 638-643 ◽  
Author(s):  
J. M. Kros ◽  
Willem A. van den Brink ◽  
Josine J. M. Loon-van Luyt ◽  
Stanislav Z. Stefanko
Keyword(s):  
Differential Diagnosis ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Signet-ring cell formation in cutaneous neoplasms☆, ☆☆, ★

1999 ◽  
Vol 41 (4) ◽  
pp. 606-613 ◽  
Author(s):  
B BASTIAN ◽  
H KUTZNER ◽  
T YEN ◽  
P LEBOIT
Keyword(s):  
Cell Formation ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary multifocal cystic signet ring neuroendocrine tumor of liver: a case report

2021 ◽  
Vol 21 (2) ◽  
pp. 187-193
Author(s):  
Nalini Bansal ◽  
Brahmananda Satapathy
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Neuroendocrine Tumor ◽  
Signet Ring Cell ◽  
Cystic Lesions ◽  
Rare Entity ◽  
Biliary Cystadenocarcinoma ◽  
Signet Ring ◽  
Ring Cell ◽  
Tumors Of The Liver

Primary signet ring neuroendocrine tumors of the liver are extremely rare tumors. Morphologically, they mimic signet ring cell adenocarcinomas; however, the absence of mucin by special stains and the expression of neuroendocrine markers help to diagnose these tumors. We herein report a case of a 47-year-old female who presented with multiple solid and cystic lesions in both liver lobes, which were initially suggested to be biliary cystadenocarcinoma on imaging. Liver biopsy of the lesion revealed the presence of a signet ring neoplasm with diffuse expression of synaptophysin and pan-cytokeratin. The case was subsequently diagnosed as a primary hepatic signet ring neuroendocrine tumor. The patient was offered 3 cycles of chemotherapy and is well preserved after 14 months of diagnosis. Although this is an extremely rare entity, its possibility should be considered in the differential diagnosis of neoplasms characterized by signet ring cell morphology.

Basal cell carcinoma with signet ring cell morphology accumulating the ubiquitinated cytokeratin 5/6

2021 ◽  
Vol 14 (4) ◽  
pp. e241993
Author(s):  
Ayako Watanabe ◽  
Naoshige Iida ◽  
Katsuhiko Enomoto
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cell Morphology ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Cytokeratin 5 ◽  
Ubiquitin Proteasome ◽  
Ring Cell ◽  
The Right

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Inside of the cancer islands, many tumour cells showed an enlarged fine granular cytoplasm with the peripherally compressed nuclei, being similar to the SR cell. Immunohistochemical examination revealed dense accumulation of cytokeratin (CK) 5/6 and a faint signal of 34βE12 in SR cells. The reported myoepithelial markers were not detected. Interestingly, ubiquitin, a component of the ubiquitin–proteasome protein degradation system, was co-localised in the SR cells. These suggest, for the first time, that accumulation of the undegraded CK5/6 with ubiquitination results in the SR cell morphology. Our report showed that the aberrant keratin turnover is associated with the SR cell BCC.

Signet-ring Cell Ependymoma: Case Report with Implications for Pathogenesis and Differential Diagnosis

1999 ◽  
Vol 195 (12) ◽  
pp. 853-858 ◽  
Author(s):  
István Vajtai ◽  
Zoltán Mucsi ◽  
Zsuzsanna Varga ◽  
István Bódi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell
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