Effect of iron and/or vitamin A re-supplementation on vitamin A and iron status of rats after a dietary deficiency of both components

2002 ◽  
Vol 16 (3) ◽  
pp. 175-178 ◽  
Author(s):  
Michael A. Ameny ◽  
Jens Raila ◽  
Erwin Walzel ◽  
Florian J. Schweigert
Keyword(s):  
Vitamin A ◽  
Iron Status ◽  
Dietary Deficiency

scholarly journals Prenatal Zinc and Vitamin A Reduce the Benefit of Iron on Maternal Hematologic and Micronutrient Status at Delivery in Tanzania

2019 ◽  
Vol 150 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Ramadhani A Noor ◽  
Ajibola I Abioye ◽  
Anne Marie Darling ◽  
Ellen Hertzmark ◽  
Said Aboud ◽  
...  
Keyword(s):  
Vitamin A ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Iron Status ◽  
Zinc Protoporphyrin ◽  
Plasma Zinc ◽  
Vitamin A Supplementation ◽  
Iron Supplements ◽  
Micronutrient Status ◽  
Increased Risk

ABSTRACT Background Zinc and vitamin A supplementation have both been shown to affect iron status, hemoglobin (Hb) concentration, and anemia in animal and human studies. However, evidence on their combined use in pregnancy, in the context of iron–folic acid (IFA) supplementation, remains limited. Objective This study determined the effects of prenatal zinc, vitamin A, and iron supplementation on maternal hematologic and micronutrient status at delivery in Tanzania. Methods We analyzed 2 large randomized controlled trials, using generalized estimating equations, and examined the effect of daily zinc (25 mg) and vitamin A (2500 IU) supplementation starting in the first trimester of pregnancy compared with placebo (n = 2500), and separately evaluated the safety and efficacy of daily iron (60 mg) supplementation among iron-replete pregnant women (n = 1500). Blood samples from baseline and delivery were tested for Hb, serum ferritin, soluble transferrin receptor, plasma zinc, and zinc protoporphyrin. Results Zinc and vitamin A supplementation were associated with lower Hb concentrations at delivery of  −0.26 g/dL (95% CI: −0.50, −0.02 g/dL) and −0.25 g/dL (95% CI: −0.49, −0.01 g/dL), respectively. Vitamin A increased mean ferritin concentrations at delivery (14.3 μg/L, 95% CI: 1.84, 29.11 μg/L), but was associated with increased risk of severe anemia (RR: 1.41; 95% CI: 1.06, 1.88). Among women who were iron replete at baseline, iron supplementation reduced the risk of iron depletion at delivery by 47% (RR: 0.53; 95% CI: 0.43, 0.65). There was no effect of zinc or iron supplements on plasma zinc concentrations. Conclusions Our findings support existing WHO guidelines on prenatal iron, vitamin A, and zinc supplementation among pregnant women. In this setting, scaling uptake of prenatal iron supplements is warranted, but prenatal zinc and vitamin A supplementation did not benefit maternal hematologic status at delivery. In settings where vitamin A deficiency is endemic, the efficacy and safety of the WHO recommended prenatal vitamin A supplementation require further evaluation.

scholarly journals Maize meal fortification is associated with improved vitamin A and iron status in adolescents and reduced childhood anaemia in a food aid-dependent refugee population

2008 ◽  
Vol 11 (7) ◽  
pp. 720-728 ◽  
Author(s):  
Andrew Seal ◽  
Emmanuel Kafwembe ◽  
Ismail AR Kassim ◽  
Mei Hong ◽  
Annie Wesley ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Iron Status ◽  
Household Survey ◽  
Refugee Camp ◽  
Food Aid ◽  
Serum Retinol ◽  
Post Intervention ◽  
Vitamin A Status ◽  
Maize Meal

AbstractObjectiveTo assess changes in the Fe and vitamin A status of the population of Nangweshi refugee camp associated with the introduction of maize meal fortification.DesignPre- and post-intervention study using a longitudinal cohort.SettingNangweshi refugee camp, Zambia.SubjectsTwo hundred and twelve adolescents (10–19 years), 157 children (6–59 months) and 118 women (20–49 years) were selected at random by household survey in July 2003 and followed up after 12 months.ResultsMaize grain was milled and fortified in two custom-designed mills installed at a central location in the camp and a daily ration of 400 g per person was distributed twice monthly to households as part of the routine food aid ration. During the intervention period mean Hb increased in children (0·87 g/dl;P< 0·001) and adolescents (0·24 g/dl;P= 0·043) but did not increase in women. Anaemia decreased in children by 23·4 % (P< 0·001) but there was no significant change in adolescents or women. Serum transferrin receptor (log10-transformed) decreased by −0·082 μg/ml (P= 0·036) indicating an improvement in the Fe status of adolescents but there was no significant decrease in the prevalence of deficiency (−8·5 %;P= 0·079). In adolescents, serum retinol increased by 0·16 μmol/l (P< 0·001) and vitamin A deficiency decreased by 26·1 % (P< 0·001).ConclusionsThe introduction of fortified maize meal led to a decrease in anaemia in children and a decrease in vitamin A deficiency in adolescents. Centralised, camp-level milling and fortification of maize meal is a feasible and pertinent intervention in food aid operations.

scholarly journals The Influence of Vitamin A Supplementation on Iron Status

Nutrients ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 4399-4413 ◽  
Author(s):  
Fernanda Michelazzo ◽  
Julicristie Oliveira ◽  
Juliana Stefanello ◽  
Liania Luzia ◽  
Patricia Rondó
Keyword(s):  
Vitamin A ◽  
Iron Status ◽  
Vitamin A Supplementation

scholarly journals Vitamin A and iron status and intake of fortifiable foods among Cameroonian women and preschool children

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Kenneth H Brown ◽  
Reina Engle‐Stone ◽  
Alex Ongla Ndjebayi ◽  
Juergen Erhardt ◽  
Martin Nankap
Keyword(s):  
Preschool Children ◽  
Vitamin A ◽  
Iron Status

Canthaxanthin and Excess Vitamin A Alter α-Tocopherol, Carotenoid and Iron Status in Adult Rats

1991 ◽  
Vol 121 (10) ◽  
pp. 1649-1655 ◽  
Author(s):  
Shirley R. Blakely ◽  
Geraldine V. Mitchell ◽  
Mamie Y. Jenkins ◽  
Erich Grundel ◽  
Paul Whittaker
Keyword(s):  
Vitamin A ◽  
Iron Status ◽  
Adult Rats

ULTRAVIOLET LIGHT-ENHANCED VISUALIZATION OF CUTANEOUS SIGNS OF CAROTENE AND VITAMIN A DIETARY DEFICIENCY

2004 ◽  
Vol 59 (2) ◽  
pp. 97-101 ◽  
Author(s):  
E. Uhoda ◽  
L. Petit ◽  
C. Piérard-Franchimont ◽  
G.E. Piérard
Keyword(s):  
Vitamin A ◽  
Ultraviolet Light ◽  
Dietary Deficiency

scholarly journals Can Increased Vegetable Consumption Improve Iron Status?

1996 ◽  
Vol 17 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Saskia de Pee ◽  
Clive E. West ◽  
Muhilal ◽  
Darwin Karyadi ◽  
Joseph G. A. J. Hautvast
Keyword(s):  
Vitamin A ◽  
Intervention Studies ◽  
Vegetable Consumption ◽  
Iron Status ◽  
Provitamin A ◽  
Review Of The Literature ◽  
Fortified Foods ◽  
Plant Foods ◽  
Provitamin A Carotenoids ◽  
Vitamin A Status

Theoretically, vegetable consumption could improve iron status. First, vegetables contain iron. Second, when the provitamin A carotenoids in vegetables improve vitamin A status, the result could be increased iron levels. Most studies on vegetable consumption have focused on improvements in vitamin A status, and only very few have addressed iron status. From a review of the literature and a recent study in Indonesia, we conclude that the data on the effectiveness of vegetables to improve the levels of both nutrients are inconclusive. The bioavailability of both iron and provitamin A carotenoids might be lower than expected. It is necessary to conduct other intervention studies using plant foods, animal foods, and fortified foods. In the meantime, other strategies that have been proved to reduce iron and vitamin A deficiencies should continue.

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