VEPOLOXAMER (PURIFIED POLOXAMER-188) RESTORES INTEGRITY OF CARDIOMYOCYTE CALCIUM CYCLING PROTEINS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(16)31450-4 ◽

2016 ◽

Vol 67 (13) ◽

pp. 1449

Author(s):

Hani N. Sabbah ◽

Ramesh C. Gupta ◽

Vinita Sing-Gupta ◽

Kefei Zhang ◽

Marty Emanuele

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Calcium Cycling ◽

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Long-term therapy with Bendavia (MTP-131), a novel mitochondria-targeting peptide, reverses mitochondrial abnormalities in left ventricular myocardium of dogs with advanced heart failure

European Heart Journal ◽

10.1093/eurheartj/eht307.p640 ◽

2013 ◽

Vol 34 (suppl 1) ◽

pp. P640-P640

Author(s):

H. N. Sabbah ◽

R. C. Gupta ◽

S. Rastogi ◽

M. Wang ◽

K. Zhang

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Term Therapy ◽

Left Ventricular Myocardium ◽

Targeting Peptide ◽

Long Term Therapy ◽

Mitochondria Targeting

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Thymosin β4 and Its Cleavage Product Ac-SDKP Are Down-Regulated in Left Ventricular Myocardium of Patients With Advanced Heart Failure

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2015.01.238 ◽

2015 ◽

Vol 34 (4) ◽

pp. S89 ◽

Author(s):

H.N. Sabbah ◽

R.C. Gupta ◽

V. Singh-Gupta

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Cleavage Product ◽

Left Ventricular Myocardium ◽

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BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, IMPROVES ACTIVITY AND EXPRESSION OF CYTOCHROME-C OXIDASE AND ATTENUATES MEDIATORS OF CARDIOMYOCYTE APOPTOSIS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(13)60710-x ◽

2013 ◽

Vol 61 (10) ◽

pp. E710 ◽

Author(s):

Hani N. Sabbah ◽

Ramesh C. Gupta ◽

Kristina Szekely ◽

Mengjun Wang ◽

Kefei Zhang ◽

...

Keyword(s):

Heart Failure ◽

Cytochrome C ◽

Cytochrome C Oxidase ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Cardiomyocyte Apoptosis ◽

Left Ventricular Myocardium ◽

Targeting Peptide ◽

Mitochondria Targeting

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P6170Elamipretide normalizes protein and mRNA expression levels of mitofilin in left ventricular myocardium of dogs with advanced heart failure

European Heart Journal ◽

10.1093/eurheartj/ehx493.p6170 ◽

2017 ◽

Vol 38 (suppl_1) ◽

Author(s):

H.N. Sabbah ◽

R.C. Gupta ◽

V. Singh-Gupta ◽

K. Zhang ◽

J. Xu

Keyword(s):

Heart Failure ◽

Mrna Expression ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Expression Levels ◽

Mrna Expression Levels

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BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, NORMALIZES EXPRESSION OF CARDIOLIPIN REMODELING GENES AND PROTEINS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)60758-0 ◽

2014 ◽

Vol 63 (12) ◽

pp. A758 ◽

Author(s):

Hani N. Sabbah ◽

Ramesh C. Gupta ◽

Sharad Rastogi ◽

Mengjun Wang ◽

Kefei Zhang ◽

...

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Targeting Peptide ◽

Mitochondria Targeting

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Abstract 538: Reduced Protein and mRNA Levels of Velosin Containing Protein in Left Ventricular Myocardium of Dogs With Advanced Heart Failure Are Restored Following Chronic Therapy With Elamipretide

Circulation Research ◽

10.1161/res.123.suppl_1.538 ◽

2018 ◽

Vol 123 (Suppl_1) ◽

Author(s):

Ramesh C Gupta ◽

Vinita S Gupta ◽

Hani Sabbah

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Mrna Levels ◽

Chronic Therapy

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Elamipretide Normalizes Protein and mRNA Expression Levels of Mitofilin in Left Ventricular Myocardium of Dogs with Advanced Heart Failure

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2018.01.539 ◽

2018 ◽

Vol 37 (4) ◽

pp. S219

Author(s):

H.N. Sabbah ◽

R.C. Gupta

Keyword(s):

Heart Failure ◽

Mrna Expression ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Expression Levels ◽

Mrna Expression Levels

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BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, IMPROVES ACTIVITIES OF MITOCHONDRIA COMPLEX-I AND COMPLEX-IV IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)60882-2 ◽

2014 ◽

Vol 63 (12) ◽

pp. A882

Author(s):

Hani N. Sabbah ◽

Ramesh C. Gupta ◽

Sharad Rastogi ◽

Mengjun Wang ◽

Kefei Zhang ◽

...

Keyword(s):

Heart Failure ◽

Complex I ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium ◽

Targeting Peptide ◽

Mitochondria Targeting ◽

Mitochondria Complex I

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HEART RATE REDUCTION WITH IVABRADINE IMPROVES SARCOPLASMIC RETICULUM CALCIUM CYCLING IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH MODERATE HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(11)60323-9 ◽

2011 ◽

Vol 57 (14) ◽

pp. E323 ◽

Author(s):

Ramesh C. Gupta ◽

Mengjun Wang ◽

Itamar Ilsar ◽

Michael S. Sabbah ◽

Kaitlin Dye ◽

...

Keyword(s):

Heart Failure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Left Ventricular Myocardium ◽

Heart Rate Reduction ◽

Calcium Cycling ◽

Rate Reduction ◽

Moderate Heart Failure ◽

Sarcoplasmic Reticulum Calcium

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DYSFUNCTIONAL IRON HOMEOSTASIS IN MITOCHONDRIA FROM LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(15)61011-7 ◽

2015 ◽

Vol 65 (10) ◽

pp. A1011

Author(s):

Vinita Singh-Gupta ◽

Ramesh Gupta ◽

Hani N. Sabbah

Keyword(s):

Heart Failure ◽

Iron Homeostasis ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Advanced Heart Failure ◽

Left Ventricular Myocardium

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