1342 – Deficits and biases of facial emotion recognition in ultra-high risk for psychosis and first-episode schizophrenia

Abstract Background Schizophrenia patients and individuals at ultra-high risk for psychosis(UHR) have shown impaired facial emotion recognition(FER). Previous studies have reported lower accuracy and negative bias of FER in schizophrenia and UHR. These impairments have been studied with various factors such as schizotypy and paranoid level, but the results were inconsistent. This study aimed to identify the impairments of FER in UHR individuals and further to examine how these impairments relate to schizotypy and paranoid level. Methods orty-three UHR individuals and 57 normal controls (NC) were requested to perform the facial emotion recognition(FER) task that consist of 60 facial photographs selected from standardized photographs of Ekman and Friesen series. For exploratory correlation analysis, schizotypy (Revised physical anhedonia scale, Magical ideation scale) and paranoid level (Paranoia scale, Persecution/suspicious item of Positive and Negative Syndrome Scale) were also examined in UHR individuals. Results The UHR individuals showed lower accuracy rate for total FER task (70.6% vs. 75.6%, p=0.010) and more “fear” responses for neutral faces (14.5% vs. 6.0%, p=0.003) than NC. In exploratory correlation analysis for UHR individuals, the total accuracy rate of FER task showed significant correlation with both scales for schizotypy, but not with both scales for paranoid level. Among threat-related emotion response rates for neutral face, only “Disgust” response rate for neutral face was correlated with all scales for paranoid level, but not with scales for schizotypys in UHR individuals. Discussion In this study, we could identify inaccuracy and negative bias of FER in UHR individuals, Furthermore, we found that inaccuracy and negative bias were associated with schizotypy and paranoid level, respectively. These findings imply that inaccuracy and negative bias of FER in UHR individuals are of different nature. Future studies on the clinical implications of these findings would be needed.

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P.545 Facial emotion recognition in first-episode psychosis: correlations with functionality and quality of life

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2020.09.397 ◽

2020 ◽

Vol 40 ◽

pp. S306-S307

Author(s):

J. Vouk-Kamenski ◽

D. Bosnjak Kuharic ◽

M. Rojnic Kuzman

Keyword(s):

Quality Of Life ◽

Emotion Recognition ◽

First Episode Psychosis ◽

Facial Emotion Recognition ◽

Facial Emotion ◽

First Episode ◽

Episode Psychosis

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White matter microstructure in ultra-high risk and first episode schizophrenia: A prospective study

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2015.11.003 ◽

2016 ◽

Vol 247 ◽

pp. 42-48 ◽

Cited By ~ 14

Author(s):

Silvia Rigucci ◽

Giulia Santi ◽

Valentina Corigliano ◽

Annamaria Imola ◽

Camilla Rossi-Espagnet ◽

...

Keyword(s):

White Matter ◽

High Risk ◽

Prospective Study ◽

First Episode ◽

White Matter Microstructure ◽

Ultra High Risk ◽

A Prospective Study ◽

First Episode Schizophrenia

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S150. EMOTIONAL BEHAVIOUR IN HIGH-RISK AND FIRST-EPISODE PSYCHOSIS

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa031.216 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S93-S93

Author(s):

Irina Falkenberg ◽

Huai-Hsuan Tseng ◽

Gemma Modinos ◽

Barbara Wild ◽

Philip McGuire ◽

...

Keyword(s):

High Risk ◽

Emotion Recognition ◽

Psychotic Disorders ◽

First Episode Psychosis ◽

First Episode ◽

Healthy Controls ◽

Emotional Faces ◽

Facial Movements ◽

Episode Psychosis ◽

Ultra High Risk

Abstract Background Studies indicate that people with schizophrenia and first-episode psychosis experience deficits in their ability to accurately detect and display emotions through facial expressions, and that functioning and symptoms are associated with these deficits. This study aims to examine how emotion recognition and facial emotion expression are related to functioning and symptoms in a sample of individuals at ultra-high risk, first-episode psychosis and healthy controls. Methods During fMRI, we combined the presentation of emotional faces with the instruction to react with facial movements predetermined and assigned. 18 patients with first-episode psychosis (FEP), 18 individuals at ultra high risk of psychosis (UHR) and 22 healthy controls (HCs) were examined while viewing happy, sad, or neutral faces and were instructed to simultaneously move the corners of their mouths either (a). upwards or (b). downwards, or (c). to refrain from movement. The subjects’ facial movements were recorded with an MR-compatible video camera. Results Neurofunctional and behavioral response to emotional faces were measured. Analyses have only recently commenced and are ongoing. Full results of the clinical and functional impact of behavioral and neuroimaging results will be presented at the meeting. Discussion Increased knowledge about abnormalities in emotion recognition and behaviour as well as their neural correlates and their impact on clinical measures and functional outcome can inform the development of novel treatment approaches to improve social skills early in the course of schizophrenia and psychotic disorders.

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