scholarly journals the Effect of Quetiapine on Auditory p300 Response in Patients with Schizoaffective Disorder: Preliminary Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Korostenskaja ◽  
K. Dapsys ◽  
A. Siurkute ◽  
A. Dudlauskaite ◽  
A. Pragaraviciene ◽  
...  
Keyword(s):  
Information Processing ◽  
Schizoaffective Disorder ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
P300 Latency ◽  
Auditory Information ◽  
Auditory Oddball ◽  
Auditory P300 ◽  
Active Attention ◽  
Auditory Information Processing

Abnormalities in attention, memory and information processing are considered to be the primary deficits in schizophrenia. Event-related potential (ERP) P300 could reflect deficits in auditory information processing related to active attention in schizophrenia patients. Atypical antipsychotics tend to ameliorate cognitive deficits, however their effects on neural aspects of cognitive dysfunction have not been consistent.Aim:To investigate the effects of quetiapine on auditory information processing by using auditory P300.Methods:We examined 7 patients with schizoaffective disorder, depressive type and 7 age- and sex-matched healthy controls. ERPs were elicited during active auditory “oddball” paradigm. P300 was recorded before and after two weeks of treatment with quetiapine (468.7±143 mg/day).Results:Baseline P300 latencies were significantly delayed in patients compared with controls. Quetiapine did not change P300 amplitudes. However, it normalized P300 latency. These results suggest that already after two weeks of treatment, quetiapine could have a beneficial effect on the active attention reflected in P300 in patients with schizoaffective disorder. Previous studies with antipsychotic drugs such as olanzapine and risperidone failed to show changes in P300 after this treatment interval.Conclusion:Quetiapine may be faster than other neuroleptics in ameliorating attentional dysfunction in patients with schizoaffective disorder. However, studies with a larger sample size must be conducted in order to confirm or reject the results of the current study.

Auditory information processing (oddball paradigm): An impact of COMT polymorphism

2008 ◽  
Author(s):  
I. S. Lebedeva ◽  
G. I. Korovaitseva ◽  
T. V. Lezheiko ◽  
V. G. Kaleda ◽  
L. I. Abramova ◽  
...  
Keyword(s):  
Information Processing ◽  
Oddball Paradigm ◽  
Auditory Information ◽  
Auditory Information Processing ◽  
Comt Polymorphism

scholarly journals Relationship between early and late stages of information processing: an event-related potential study

2012 ◽  
Vol 4 (3) ◽  
pp. 16 ◽  
Author(s):  
Claudio Portella ◽  
Sergio Machado ◽  
Oscar Arias-Carrión ◽  
Alexander T. Sack ◽  
Julio Guilherme Silva ◽  
...  
Keyword(s):  
Information Processing ◽  
Visual Input ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
P300 Latency ◽  
Secondary Processing ◽  
Late Event ◽  
Visual Oddball Paradigm ◽  
Late Stages ◽  
The Brain

The brain is capable of elaborating and executing different stages of information processing. However, exactly how these stages are processed in the brain remains largely unknown. This study aimed to analyze the possible correlation between early and late stages of information processing by assessing the latency to, and amplitude of, early and late event-related potential (ERP) components, including P200, N200, premotor potential (PMP) and P300, in healthy participants in the context of a visual oddball paradigm. We found a moderate positive correlation among the latency of P200 (electrode O2), N200 (electrode O2), PMP (electrode C3), P300 (electrode PZ) and the reaction time (RT). In addition, moderate negative correlation between the amplitude of P200 and the latencies of N200 (electrode O2), PMP (electrode C3), P300 (electrode PZ) was found. Therefore, we propose that if the secondary processing of visual input (P200 latency) occurs faster, the following will also happen sooner: discrimination and classification process of this input (N200 latency), motor response processing (PMP latency), reorganization of attention and working memory update (P300 latency), and RT. N200, PMP, and P300 latencies are also anticipated when higher activation level of occipital areas involved in the secondary processing of visual input rise (P200 amplitude).

Auditory Information Processing in Schizophrenia

1997 ◽  
Vol 35 (4) ◽  
pp. 191-196 ◽  
Author(s):  
B. Van Sweden ◽  
M.G. Van Erp ◽  
F. Mesotten
Keyword(s):  
Information Processing ◽  
Auditory Information ◽  
Auditory Information Processing

scholarly journals Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaohong Liu ◽  
Hongliang Zhou ◽  
Chenguang Jiang ◽  
Yanling Xue ◽  
Zhenhe Zhou ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Alcohol Dependence ◽  
Control Function ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Group Level ◽  
Auditory Oddball ◽  
State Dependent ◽  
Simple Effect ◽  
Time Point

Alcohol dependence (AD) presents cognitive control deficits. Event-related potential (ERP) P300 reflects cognitive control-related processing. The aim of this study was to investigate whether cognitive control deficits are a trait biomarker or a state biomarker in AD. Participants included 30 AD patients and 30 healthy controls (HCs). All participants were measured with P300 evoked by a three-stimulus auditory oddball paradigm at a normal state (time 1, i.e., just after the last alcohol intake) and abstinence (time 2, i.e., just after a 4-week abstinence). The results showed that for P3a and P3b amplitude, the interaction effect for group × time point was significant, the simple effect for group at time 1 level and time 2 level was significant, and the simple effect for time point at AD group level was significant; however, the simple effect for time point at HC group level was not significant. Above results indicated that compared to HCs, AD patients present reductions of P3a/3b amplitude, and after 4-week alcohol abstinence, although P3a/3b amplitudes were improved, they were still lower than those of HCs. For P3a and P3b latencies, no significant differences were observed. These findings conclude that AD patients present cognitive control deficits that are reflected by P3a/3b and that cognitive control deficits in AD are trait- and state-dependent. The implication of these findings is helpful to understand the psychological and neural processes for AD, and these findings suggest that improving the cognitive control function may impact the treatment effect for AD.

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