CIRCULATING SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR LEVELS PREDICT MORTALITY IN SUBJECTS WITHOUT OBSTRUCTIVE CORONARY ARTERY DISEASE

2018 ◽  
Vol 71 (11) ◽  
pp. A1870
Author(s):  
Nabil Sabbak ◽  
Ahmed AlBadri ◽  
Ayman Samman Tahhan ◽  
Pratik Sandesara ◽  
Ayman Alkhoder ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasminogen Activator ◽  
Obstructive Coronary Artery Disease ◽  
Urokinase Plasminogen Activator ◽  
Urokinase Plasminogen Activator Receptor ◽  
Plasminogen Activator Receptor ◽  
Artery Disease

P6436Soluble urokinase plasminogen activator receptor and functionally relevant coronary artery disease: a prospective cohort study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J E Walter ◽  
M Amrein ◽  
L Koechlin ◽  
J Du Fay De Lavallaz ◽  
T Zimmermann ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasminogen Activator ◽  
Cardiovascular Death ◽  
Urokinase Plasminogen Activator Receptor ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Plasminogen Activator Receptor ◽  
Artery Disease ◽  
Multivariable Adjustment

Abstract Background The urokinase system is pivotal in the pathogenesis of atherosclerosis. Therefore, soluble urokinase plasminogen activator receptor (suPAR) concentrations may help in the detection of functionally relevant coronary artery disease (fCAD). Purpose To evaluate suPAR as diagnostic marker for fCAD. Methods Among consecutive patients with symptoms suggestive of fCAD, fCAD was adjudicated blinded to suPAR concentrations in two domains: first, diagnosis of fCAD according to myocardial perfusion single photon emission tomography (MPI-SPECT) and coronary angiography; second, fCAD according to cardiovascular death, non-fatal acute myocardial infarction (AMI) and all-cause death during 2-year follow-up. Results Among 968 patients, symptoms were adjudicated to be causally related to fCAD in 26% (255/968). SuPAR concentrations were higher in patients with fCAD as compared to those without (3.45 ng/mL versus 3.20 ng/mL, p=0.007), but overall had only low diagnostic accuracy (area under the curve [AUC]: 0.56, 95% CI 0.52–0.60) and were not independent predictors of fCAD after multivariable adjustment. Circulating suPAR concentrations were modestly correlated with high-sensitivity cardiac troponin (hs-cTn) T (Spearman's rho 0.393, p<0.001), NT-proBNP (Spearman's rho 0.327, p<0.001) and age (Spearman's rho 0.364, p<0.001), but only weakly correlated with the extent of coronary atherosclerosis as quantified by perfusion defects (Spearman's rho 0.123, p<0.001). Prognostically, suPAR concentrations had moderate-to-high accuracy in the prediction of cardiovascular death (AUC 0.72, 95% CI 0.62–0.81) and all-cause death (AUC 0.72, 95% CI 0.65–0.79) at 2-years, and remained a significant predictor for all-cause death after multivariable adjustment (p=0.001). SuPAR concentrations did not predict non-fatal AMI. Conclusions SuPAR is an independent predictor of death, but not helpful in the detection of fCAD. Acknowledgement/Funding European Union, Swiss National Science Foundation, the Swiss Heart Foundation, the Cardiovascular Research Foundation Basel, the University of Basel,

scholarly journals Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yuli Huang ◽  
Haobin Zhou ◽  
Yu Wu ◽  
You Yang ◽  
Wensheng Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
High Sensitivity ◽  
Chinese Patients ◽  
C Reactive Protein ◽  
Urokinase Plasminogen Activator Receptor ◽  
Reactive Protein ◽  
Plasminogen Activator Receptor ◽  
Artery Disease

Background. Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians. This study investigated the role of suPAR in young Chinese patients with CAD.Methods. The study involved a total of 196 consecutive young (age ≤ 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls. Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays.Results. Levels of suPAR were significantly correlated with age (r=0.20,P=0.04), smoking (r=0.33,P=0.008), body mass index (r=0.21,P=0.03), and high-sensitivity C-reactive protein (hs-CRP;r=0.31,P=0.01). Multivariate logistic regression analysis showed that male sex (odds ratio (OR) = 3.12; 95% confidence interval (CI) = 1.18–8.25,P=0.02), smoking (OR = 3.41, 95% CI = 1.55–7.50,P=0.002), triglyceride (OR = 1.89, 95% CI = 1.10–3.25,P=0.02), high-sensitivity C-reactive protein (OR = 1.24, 95% CI = 1.02–0.03,P=0.03), and suPAR (OR = 1.37, 95% CI = 1.09–1.72,P=0.007) were independently associated with CAD risk in young patients.Conclusions. SuPAR is a novel independent risk factor for CAD in young Chinese patients. Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed.

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