scholarly journals CLINICAL IMPLICATION OF LOW-DOSE ASPIRIN ON VASOSPASTIC ANGINA PATIENTS WITHOUT SIGNIFICANT CORONARY ARTERY STENOSIS

2016 ◽  
Vol 67 (13) ◽  
pp. 529
Author(s):  
A. Young Lim ◽  
Taek Kyu Park ◽  
Haseong Chang ◽  
Minsun Kim ◽  
Jeong Hoon Yang ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Clinical Implication ◽  
Low Dose ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Vasospastic Angina ◽  
Significant Coronary Artery Stenosis ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3341
Author(s):  
Hyun-Jin Kim ◽  
Min-Ho Lee ◽  
Sang-Ho Jo ◽  
Won-Woo Seo ◽  
Hack-Lyoung Kim ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Propensity Score ◽  
Clinical Outcomes ◽  
Coronary Artery Stenosis ◽  
Study Data ◽  
Artery Stenosis ◽  
Vasospastic Angina ◽  
Significant Stenosis ◽  
Significant Coronary Artery Stenosis ◽  
Increased Risk

Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the “significant stenosis” group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the “no significant stenosis” group (5.8% vs. 1.4%, respectively; p < 0.001). Additionally, the prevalence of ACS was significantly greater in the "significant stenosis" group (4.8% vs. 0.9%, respectively; p < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis.

Relationship between Whole Blood Viscosity and Lesion Severity in Coronary Artery Disease

2021 ◽  
Author(s):  
Gökhan Ceyhun ◽  
Oğuzhan Birdal
Keyword(s):  
Coronary Artery ◽  
Shear Rate ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Significant Stenosis ◽  
Whole Blood Viscosity ◽  
Significant Coronary Artery Stenosis ◽  
Coronary Syndrome

Abstract Objective This article investigates the relationship of fractional flow reserve (FFR) with whole blood viscosity (WBV) in patients who were diagnosed with chronic coronary syndrome and significant stenosis in the major coronary arteries and underwent the measurement of FFR. Material and Method In the FFR measurements performed to evaluate the severity of coronary artery stenosis, 160 patients were included in the study and divided into two groups as follows: 80 with significant stenosis and 80 with nonsignificant stenosis. WBVs at low shear rate (LSR) and high shear rate (HSR) were compared between the patients in the significant and nonsignificant coronary artery stenosis groups. Results In the group with FFR < 0.80 and significant coronary artery stenosis, WBV was significantly higher compared with the group with nonsignificant coronary artery stenosis in terms of both HSR (19.33 ± 0.84) and LSR (81.19 ± 14.20) (p < 0.001). In the multivariate logistic regression analysis, HSR and LSR were independent predictors of significant coronary artery stenosis (HSR: odds ratio: 1.67, 95% confidence interval: 1.17–2.64; LSR: odds ratio: 2.46, 95% confidence interval: 2.19–2.78). In the receiver operating characteristic (ROC) curve analysis, when the cutoff value of WBV at LSR was taken as 79.23, it had 58.42% sensitivity and 62.13% specificity for the prediction of significant coronary artery stenosis (area under the ROC curve: 0.628, p < 0.001). Conclusion WBV, an inexpensive biomarker that can be easily calculated prior to coronary angiography, was higher in patients with functionally severe coronary artery stenosis, and thus could be a useful marker in predicting the hemodynamic severity of coronary artery stenosis in patients with chronic coronary syndrome.

Abnormal myocardial perfusion pattern in the absence of significant coronary artery stenosis

2018 ◽  
Vol 25 (6) ◽  
pp. 2182-2185
Author(s):  
T. Sean Dunn ◽  
Jack Heo ◽  
Ami E. Iskandrian ◽  
Fadi G. Hage
Keyword(s):  
Coronary Artery ◽  
Myocardial Perfusion ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Significant Coronary Artery Stenosis

Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis

2020 ◽  
Vol 14 (16) ◽  
pp. 1553-1561
Author(s):  
Mehmet Erdoğan ◽  
Mehmet A Erdöl ◽  
Selçuk Öztürk ◽  
Tahir Durmaz
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Fractional Flow ◽  
Predictive Capacity ◽  
Significant Coronary Artery Stenosis ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Flow Reserve ◽  
Immune Inflammation

Aim: The study aimed to investigate and compare the predictive capacity of a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to determine a hemodynamically significant coronary artery stenosis assessed by fractional flow reserve (FFR). Patients & methods: A total of 207 chronic coronary syndrome patients with FFR measurement were enrolled in the study. NLR, PLR and SII levels were calculated. Results: The cut-off value of the SII (620) was associated with 78.4% sensitivity and 64.0% specificity to predict a hemodynamically significant stenosis. SII level independently predicted FFR ≤0.80. Conclusion: SII is an independent predictor of functionally significant coronary stenosis detected by FFR in chronic coronary syndrome patients. SII levels can predict hemodynamically severe obstruction better than NLR and PLR.

scholarly journals Prognostic Value of Gaiʼs Plaque Score and Agatston Coronary Artery Calcium Score for Functionally Significant Coronary Artery Stenosis

2016 ◽  
Vol 129 (23) ◽  
pp. 2792-2796 ◽  
Author(s):  
Chuang Zhang ◽  
Shuang Yang ◽  
Lu-Yue Gai ◽  
Zhi-Qi Han ◽  
Qian Xin ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Prognostic Value ◽  
Coronary Artery Stenosis ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Artery Stenosis ◽  
Plaque Score ◽  
Significant Coronary Artery Stenosis
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