Deficient Th1-type immune responses via impaired CD28 signaling in ultraviolet B-induced systemic immunosuppression and the restorative effect of IL-12

2000 ◽  
Vol 24 (3) ◽  
pp. 190-202 ◽  
Author(s):  
Osamu Ando ◽  
Yasuo Suemoto ◽  
Masashi Kurimoto ◽  
Tatsuya Horikawa ◽  
Masamitsu Ichihashi
Keyword(s):  
Immune Responses ◽  
Ultraviolet B ◽  
Systemic Immunosuppression

Effects of Ultraviolet B Light on Cutaneous Immune Responses of Humans with Deeply Pigmented Skin

1991 ◽  
Vol 97 (4) ◽  
pp. 729-734 ◽  
Author(s):  
Martin Vermeer ◽  
George J Schmieder ◽  
Takeshi Yoshikawa ◽  
Jan-Willem van den Berg ◽  
Michael S Metzman ◽  
...  
Keyword(s):  
Immune Responses ◽  
Ultraviolet B

Immunity to jellyfish venoms: Suppression of venom-induced immune responses in ultraviolet B-irradiated mice

Toxicon ◽  
1993 ◽  
Vol 31 (11) ◽  
pp. 1415-1422 ◽  
Author(s):  
Shunsuke Miura ◽  
Joseph W. Burnett ◽  
Laure Aurelian
Keyword(s):  
Immune Responses ◽  
Ultraviolet B

scholarly journals Dermal Mast Cells Determine Susceptibility to Ultraviolet B–induced Systemic Suppression of Contact Hypersensitivity Responses in Mice

1998 ◽  
Vol 187 (12) ◽  
pp. 2045-2053 ◽  
Author(s):  
Prue H. Hart ◽  
Michele A. Grimbaldeston ◽  
Georgina J. Swift ◽  
Aleksandra Jaksic ◽  
Frances P. Noonan ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Ultraviolet B ◽  
Contact Hypersensitivity ◽  
Delayed Type Hypersensitivity ◽  
Parental Origin ◽  
Uvb Radiation ◽  
Uvb Irradiation ◽  
Systemic Immunosuppression ◽  
Different Strains

Different strains of mice have varying susceptibilities to ultraviolet radiation (UV) of wavelength 280–320 nm (UVB) for 50% suppression of systemic contact hypersensitivity (CHS) responses. Prevalence of histamine-staining dermal mast cells in different strains of mice (C57BL/ 6J, DBA/2, BALB/c) correlated directly with their susceptibility to UVB-induced systemic immunosuppression. BALB/c mice carrying Uvs1, a major locus for susceptibility to UV-induced immunosuppression, contained greater numbers of dermal mast cells than BALB/c mice of the same parental origin. Strains of mice that were differentiated on their susceptibility to UVB-induced downregulation of systemic CHS responses were similar in their susceptibility to histamine-induced immunomodulation. Histamine, but not UVB irradiation, decreased systemic CHS responses in mast cell–depleted mice (W  f/W  f). Reconstitution of the dorsal skin of W  f/W  f mice with bone marrow–derived mast cell precursors from nonmutant mice rendered the mice susceptible to UVB irradiation for systemic suppression of CHS responses. UVB irradiation did not suppress delayed type hypersensitivity responses to allogeneic spleen cells in W  f/W  f mice. In contrast, UV irradiation suppressed CHS responses in W  f/W  f mice when hapten was applied to the irradiated site. This study demonstrates that dermal mast cells are necessary for the induction of systemic suppression of CHS responses by UVB radiation, and suggests that mast cell– derived histamine is one component of this UVB-induced systemic immunosuppression.

scholarly journals Influence of Ultraviolet B Exposure on Immune Responses Following Hepatitis B Vaccination in Human Volunteers

2001 ◽  
Vol 117 (5) ◽  
pp. 1144-1150 ◽  
Author(s):  
Annemarie Sleijffers ◽  
Johan Garssen ◽  
Frank R. de Gruijl ◽  
Greet J. Boland ◽  
Jan van Hattum ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Ultraviolet B ◽  
Hepatitis B Vaccination ◽  
Human Volunteers
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