Analysis of cerebral perfusion and metabolism assessed with positron emission tomography before and after carotid artery stenting: Clinical article

2010 ◽  
Vol 2010 ◽  
pp. 214-215
Author(s):  
A.M. McKinney
Keyword(s):  
Positron Emission Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Cerebral Perfusion ◽  
Emission Tomography ◽  
Positron Emission ◽  
Before And After ◽  
Clinical Article

scholarly journals Intracerebral Hemorrhage after Carotid Artery Stenting without Evidence of Hyperperfusion in Positron Emission Tomography

2007 ◽  
Vol 13 (2) ◽  
pp. 191-199 ◽  
Author(s):  
A. Shindo ◽  
N. Kawai ◽  
K. Kawakita ◽  
M. Kawanishi ◽  
T. Tamiya ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Carotid Artery ◽  
Intracerebral Hemorrhage ◽  
Left Hemisphere ◽  
Carotid Artery Stenting ◽  
Right Hemisphere ◽  
Emission Tomography ◽  
Oxygen Extraction Fraction ◽  
Positron Emission ◽  
The Right

A 75-year-old man with a recent history of transient left hemiparesis and dysarthria was referred to our hospital. Angiography showed right internal carotid artery (ICA) occlusion and left ICA 89% stenosis. Positron emission tomography (PET) showed decreased cerebral blood flow (CBF), and increased oxygen extraction fraction (OEF) and cerebral blood volume (CBV) in the right hemisphere. In the left hemisphere, CBV was increased, but CBF and OEF remained normal. One month after the transient ischemic attack, left carotid artery stenting (CAS) was performed without complications. Diffusion-weighted magnetic resonance imaging (MRI) on the day after CAS showed no fresh ischemic lesion. PET on the second day after CAS showed increased CBF and decreased OEF and CBV in the right hemisphere as compared with those before CAS. In the left hemisphere, decreased CBV was observed and CBF was slightly increased as compared with those before CAS. The postoperative course was uneventful, but on the fifth day after CAS, the patient suddenly showed a focal seizure and right motor weakness. Emergency computed tomography scanning showed massive intracranial hemorrhage with severe brain edema in the left hemisphere. Although CBF study is useful to predict the hyperperfusion syndrome, we cannot disregard the possibility of intracerebral hemorrhage after CAS for carotid artery stenosis when there is no evidence of hyperperfusion on postoperative CBF study.

Positron Emission Tomography with 11C-Methionine and Computed Tomography of Intracranial Tumours Compared with Histopathologic Examination of Multiple Biopsies

1987 ◽  
Vol 28 (6) ◽  
pp. 673-681 ◽  
Author(s):  
M. Mosskin ◽  
H. von Holst ◽  
M. Bergström ◽  
V. P. Collins ◽  
L. Eriksson ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Contrast Medium ◽  
Mass Effect ◽  
Tumour Cells ◽  
Emission Tomography ◽  
Normal Brain ◽  
Positron Emission ◽  
Multiple Biopsies ◽  
Before And After

A selected group of 36 patients with suspected supratentorial gliomas were investigated with positron emission tomography (PET) using 11C-methionine and transmission computed tomography (CT) before and after intravenous injection of contrast medium. Every examination was performed with the head fixed in a plastic helmet and a baseplate to guarantee that the slice orientation was the same at examinations with the two modalities and over time. Guided by the examinations, multiple stereotactic biopsies were performed with the biopsy instrument mounted on the baseplate. Regional accumulation of methionine was compared with histology of the corresponding samples and with attenuation before and after injection of contrast medium as well as mass effect on CT. Typically, there was a low attenuating lesion with a slight mass effect on CT. There was an increased accumulation compared with normal brain tissue in 31 cases of tumours and ordinary or decreased accumulation in 3 cases of tumours. In 22 cases with increased accumulation of methionine the extension of the tumour judged by PET corresponded with that of histology. In 4 cases tumour cells were found outside the area with pathologic methionine uptake. In 5 patients there were areas with increased methionine accumulation where no tumour cells were found. In 22 cases PET using methionine was more accurate than CT in defining the tumour boundaries as determined from the histologic findings. Four groups of biopsy specimens with different amounts of methionine accumulation are described. The uptake in a single biopsy gives good but not exact information about the histology of the specimen.

scholarly journals Cerebral Blood Flow and Metabolism Measurement Using Positron Emission Tomography before and during Internal Carotid Artery Test Occlusions: Feasibility of Rapid Quantitative Measurement of CBF and OEF/CMRO2

2012 ◽  
Vol 18 (3) ◽  
pp. 264-274 ◽  
Author(s):  
N. Kawai ◽  
M. Kawanishi ◽  
A. Shindou ◽  
N. Kudomi ◽  
Y. Yamamoto ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
False Negative ◽  
Photon Emission ◽  
Emission Tomography ◽  
Positron Emission

Balloon test occlusion (BTO) of the internal carotid artery (ICA) combined with cerebral blood flow (CBF) study is a sensitive test for predicting the outcome of permanent ICA occlusion. However, false negative results sometimes occur using single photon emission tomography (SPECT). We have recently developed a rapid positron emission tomography (PET) protocol that measures not only the CBF but also the cerebral oxygen metabolism before and during BTO in succession. We measured acute changes in regional CBF and OEF/CMRO2 before and during BTO in three cases with large or giant cerebral aneurysms using the rapid PET protocol. Although no patients showed ischemic symptoms during BTO, PET studies exhibited mildly to moderately decreased CBF (9∼34%) compared to the values obtained before BTO in all cases. The average OEF during BTO was significantly increased (21% and 43%) than that of before BTO in two cases. The two cases were considered to be non-tolerant for permanent ICA occlusion and treated without ICA sacrifice. Measurement of the CBF and OEF/CMRO2 using a rapid PET protocol before and during BTO is feasible and can be used for accurate assessment of tolerance prediction in ICA occlusion.

Positron emission tomography in ischaemic stroke: cerebral perfusion and metabolism after stroke onset

1998 ◽  
Vol 5 (4) ◽  
pp. 413-416 ◽  
Author(s):  
Masahiro Yasaka ◽  
Stephen J Read ◽  
Graeme J O'Keefe ◽  
Gary F Egan ◽  
Owen Pointon ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Ischaemic Stroke ◽  
Cerebral Perfusion ◽  
Stroke Onset ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Measurement of Changes in Opioid Receptor Binding in Vivo During Trigeminal Neuralgic Pain Using [11C]Diprenorphine and Positron Emission Tomography

1999 ◽  
Vol 19 (7) ◽  
pp. 803-808 ◽  
Author(s):  
Anthony K. P. Jones ◽  
Niel D. Kitchen ◽  
Hiroshi Watabe ◽  
Vincent J. Cunningham ◽  
Terry Jones ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Volume Of Distribution ◽  
Emission Tomography ◽  
Subcortical Structures ◽  
Endogenous Opioid ◽  
Positron Emission ◽  
Before And After ◽  
Pain State ◽  
Parietal Cortices

The binding of [11C]diprenorphine to µ, κ, and Δ subsites in cortical and subcortical structures was measured by positron emission tomography in vivo in six patients before and after surgical relief of trigeminal neuralgia pain. The volume of distribution of [11C]diprenorphine binding was significantly increased after thermocoagulation of the relevant trigeminal division in the following areas: prefrontal, insular, perigenual, mid-cingulate and inferior parietal cortices, basal ganglia, and thalamus bilaterally. In addition to the pain relief associated with the surgical procedure, there also was an improvement in anxiety and depression scores. In the context of other studies, these changes in binding most likely resulted from the change in the pain state. The results suggest an increased occupancy by endogenous opioid peptides during trigeminal pain but cannot exclude coexistent down-regulation of binding sites.

Sign in / Sign up

Export Citation Format

Share Document