scholarly journals Attenuated metabolic and increased renal effects of angiotensin II (ang II) in early type 2 diabetes mellitus (NIDDM)

1997 ◽  
Vol 10 (4) ◽  
pp. 15A
Author(s):  
D FLISER
Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1168-P ◽  
Author(s):  
SHRITA M. PATEL ◽  
MARY A. HICKMAN ◽  
ROBERT FREDERICH ◽  
BRETT LAURING ◽  
STEVEN TERRA ◽  
...  

1997 ◽  
Vol 15 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Danilo Fliser ◽  
Christine Keller ◽  
Philipp Bahrmann ◽  
Edward Franek ◽  
Hans Schreckling ◽  
...  

2006 ◽  
Vol 34 (3) ◽  
pp. 297-302 ◽  
Author(s):  
F Yu ◽  
T Takahashi ◽  
J Moriya ◽  
K Kawaura ◽  
J Yamakawa ◽  
...  

We examined the effects of the angiotensin-II receptor antagonist candesartan on non-alcoholic fatty liver (NAFL) and circulating adiponectin concentrations in KKAy obese mice with type 2 diabetes mellitus. The KKAy mice were randomly assigned to receive either candesartan at a once-daily dose of 10 mg/kg ( n = 5) or placebo ( n = 5). The differences in liver weight, histological evaluation of hepatic lipid infiltration, serum adiponectin concentration and hepatic adiponectin mRNA levels between the two groups were determined on day 7 after treatment was initiated. Candesartan-treated mice demonstrated significantly lower liver weights and reduced lipid droplets in hepatic cells compared with control mice. The circulating adiponectin levels and hepatic expression of adiponectin mRNA were significantly higher in candesartan-treated mice than control mice. These results suggest that candesartan might alleviate NAFL through elevation of circulating adiponectin levels in KKAy obese mice with type 2 diabetes mellitus.


2015 ◽  
Vol 31 (12) ◽  
pp. 2219-2231 ◽  
Author(s):  
Vlado Perkovic ◽  
Meg Jardine ◽  
Ujjwala Vijapurkar ◽  
Gary Meininger

2019 ◽  
Vol 97 (S263) ◽  
Author(s):  
María José Vicente ◽  
Elisa Vilades ◽  
Elvira Orduna ◽  
Beatriz Cordón ◽  
Javier Pérez‐Velilla ◽  
...  

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