PATIENTS ADMITTED FOR ACUTE DECOMPENSATED HEART FAILURE AND ELEVATED TROPONIN T HAVE IMPROVED 180-DAY MORTALITY AND MORBIDITY AFTER CORONARY ANGIOGRAPHY

Introduction: Heart failure is one of the leading cause of hospitalization and death worldwide having a major impact on the health care systems. Risk stratification of these patients helps to achieve a better clinical outcome with a reduction in morbidity and mortality. Methods: This was a single centre prospective observational study wherein patients with acute decompensated heart failure were enrolled. All enrolled patients underwent detailed clinical history including symptomatology, risk factors for cardiovascular diseases and family history were recorded. All these patients underwent routine haematological and biochemical testing along with documentation of cardiac biomarkers viz. Troponin T and N-terminal pro brain natriuretic peptide (NT pro-BNP). All these patients were then followed for one year. Outcomes in form of in-hospital mortality as well as adverse cardiac events (mortality, rehospitalisation) were documented. Results: A total of 264 patients were included with mean age of 67.6 ± 9.8 years. In-hospital mortality was reported in 28 patients (10.6%) while 27 (10.2%) patients died over a year of follow-up. Patients with an in-hospital mortality were older and higher NYHA class and heart rate, lower ejection fraction, systolic and diastolic blood pressure and higher cardiac troponins and NT-pro BNP levels. Multivariate logistic regression analysis revealed that heart rate, NYHA class, systolic blood pressures, NT pro-BNP and creatinine were independent predictors of mortality. Conclusions: Our study showed that acute heart failure has a substantial in-hospital as well as one year mortality rates. Use of biomarkers leads to a better risk stratification and hence an impact on outcomes.

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Association between troponin T and impaired left ventricular relaxation in patients with acute decompensated heart failure with preserved systolic function

European Journal of Echocardiography ◽

10.1093/ejechocard/jep063 ◽

2009 ◽

Vol 10 (6) ◽

pp. 765-768 ◽

Cited By ~ 21

Author(s):

R. V. Shah ◽

A. A. Chen-Tournoux ◽

M. H. Picard ◽

J. L. Januzzi

Keyword(s):

Heart Failure ◽

Troponin T ◽

Acute Decompensated Heart Failure ◽

Systolic Function ◽

Decompensated Heart Failure ◽

Left Ventricular ◽

Left Ventricular Relaxation ◽

Ventricular Relaxation

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High-Sensitivity Troponin T and Chance of Survival in Acute Decompensated Heart Failure

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2016.07.129 ◽

2016 ◽

Vol 22 (9) ◽

pp. S176

Author(s):

Keigo Hattori ◽

Makoto Suzuki ◽

Atsushi Seki ◽

Yuji Nagatomo ◽

Tetsuya Tobaru ◽

...

Keyword(s):

Heart Failure ◽

Troponin T ◽

Acute Decompensated Heart Failure ◽

High Sensitivity ◽

Decompensated Heart Failure ◽

High Sensitivity Troponin ◽

High Sensitivity Troponin T

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Biomarkers in Acute Decompensated Heart Failure

Clinical Medicine Insights Therapeutics ◽

10.4137/cmt.s18476 ◽

2015 ◽

Vol 7 ◽

pp. CMT.S18476

Author(s):

Andrew N. Rosenbaum ◽

Wayne L. Miller

Keyword(s):

Heart Failure ◽

Natriuretic Peptides ◽

Cardiac Troponin ◽

Troponin T ◽

Acute Decompensated Heart Failure ◽

Decompensated Heart Failure ◽

Cardiac Troponin T ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Galectin 3 ◽

Neutrophil Gelatinase

Acute decompensated heart failure (ADHF) is a prominent condition whose frequency is increasing, especially in the context of an aging population. The ability to discern the cause of undifferentiated dyspnea in acute presentations is an increasing struggle. In this review, we seek to explore the various biomarkers that have been studied for the diagnosis of ADHF and their respective clinical utilities as the most recent data would suggest. Natriuretic peptides, galectin-3, soluble ST2, adrenomedullin, cardiac troponin-T, neutrophil gelatinase-associated lipocalin, and copeptin are reviewed. Of these biomarkers, natriuretic peptides are the most thoroughly evaluated and show the most promise for diagnosis or exclusion of acute heart failure, though other biomarkers can add significant utility in the form of prognostication.

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