Can dose–response models predict reliable normal tissue complication probabilities in radical radiotherapy of urinary bladder cancer? The impact of alternative radiation tolerance models and parameters

Background Urinary bladder carcinoma is common urological malignancy. Although epidemiological evidence favors role of occupational exposure to chemical carcinogen as the aetiological factor of bladder carcinoma, many cases arise with no obvious occupational exposure to chemical carcinogen. Tobacco and cigarette smoking is common in both rural and urban areas of Nepal.Objective The objective of this study was to determine the impact of smoking and age in urinary bladder carcinoma with related clinicopathological correlations.Method A total of 56 (44 males and 12 females) cases of urinary bladder cancer treated at Dhulikhel Hospital, Kathmandu University Teaching Hospital during time period of January 2004 to December 2013 were included in the study. Data of patients with Urinary bladder cancer were obtained from hospital records and evaluated for age, sex, history of smoking, clinical presentations, cystoscopic findings and histopathological characteristics.Results Out of 56 cases, 51 (91.1%) of the patients had hematuria. History of smoking was found in 44 patients. Smoking was found much higher in males (88%) than females (41.66%). Transitional cell carcinoma (TCC) was the most common histological variety, which was seen in 51 (91.07%) patients. The significant impact of smoking was found in terms of grade of TCC.Conclusion The incidence of bladder carcinoma is higher in male and TCC is the most common variety of Urinary bladder malignancy. History of smoking correlated with grade.Kathmandu Univ Med J 2013; 11(4): 292-295

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Radical radiotherapy for urinary bladder cancer: treatment outcomes

Expert Review of Anticancer Therapy ◽

10.1586/14737140.6.2.269 ◽

2006 ◽

Vol 6 (2) ◽

pp. 269-279 ◽

Cited By ~ 16

Author(s):

Lars Fokdal ◽

Morten Høyer ◽

Hans von der Maase

Keyword(s):

Bladder Cancer ◽

Urinary Bladder ◽

Cancer Treatment ◽

Treatment Outcomes ◽

Urinary Bladder Cancer ◽

Radical Radiotherapy

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Organ motion, set-up variation and treatment margins in radical radiotherapy of urinary bladder cancer

Radiotherapy and Oncology ◽

10.1016/s0167-8140(03)00246-9 ◽

2003 ◽

Vol 69 (3) ◽

pp. 291-304 ◽

Cited By ~ 133

Author(s):

Ludvig Paul Muren ◽

Rune Smaaland ◽

Olav Dahl

Keyword(s):

Bladder Cancer ◽

Urinary Bladder ◽

Urinary Bladder Cancer ◽

Organ Motion ◽

Radical Radiotherapy ◽

Treatment Margins ◽

Set Up

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Familial aggregation of bladder cancer

Vojnosanitetski pregled ◽

10.2298/vsp1105447i ◽

2011 ◽

Vol 68 (5) ◽

pp. 447-451 ◽

Cited By ~ 2

Author(s):

Milena Ilic ◽

Miroslav Stojadinovic ◽

Zoran Milosavljevic

Keyword(s):

Bladder Cancer ◽

Family History ◽

Urinary Bladder ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Familial Aggregation ◽

Transitional Cell ◽

Occupational Exposures ◽

Urinary Bladder Cancer ◽

The Impact

Background. Except for smoking and certain occupational exposures, the etiology of bladder cancer is largely unknown. Several case reports have described familial aggregation of transitional cell carcinoma of the bladder. Although the majority of patients with bladder cancer do not have family history of transitional cell carcinoma of the urinary tract, the study of familial transitional cell carcinoma may lead to the knowledge on the pathogenesis of this disease. The purpose of this study was to describe three cases of urinary bladder cancer in a single three-member family, i.e. in two generations (mother and son) and a family member related by marriage (the patient?s wife). Case report. Three cases of urinary bladder cancer occurred in a three-member family within the interval of 5 years. The following common characteristics were detected in our patients: old age (over 60), working as farmers for more than 50 years, negative personal medical history on relevant health disorders, place of birth - village, place of residence - village, the same water supply, similar nutrition, positive family history on urinary bladder cancer or other malignant tumors, the first sign of illness was macroscopic hematuria in all the patients and the same pathohistological type of cancer - carcinoma papillare transitiocellulare. Conclusion. The stated common characteristics in our cases indicate, above all, the impact of exposure to external surrounding factors on the occurrence of urinary bladder cancer.

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