scholarly journals LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IS AN INDEPENDENT PREDICTOR OF LONG-TERM MORTALITY IN PATIENTS WHO UNDERWENT LIVER TRANSPLANT FOR END STAGE LIVER DISEASE

2014 ◽  
Vol 63 (12) ◽  
pp. A908
Author(s):  
Nandan Thirunahari ◽  
Adam Raskin ◽  
Ifad Ur Rahman ◽  
Rudzinski Wojciech ◽  
Christine Gerula ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Independent Predictor ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
End Stage Liver Disease ◽  
Ventricular Diastolic Dysfunction ◽  
End Stage ◽  
Long Term Mortality

P3466Cardiac output in end-stage liver disease increases with the severity of liver dysfunction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A N Koshy ◽  
B Cailes ◽  
P Gow ◽  
A Testro ◽  
J K Sajeev ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Liver Disease ◽  
Cardiac Function ◽  
Liver Transplant ◽  
Liver Dysfunction ◽  
Meld Score ◽  
Left Ventricular ◽  
Cirrhotic Cardiomyopathy ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Background End-stage liver disease is associated with significant systemic and haemodynamic alterations that affect cardiac function. Cirrhotic cardiomyopathy remains an ill-defined entity among cardiologists. Understanding the complex interplay between liver dysfunction and cardiac function can lead to a better understanding of the compensatory mechanisms of the heart in liver failure. Purpose To investigate whether severity of liver disease affects baseline cardiac output in a large contemporary cohort of patients undergoing liver transplant work-up. Methods Consecutive patients that underwent pre-liver transplant (LT) workup between 2010–2017 were included. All patients underwent a resting echocardiogram. Cardiac output (CO) was prospectively recorded at baseline by pulsed-wave Doppler examination of the left ventricular outflow tract from the apical window and systemic vascular resistance (SVR) was calculated as 80 x (mean arterial pressure (MAP)/CO). Severity of liver disease was characterized by the model of end-stage liver disease (MELD) and Child-Pugh scores. Results 560 patients were included (mean age 57.5±7.7, 74.8% male). Mean MELD score was 19±7 and Child-Pugh Score was 9±3. There was an inverse linear relationship between the severity of liver disease by the MELD score and baseline SVR (rho 0.40, P<0.001). As SVR reduced, there was also a significant rise in baseline CO with a strong inverse correlation between the two variables (rho 0.86, p<0.001). There was a significant linear correlation between the severity of liver disease and baseline CO with both the scores (MELD Score rho 0.42, p<0.001; Child Pugh rho 0.44, p<0.001) (Figure). Baseline CO in LT Patients by Severity Conclusions Baseline CO increased with the severity of liver dysfunction due to a reduced afterload. A higher resting CO may lead to patients encroaching on their cardiac reserve at rest. This provides a pathophysiological insight suggesting a limited role for beta-blockers, particularly in patients with advanced liver cirrhosis.

scholarly journals Non-alcoholic fatty liver disease and left ventricular diastolic dysfunction in patients with metabolic syndrome

2020 ◽  
Vol 183 (11) ◽  
pp. 25-33
Author(s):  
S. N. Jadhav ◽  
V. G. Radchenko
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Diastolic Dysfunction ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Alcoholic Fatty Liver ◽  
Ventricular Diastolic Dysfunction ◽  
Alcoholic Fatty Liver Disease

The purpose of the study was to determine the frequency and nature of manifestations of left ventricular diastolic dysfunction in patients with non-alcoholic fatty liver disease with the background of metabolic syndrome (MS).Characteristics of patients and research methods: To solve this problem, 227 patients with MS (130 men and 97 women) were examined. The study was conducted in two phases. At the first stage, all patients with MS are divided into two groups: patients with NAFLD — 205 people and 22 — without liver damage. At the next stage, a group of NAFLD patients with left ventricular DD (n=136) (66.34%) (the main group) and patients with no DD (n=69) (33.66%) (the comparison group) were identified.Results of the study: the results of diagnostics, clinical and laboratory manifestations of left ventricular diastolic dysfunction in 136 patients with NAFLD on the background of metabolic syndrome are Presented. Significant factors of development and progression of diastolic dysfunction were identified, which include increased body weight and adipose tissue, insulin resistance, dyslipidemia, hyperuricemia, activity and stage of liver damage. According to the data of structural and functional changes in the myocardium, the role of diastolic dysfunction in the development of chronic heart failure in patients with NAFLD with manifestations of metabolic syndrome has been established.Conclusion: it was Found that the development of left ventricular diastolic dysfunction in patients with NAFLD is due to the morphofunctional state of the liver.

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