scholarly journals THE ANTI-PLATELET EFFECT OF DIFFERENT LOADING DOSE OF TICAGRELOR IN PATIENTS WITH NON-ST ACUTE CORONARY SYNDROME UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: A RANDOMIZED, OPEN-LABEL, MULTICENTER STUDY

2016 ◽  
Vol 67 (13) ◽  
pp. 1497
Author(s):  
Liu Huiliang ◽  
Yu-Jie Wei ◽  
Zhi-Geng Jin ◽  
Peng Ding ◽  
Sheng-Li Yang ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Multicenter Study ◽  
Coronary Intervention ◽  
Loading Dose ◽  
Open Label ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

scholarly journals Clopidogrel or ticagrelor alongside dabigatran in acute coronary syndrome and indication for NOAC: a study rationale

2021 ◽  
Author(s):  
Jasper Luijkx ◽  
Patty Winkler ◽  
Arnoud van 't Hof
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Controlled Trial ◽  
Oral Anticoagulants ◽  
Academic Research ◽  
Coronary Intervention ◽  
Open Label ◽  
P2y12 Inhibitors ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

The combination of oral anticoagulants with platelet inhibitors has been widely investigated in patients with coronary stenting and concomitant atrial fibrillation. In these patients, default therapy after percutaneous coronary intervention in acute coronary syndrome is clopidogrel plus non–vitamin K antagonist oral anticoagulant, omitting aspirin. However, in view of the high thromboembolic risk associated with acute coronary syndrome and the number of poor metabolizers for clopidogrel, investigation of alternative P2Y12-inhibitors is mandatory. This prospective, multicenter, open-label, registry-based, randomized, controlled trial aims to show the non-inferiority of dabigatran plus ticagrelor versus dabigatran plus clopidogrel in patients on chronic anticoagulants who undergo percutaneous coronary intervention in acute coronary syndrome. The primary end point is major bleeding as defined by the Bleeding Academic Research Consortium bleeding definition. Trial registration number: NL75644.096.21

scholarly journals Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome

JAMA ◽  
2018 ◽  
Vol 319 (13) ◽  
pp. 1331 ◽  
Author(s):  
Otavio Berwanger ◽  
Eliana Vieira Santucci ◽  
Pedro Gabriel Melo de Barros e Silva ◽  
Isabella de Andrade Jesuíno ◽  
Lucas Petri Damiani ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Cardiovascular Events ◽  
Coronary Intervention ◽  
Major Adverse Cardiovascular Events ◽  
Loading Dose ◽  
Coronary Syndrome ◽  
Percutaneous Coronary
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