Intestinal organoids as in vitro model system to assess safety and ADME properties of compounds

2021 ◽  
Vol 350 ◽  
pp. S119
Author(s):  
M. Derksen ◽  
S. Kourula ◽  
J.L. Roos ◽  
E. Frazer-Mendelewska ◽  
K.W. Lai ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Model System ◽  
Intestinal Organoids ◽  
Adme Properties ◽  
In Vitro Model System ◽  
Vitro Model

scholarly journals Exposure of ichnovirus particles to digitonin leads to enhanced infectivity and induces fusion from without in an in vitro model system

2007 ◽  
Vol 88 (11) ◽  
pp. 2977-2984 ◽  
Author(s):  
Don Stoltz ◽  
Renée Lapointe ◽  
Andrea Makkay ◽  
Michel Cusson
Keyword(s):  
Outer Membrane ◽  
In Vitro Model ◽  
Model System ◽  
Host Cells ◽  
Fusion Event ◽  
Susceptible Host ◽  
In Vitro Model System ◽  
Vitro Model

Unlike most viruses, the mature ichnovirus particle possesses two unit membrane envelopes. Following loss of the outer membrane in vivo, nucleocapsids are believed to gain entry into the cytosol via a membrane fusion event involving the inner membrane and the plasma membrane of susceptible host cells; accordingly, experimentally induced damage to the outer membrane might be expected to increase infectivity. Here, in an attempt to develop an in vitro model system for studying ichnovirus infection, we show that digitonin-induced disruption of the virion outer membrane not only increases infectivity, but also uncovers an activity not previously associated with any polydnavirus: fusion from without.

scholarly journals Development and validation of an in vitro model system to study peripheral sensory neuron development and injury

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Iwan Jones ◽  
Tushar Devanand Yelhekar ◽  
Rebecca Wiberg ◽  
Paul J. Kingham ◽  
Staffan Johansson ◽  
...  
Keyword(s):  
Sensory Neuron ◽  
In Vitro Model ◽  
Model System ◽  
Neuron Development ◽  
In Vitro Model System ◽  
Vitro Model ◽  
Development And Validation ◽  
Peripheral Sensory

scholarly journals THP-1 Macrophages and SGBS Adipocytes ? A New Human in vitro Model System of Inflamed Adipose Tissue

2011 ◽  
Vol 2 ◽  
Author(s):  
Michaela Keuper ◽  
Anna Dzyakanchuk ◽  
Kurt E. Amrein ◽  
Martin Wabitsch ◽  
Pamela Fischer-Posovszky
Keyword(s):  
Adipose Tissue ◽  
In Vitro Model ◽  
Model System ◽  
In Vitro Model System ◽  
Vitro Model

scholarly journals Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells

2016 ◽  
Vol 364 (3) ◽  
pp. 573-584 ◽  
Author(s):  
Patrick Wuchter ◽  
Rainer Saffrich ◽  
Stefan Giselbrecht ◽  
Cordula Nies ◽  
Hanna Lorig ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
In Vitro Model ◽  
Model System ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
In Vitro Model System ◽  
Vitro Model

scholarly journals Sa1517 – Larazotide Acetate Prevents and Rescues from Ethanolinduced Permeability Changes in an In Vitro Model System

2019 ◽  
Vol 156 (6) ◽  
pp. S-1231
Author(s):  
Jay Luther ◽  
Shadi Salloum ◽  
Jay Madan ◽  
Christopher p. Prior ◽  
Sandeep Laumas ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Model System ◽  
Permeability Changes ◽  
In Vitro Model System ◽  
Vitro Model

Profiling of Drugs for Membrane Activity Using Liposomes as an In Vitro Model System

2002 ◽  
Vol 28 (2) ◽  
pp. 193-202 ◽  
Author(s):  
Leo Grinius ◽  
David T. Stanton ◽  
Charles M. Morris ◽  
Jeremy M. Howard ◽  
Alan W. Curnow
Keyword(s):  
In Vitro Model ◽  
Model System ◽  
Membrane Activity ◽  
In Vitro Model System ◽  
Vitro Model
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