Urinary Bladder Carcinoma: Impact of Smoking, Age and its Clinico-Pathological Spectrum

Background Urinary bladder carcinoma is common urological malignancy. Although epidemiological evidence favors role of occupational exposure to chemical carcinogen as the aetiological factor of bladder carcinoma, many cases arise with no obvious occupational exposure to chemical carcinogen. Tobacco and cigarette smoking is common in both rural and urban areas of Nepal.Objective The objective of this study was to determine the impact of smoking and age in urinary bladder carcinoma with related clinicopathological correlations.Method A total of 56 (44 males and 12 females) cases of urinary bladder cancer treated at Dhulikhel Hospital, Kathmandu University Teaching Hospital during time period of January 2004 to December 2013 were included in the study. Data of patients with Urinary bladder cancer were obtained from hospital records and evaluated for age, sex, history of smoking, clinical presentations, cystoscopic findings and histopathological characteristics.Results Out of 56 cases, 51 (91.1%) of the patients had hematuria. History of smoking was found in 44 patients. Smoking was found much higher in males (88%) than females (41.66%). Transitional cell carcinoma (TCC) was the most common histological variety, which was seen in 51 (91.07%) patients. The significant impact of smoking was found in terms of grade of TCC.Conclusion The incidence of bladder carcinoma is higher in male and TCC is the most common variety of Urinary bladder malignancy. History of smoking correlated with grade.Kathmandu Univ Med J 2013; 11(4): 292-295

Download Full-text

Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma

Journal of Clinical Medicine ◽

10.3390/jcm10163683 ◽

2021 ◽

Vol 10 (16) ◽

pp. 3683

Author(s):

Jacek Kudelski ◽

Grzegorz Młynarczyk ◽

Monika Gudowska-Sawczuk ◽

Barbara Mroczko ◽

Barbara Darewicz ◽

...

Keyword(s):

Bladder Cancer ◽

Matrix Metalloproteinases ◽

Urinary Bladder ◽

Matrix Metalloproteinase ◽

Bladder Carcinoma ◽

Urinary Bladder Cancer ◽

Urinary Bladder Carcinoma ◽

Low Grade ◽

High Grade ◽

Human Urinary Bladder

Human urinary bladder cancer is a huge worldwide oncological problem causing many deaths every year. The degradation of extracellular matrix (ECM) induced by molecules such as matrix metalloproteinases (MMPs) is one of the main factors influencing the process of metastasis origination. The MMP expression is tied to tumor aggressiveness, stage, and patient prognosis. The cleavage of constituent proteins is initiated and prolonged by matrix metalloproteinases, such as MMP-3 and MMP-10. The aim of this study was to evaluate the expression and activity of both MMPs in human urinary bladder cancer occurring at various stages of the disease. Tissue samples from patients with urinary bladder cancer were analyzed. Samples were collected from patients with a low- and high-grade cancer. Control tissue was collected from the site opposite to the tumor. DNA content, MMPs content, and activity of MMP-3 and MMP-10 were measured using ELISA and Western blot techniques. MMP-3 and MMP-10 occur in high molecular complexes in human urinary bladder in healthy and cancerous tissues. Particularly, in high-grade tumors, the content of MMP-10 prevails over MMP-3. The actual and specific activities vary in both grades of urinary bladder cancer; however, the highest activity for MMP-3 and MMP-10 was found in low-grade tissues. In conclusion, MMP-10 had a higher content, but a lower activity in all investigated tissues compared to MMP-3. Generally, obtained results demonstrated a contrary participation of MMP-3 and MMP-10 in ECM remodeling what may be crucial in the pathogenesis of human urinary bladder carcinoma.

Download Full-text

Association of arsenic with recurrence of urinary bladder cancer

Tropical Doctor ◽

10.1177/0049475520930155 ◽

2020 ◽

Vol 50 (4) ◽

pp. 325-330

Author(s):

Dilip K Pal ◽

Akash Agrawal ◽

Sabnam Ghosh ◽

Amlan Ghosh

Keyword(s):

Bladder Cancer ◽

Drinking Water ◽

Urinary Bladder ◽

West Bengal ◽

Urinary Bladder Cancer ◽

Tumour Tissue ◽

Aetiological Factor ◽

Arsenic Content ◽

Urinary Bladder Carcinoma ◽

Recurrent Bladder Cancer

Arsenic is known to be an important aetiological factor for the development of urinary bladder cancer. It is known to be found excessively in ground water in certain geographical areas, including West Bengal. We have studied patients with recurrent bladder cancer from different areas of this Indian state and correlated arsenic as a causative aetiological factor for development and aggressiveness of the biological behaviour of urinary cancer. We included 31 patients from various parts of West Bengal state with recurrent bladder cancer who were operated in our institute. Their clinical and residential data and their arsenic content of tumour tissue were measured. Statistical analysis was performed to test the association of tissue arsenic with clinicopathological features of recurrent disease. We found very high levels of arsenic in tumour tissue in all residents of the districts with high prevalence of arsenic in the drinking water. We also observed more aggressive clinicopathological progression and early recurrence in patients with high arsenic content. We conclude that arsenic is a causal factor in the clinicopathological progression of recurrent urinary bladder cancer. Measures to decrease the level of arsenic in drinking water should be taken as this may both improve clinicopathological outcomes in the recurrence of urinary bladder carcinoma, as well as reducing its overall incidence.

Download Full-text

Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure

Pharmacogenetics and Genomics ◽

10.1097/fpc.0b013e328331b554 ◽

2009 ◽

Vol 19 (11) ◽

pp. 903-906 ◽

Cited By ~ 39

Author(s):

Klaus Golka ◽

Matthias Hermes ◽

Silvia Selinski ◽

Meinolf Blaszkewicz ◽

Hermann M. Bolt ◽

...

Keyword(s):

Bladder Cancer ◽

Occupational Exposure ◽

Urinary Bladder ◽

Urinary Bladder Cancer

Download Full-text

Can dose–response models predict reliable normal tissue complication probabilities in radical radiotherapy of urinary bladder cancer? The impact of alternative radiation tolerance models and parameters

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(01)01464-x ◽

2001 ◽

Vol 50 (3) ◽

pp. 627-637 ◽

Cited By ~ 16

Author(s):

Ludvig Paul Muren ◽

Nina Jebsen ◽

Anders Gustafsson ◽

Olav Dahl

Keyword(s):

Bladder Cancer ◽

Urinary Bladder ◽

Dose Response ◽

Normal Tissue ◽

Urinary Bladder Cancer ◽

Radiation Tolerance ◽

Radical Radiotherapy ◽

Response Models ◽

The Impact

Download Full-text

Positron Emission Tomography in the Diagnosis and Staging of Urinary Bladder Cancer

Acta Radiologica ◽

10.1177/02841851960371p137 ◽

1996 ◽

Vol 37 (1P1) ◽

pp. 180-185 ◽

Cited By ~ 40

Author(s):

H. Ahlström ◽

P.-U. Malmström ◽

H. Letocha ◽

J. Andersson ◽

B. Långström ◽

...

Keyword(s):

Positron Emission Tomography ◽

Urinary Bladder ◽

Bladder Carcinoma ◽

Tnm Classification ◽

Primary Tumour ◽

Urinary Bladder Cancer ◽

Emission Tomography ◽

Urinary Bladder Carcinoma ◽

Positron Emission ◽

Before And After

Purpose: Evaluation of positron emission tomography (PET) using 18F-2-fluoro-2-deoxy-d-glucose (18FDG) and l-methyl-11C-methionine in the diagnosis and staging of urinary bladder carcinoma. Material and Methods: Twenty-three patients with biopsy-proven urinary bladder carcinoma were examined with PET after intravenous injection of 11C-methionine; 2 were also examined with 18FDG. The results from the PET investigations were compared with CT or MR findings and TNM classification before and after treatment. Results: The urinary excretion of 18FDG prevented distinction of the primary tumour from the surrounding tracer. With 11C-methionine it was possible to detect 18/23 primary tumours. A trend was seen, suggesting that the higher the uptake values of 11C-methionine in the tumour, the greater the tumour stage. Conclusion: It is possible to visualize urinary bladder tumours larger than 1 cm in diameter with PET using 11C-methionine, but the value of the method in the staging of the lesions is not superior to conventional methods.

Download Full-text

Familial aggregation of bladder cancer

Vojnosanitetski pregled ◽

10.2298/vsp1105447i ◽

2011 ◽

Vol 68 (5) ◽

pp. 447-451 ◽

Cited By ~ 2

Author(s):

Milena Ilic ◽

Miroslav Stojadinovic ◽

Zoran Milosavljevic

Keyword(s):

Bladder Cancer ◽

Family History ◽

Urinary Bladder ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Familial Aggregation ◽

Transitional Cell ◽

Occupational Exposures ◽

Urinary Bladder Cancer ◽

The Impact

Background. Except for smoking and certain occupational exposures, the etiology of bladder cancer is largely unknown. Several case reports have described familial aggregation of transitional cell carcinoma of the bladder. Although the majority of patients with bladder cancer do not have family history of transitional cell carcinoma of the urinary tract, the study of familial transitional cell carcinoma may lead to the knowledge on the pathogenesis of this disease. The purpose of this study was to describe three cases of urinary bladder cancer in a single three-member family, i.e. in two generations (mother and son) and a family member related by marriage (the patient?s wife). Case report. Three cases of urinary bladder cancer occurred in a three-member family within the interval of 5 years. The following common characteristics were detected in our patients: old age (over 60), working as farmers for more than 50 years, negative personal medical history on relevant health disorders, place of birth - village, place of residence - village, the same water supply, similar nutrition, positive family history on urinary bladder cancer or other malignant tumors, the first sign of illness was macroscopic hematuria in all the patients and the same pathohistological type of cancer - carcinoma papillare transitiocellulare. Conclusion. The stated common characteristics in our cases indicate, above all, the impact of exposure to external surrounding factors on the occurrence of urinary bladder cancer.

Download Full-text

Tuberculosis Complications After BCG Treatment for Urinary Bladder Cancer

Medicina ◽

10.3390/medicina48110082 ◽

2012 ◽

Vol 48 (11) ◽

pp. 82 ◽

Cited By ~ 3

Author(s):

Albinas Naudžiūnas ◽

Rūta Juškaitė ◽

Indrė Žiaugrytė ◽

Alvydas Unikauskas ◽

Eglė Varanauskienė ◽

...

Keyword(s):

Computed Tomography ◽

Bladder Cancer ◽

Surgical Treatment ◽

Urinary Bladder ◽

Urinary Bladder Cancer ◽

Pulmonary Diseases ◽

Bacillus Calmette Guerin ◽

History Of ◽

Muscle Invasive ◽

Bcg Instillation

Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis that has been effectively used in the treatment of non-muscle invasive bladder carcinoma. The complications of this treatment are uncommon, and the causes of dissemination are still discussed. We report a case of disseminated tuberculosis in a 66-year-old smoking man without a history of pulmonary diseases, who underwent immunotherapy with BCG after the initial surgical treatment of bladder cancer. After the last BCG instillation, he developed a fever. The diagnosis of sepsis was not confirmed, and miliary pulmonary tuberculosis was suspected. The diagnosis was confirmed by clinical manifestation, computed tomography of the lungs, and histological examination.

Download Full-text