THANKSGIVING MEAL PARALYSIS? A RARE CASE OF THYROTOXIC PERIODIC PARALYSIS WITH CARDIAC ARREST

Thyrotoxic periodic paralysis (TPP) is a rare etiology for muscle paralysis. It is frequently seen in Asian men. Apart from paralysis, most of them are asymptomatic and are devoid of other clinical features of hyperthyroidism. Due to the rarity of this condition, it is often missed and hence fatal. The metabolic derangement seen in TPP is hypokalemia and is thought to be the pathogenesis of the muscle paralysis. Although in rare clinical encounters, patients with TPP may present with normokalemia. The disorder usually presents in the 3rd decade. The cause for mortality in patients with TPP may be due to respiratory muscle paralysis leading to compromise of the respiratory function or refractory arrhythmias due to hypokalemia. Here we report a rare case of TPP with normokalemia.

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Abstract #1015: A Rare Case of Thyrotoxic Periodic Paralysis (TPP) Presenting in a Young African American Male Patient

Endocrine Practice ◽

10.1016/s1530-891x(20)44138-2 ◽

2017 ◽

Vol 23 ◽

pp. 218

Author(s):

Dania Assad ◽

Nashat Imran

Keyword(s):

African American ◽

Male Patient ◽

Rare Case ◽

African American Male ◽

Periodic Paralysis ◽

Thyrotoxic Periodic Paralysis

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A Rare Case of Thyrotoxic Periodic Paralysis Presenting to the Medical Examiner

American Journal of Forensic Medicine & Pathology ◽

10.1097/paf.0b013e318219ca5b ◽

2011 ◽

Vol 32 (3) ◽

pp. 232-235 ◽

Cited By ~ 1

Author(s):

Matthew P. Thompson ◽

J. Keith Pinckard

Keyword(s):

Rare Case ◽

Periodic Paralysis ◽

Medical Examiner ◽

Thyrotoxic Periodic Paralysis

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Thyrotoxic periodic paralysis due to excessive L-thyroxine replacement in a Caucasian man

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/acb.2009.009012 ◽

2009 ◽

Vol 46 (5) ◽

pp. 423-425 ◽

Cited By ~ 12

Author(s):

M J Hannon ◽

L A Behan ◽

A Agha

Keyword(s):

Cardiac Arrest ◽

Respiratory Muscle ◽

Periodic Paralysis ◽

Population Mobility ◽

Muscle Paralysis ◽

Fatal Complication ◽

The West ◽

Thyrotoxic Periodic Paralysis ◽

Thyroxine Replacement

Thyrotoxic periodic paralysis is a potentially fatal complication of hyperthyroidism, more common in Asian races, which is defined by a massive intracellular flux of potassium. This leads to profound hypokalaemia and muscle paralysis. Although the paralysis is temporary, it may be lethal if not diagnosed and treated rapidly, as profound hypokalaemia may induce respiratory muscle paralysis or cardiac arrest. The condition is often misdiagnosed in the west due to its comparative rarity in Caucasians; however it is now increasingly described in Caucasians and is also being seen with increasing frequency in western hospitals due to increasing immigration and population mobility. Here we describe the case of a patient with panhypopituitarism due to a craniopharyngioma, who developed thyrotoxic periodic paralysis due to excessive L-thyroxine replacement. This disorder has been described in Asian subjects but, to our knowledge, thyrotoxic periodic paralysis secondary to excessive L-thyroxine replacement has never been described in Caucasians.

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