EVALUATION OF PRODROMAL SYMPTOMS IN FIRST-EPISODE PSYCHOSIS

Objective: As part of the DSM-IV field trial for psychotic disorders, the authors endeavoured to determine the reliability of the DSM-IV prodromal features for schizophrenia in a first-episode sample. Method: Fifty first-episode psychotic patients were assessed using a semi-structured instrument to determine the presence/absence of nine prodromal symptoms. Inter-rater reliability data were calculated for 25 of the patients, and test-retest data were calculated for the remaining 25 patients. Results: Levels of reliability were poor. Conclusions: The results lend some support to American Psychiatric Association and World Health Organization decisions to omit specific criteria for prodromal features from their respective nosologies.

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Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

Neuropsychopharmacology ◽

10.1038/npp.2011.65 ◽

2011 ◽

Vol 36 (9) ◽

pp. 1781-1791 ◽

Cited By ~ 156

Author(s):

Camilo de la Fuente-Sandoval ◽

Pablo León-Ortiz ◽

Rafael Favila ◽

Sylvana Stephano ◽

David Mamo ◽

...

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Prodromal Symptoms ◽

Episode Psychosis

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Prevalence of the metabolic syndrome in patients at risk of psychosis

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.058 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S92-S92

Author(s):

J. Cordes ◽

A. Bechdolf ◽

S. Moebus

Keyword(s):

Metabolic Syndrome ◽

Genetic Factors ◽

Fasting Blood Glucose ◽

First Episode Psychosis ◽

First Episode ◽

Clinical High Risk ◽

Prodromal Symptoms ◽

The Metabolic Syndrome ◽

Episode Psychosis ◽

Patients At Risk

The metabolic syndrome (MetS) is one of the most frequent reasons for the higher mortality in patients with schizophrenia. It is difficult to separate between effects of medication or the disorder itself on the development of MetS. In the present study, patients at clinical high risk for first-episode psychosis (CHR) were examined and the prevalence of the MetS was assessed. One hundred and sixty-three unmedicated antipsychotic naïve CHR patients aged between 18 and 42 years and suffering from unmanifested prodromal symptoms were compared to 35,869 patients of the “German Metabolic and Cardiovascular Risk Study” (GEMCAS). We observed a slightly higher prevalence of single MetS criteria in CHR group compared to the GEMCAS sample, in particular: high blood pressure (35.0 vs. 28.0%), waist circumference (17.6 vs. 15.1%), and high fasting blood glucose (9.4 vs. 4.0%). We assume the higher risk for MetS in schizophrenia patients or CHR patients to derive from genetic factors.Disclosure of interestIn cooperation with Joachim Cordes, Andreas Bechdolf, Christina Engelke, Kahl KG, Chakrapani Balijepalli, Christian Lösch, Joachim Klosterkötter, Michael Wagner, Wolfgang Maier, Andreas Heinz, Walter de Millas, Wolfgang Gaebel, Frank Schneider, Martin Lambert, Georg Juckel, Thomas Wobrock, Michael Riedel, Susanne Moebus.

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First-Episode Psychosis in the Military: A Comparative Study of Prodromal Symptoms

Australian & New Zealand Journal of Psychiatry ◽

10.1046/j.1440-1614.2001.00912.x ◽

2001 ◽

Vol 35 (4) ◽

pp. 512-519 ◽

Cited By ~ 42

Author(s):

Hao-Yang Tan ◽

Yong-Guan Ang ◽

Hao-Yang Tan ◽

Yong-Guan Ang

Keyword(s):

Sleep Disturbance ◽

Depressed Mood ◽

Psychotic Disorders ◽

Social Withdrawal ◽

Young Patients ◽

First Episode Psychosis ◽

Psychotic Symptoms ◽

First Episode ◽

Prodromal Symptoms ◽

Episode Psychosis

Objective: The objective of this study is to provide a retrospective description of prodromal symptoms of young military servicemen with first-episode psychosis, and a comparison with first-episode non-psychotic disorders. Method: Thirty consecutive servicemen presenting with first-episode psychosis were studied. Thirty-four randomly selected servicemen from 123 with non-psychotic disorders served as comparison. A combination of unstructured and semistructured interviews with the patient and other informants was used to describe the prodromal symptoms. Results: The most common prodromal psychotic symptoms were social withdrawal (83%); anxiety (77%); sleep disturbance (77%); disturbance in attention, concentration or memory (73%); deterioration in studies in school (70%); depressed mood (63%); odd behaviour (53%); and anger or irritability (53%). Common symptoms found in first-episode psychosis and non-psychotic patients included sleep disturbance, anxiety, depressed mood and anger or irritability. Common symptoms that were associated with the psychotic prodrome were social withdrawal (p < 0.001), deterioration in school results (p < 0.001) and disturbance in attention, concentration or memory (p < 0.001). The psychotic prodrome was also associated with apathy (p < 0.001), odd behaviour (p < 0.001), doing nothing (p = 0.004) and thought blocking (p = 0.04). Conclusion: Cognitive disturbances and attenuated negative symptoms appear to be more specific to the psychotic prodrome in young patients with first-episode psychosis.

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