scholarly journals Prenatal Zinc and Vitamin A Reduce the Benefit of Iron on Maternal Hematologic and Micronutrient Status at Delivery in Tanzania

2019 ◽  
Vol 150 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Ramadhani A Noor ◽  
Ajibola I Abioye ◽  
Anne Marie Darling ◽  
Ellen Hertzmark ◽  
Said Aboud ◽  
...  
Keyword(s):  
Vitamin A ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Iron Status ◽  
Zinc Protoporphyrin ◽  
Plasma Zinc ◽  
Vitamin A Supplementation ◽  
Iron Supplements ◽  
Micronutrient Status ◽  
Increased Risk

ABSTRACT Background Zinc and vitamin A supplementation have both been shown to affect iron status, hemoglobin (Hb) concentration, and anemia in animal and human studies. However, evidence on their combined use in pregnancy, in the context of iron–folic acid (IFA) supplementation, remains limited. Objective This study determined the effects of prenatal zinc, vitamin A, and iron supplementation on maternal hematologic and micronutrient status at delivery in Tanzania. Methods We analyzed 2 large randomized controlled trials, using generalized estimating equations, and examined the effect of daily zinc (25 mg) and vitamin A (2500 IU) supplementation starting in the first trimester of pregnancy compared with placebo (n = 2500), and separately evaluated the safety and efficacy of daily iron (60 mg) supplementation among iron-replete pregnant women (n = 1500). Blood samples from baseline and delivery were tested for Hb, serum ferritin, soluble transferrin receptor, plasma zinc, and zinc protoporphyrin. Results Zinc and vitamin A supplementation were associated with lower Hb concentrations at delivery of  −0.26 g/dL (95% CI: −0.50, −0.02 g/dL) and −0.25 g/dL (95% CI: −0.49, −0.01 g/dL), respectively. Vitamin A increased mean ferritin concentrations at delivery (14.3 μg/L, 95% CI: 1.84, 29.11 μg/L), but was associated with increased risk of severe anemia (RR: 1.41; 95% CI: 1.06, 1.88). Among women who were iron replete at baseline, iron supplementation reduced the risk of iron depletion at delivery by 47% (RR: 0.53; 95% CI: 0.43, 0.65). There was no effect of zinc or iron supplements on plasma zinc concentrations. Conclusions Our findings support existing WHO guidelines on prenatal iron, vitamin A, and zinc supplementation among pregnant women. In this setting, scaling uptake of prenatal iron supplements is warranted, but prenatal zinc and vitamin A supplementation did not benefit maternal hematologic status at delivery. In settings where vitamin A deficiency is endemic, the efficacy and safety of the WHO recommended prenatal vitamin A supplementation require further evaluation.

scholarly journals Community Pharmacist-Led Interventions to Improve Preconception and Pregnancy Health: A Systematic Review

Pharmacy ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 171
Author(s):  
Polly A. Scott ◽  
Ola F. Quotah ◽  
Kathryn V. Dalrymple ◽  
Sara L. White ◽  
Lucilla Poston ◽  
...  
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Health Outcomes ◽  
Pregnant Women ◽  
Community Pharmacist ◽  
Iron Status ◽  
Preliminary Evidence ◽  
Iron Supplements ◽  
Micronutrient Status ◽  
Improve Health

Background: Community pharmacist-led interventions are effective in improving health outcomes; however, their impact in improving preconception and pregnancy health is not clear. This study evaluated the effectiveness of community pharmacist-led interventions which aimed to improve health outcomes of preconception and pregnant women. Methods: A systematic review of the literature, consistent with PRISMA guidelines, was performed. Five electronic databases were searched up to February 2021. Results: Four studies, three in pregnant women and one in preconception women, were identified. The studies focused on improving micronutrient status and smoking cessation. The studies increased knowledge about, and use of, iron supplements, and improved iron status and smoking cessation rates in pregnant women, while improving knowledge regarding, and increasing the use of, preconception folic acid. The studies were ranked as weak to moderate quality. Conclusion: This review provides preliminary evidence for the potential benefit of community pharmacist-led interventions to improve the health of women before and during pregnancy.

scholarly journals Effect of iron supplementation on the iron status of pregnant women: consequences for newborns

1997 ◽  
Vol 66 (5) ◽  
pp. 1178-1182 ◽  
Author(s):  
P Preziosi ◽  
A Prual ◽  
P Galan ◽  
H Daouda ◽  
H Boureima ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Iron Supplementation ◽  
Iron Status

scholarly journals Hubungan Pengetahuan Dan Kepatuhan Ibu Hamil Konsumsi Tablet Tambah Darah Dengan Kejadian Anemia Di Kecamatan Leitimur Selatan Dan Teluk Ambon

2021 ◽  
pp. 229-236
Author(s):  
Elpira Asmin ◽  
Armando Salulinggi ◽  
Christiana Rialine Titaley ◽  
Johan Bension
Keyword(s):  
Pregnant Women ◽  
Iron Supplementation ◽  
Analytical Study ◽  
Cross Sectional ◽  
Iron Supplements ◽  
Nutritional Problem ◽  
Women's Knowledge ◽  
The Relationship ◽  
Women’S Knowledge ◽  
Prevalence Of Anemia

Background: Anemia is a public health nutritional problem, especially for pregnant women. Anemia in pregnancy can adversely affect the morbidity and mortality of both mother and baby. According to the WHO, the prevalence of anemia in Indonesia was 40.5% in 2015, and 42% in 2016. One of the government's efforts to reduce the rate of anemia is the provision of iron tablets. In Indonesia, the coverage of giving at least 90 tablets during pregnancy in 2017 reached 80.81%. However, in Maluku Province, the coverage of iron supplementation (47.35%) was included amongst the four lowest provinces. This study aims to examine the relationship between pregnant women's knowledge and consumption of iron tablets and anemia in the Districts of South Leitimur and Teluk Ambon. Methods: This research is an analytical study with a cross-sectional approach. The subjects of this study were 165 pregnant women who were taken by purposive sampling.Result: The results showed 50.3% of pregnant women had anemia and only 21.8% complied with taking iron tablets. We found that there was no statistically significant association between pregnant women's knowledge of iron supplementation (p=0.443), as well as compliance with taking iron supplements (p=0.135), and anemia. Nevertheless, the percentage of women with anemia was lower in pregnant women who complied with taking iron supplements than those who did not comply. Conclusion : This study shows that efforts are still required to reduce the prevalence of anemia in Ambon City, including increasing women's compliance to take iron tablets.

scholarly journals Vitamin A and Nutritional Anaemia

1996 ◽  
Vol 17 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Djoko Suharno ◽  
Muhilal
Keyword(s):  
Placebo Group ◽  
Iron Deficiency ◽  
Vitamin A ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Ferrous Sulphate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin A Status

A cross-sectional study of the prevalence of iron and vitamin A deficiencies in 318 pregnant women revealed that 50.7% had iron deficiency and 21.3% had marginally deficient or deficient vitamin A status. Based on results, the influence of vitamin A and iron supplementation was studied in 305 anaemic pregnant women in west Java, in a randomized, doubleblind, placebo-controlled field trial. The women with a haemoglobin between 80 and 109 g/L were randomly allocated to four groups: vitamin A (2.4 mg retinol) and placebo iron tablets; iron (60 mg elemental iron as ferrous sulphate) and placebo vitamin A; vitamin A and iron; and both placebos, all daily for eight weeks. Maximum haemoglobin was achieved with both vitamin A and iron supplementation (12. 78 g/L, 95% Cl 10.86 to 14.70), with one-third of the response attributable to vitamin A (3.68 g/L, 2.03 to 5.33) and two-thirds to iron (771 g/L, 5.97 to 9.45). After supplementation, the proportion of women who became non-anaemic was 35 % in the vitamin Asupplemented group, 68% in the ironsupplemented group, 97% in the group supplemented with both, and 16% in the placebo group. We conclude that improvement in vitamin A status may contribute to the control of anaemia in pregnant women.

scholarly journals Assessment of Gastrointestinal Symptoms and Non-transferrin Bound Iron After Oral Ferrous Sulfate and Iron-enriched Aspergillus Oryzae Supplementation in Women (P24-039-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Amanda Bries ◽  
Chong Wang ◽  
Brian Wels ◽  
Isaac Agbemafle ◽  
Olivia Meier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Iron Supplementation ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Supplements

Abstract Objectives Iron deficiency anemia (IDA) is a widespread nutritional deficiency. Iron supplementation with ferrous sulfate (FeSO4) is the most common strategy to treat IDA; however, the compliance with daily FeSO4 administration is poor, due to contraindicating side effects. Previously, we have reported that A. oryzae (Ultimine®; ULT) is a novel iron source. Therefore, the objective of this study was to determine the biochemical assessment, non-transferrin bound iron (NTBI) and commonly related gastrointestinal side effects to assess the safety of A. oryzae compared to FeSO4. Methods Female participants (n = 16) with serum ferritin concentrations 40 µg/L were randomized to a double-blind, 9-wk cross-over study with a 3-wk placebo washout period between treatments. Oral iron supplements (65 mg Fe), FeSO4 and ULT were administered for 21 consecutive days for each subject. Side effect questionnaires were collected 3d/wk over the 9-wk study period. Side effects and biochemical markers (nausea, heartburn, abdominal pain, fatigue, headache, diarrhea, constipation, oxidative stress and liver and kidney function) from iron supplementation were evaluated, along with serum iron, % transferrin saturation (TS) and NBTI 8 h curves. Results Serum iron, TS, and NTBI were all markedly higher with FeSO4 at each time-point from 2–8 hours (P < 0.001) compared to ULT, whereas NTBI was undetected. Among treatments, FeSO4 resulted in higher inflammation, though not statistically significant. Compliance based on returned pills was higher with ULT (97.3%) than placebo and FeSO4 (95.2% and 93.2%, respectively). Subjects taking FeSO4 reported abdominal discomfort 2% more than ULT, which was not significantly different. FeSO4 caused marginally higher incidence of combined nauseation, constipation and diarrhea when subjects were taking FeSO4 (P < 0.07). Iron status was maintained similarly by both oral iron supplements. Oxidative stress, inflammation, kidney and liver function markers were not elevated with ULT supplementation, suggesting safety of its consumption. Conclusions Better compliance and less gastrointestinal related side effects were reported with ULT compared to FeSO4, while maintaining normal iron status. Our data suggests ULT is a safe oral iron supplement for treatment of IDA. Funding Sources Cura Global Health, Inc.

scholarly journals Prenatal multivitamin supplementation increases birth weight

2017 ◽  
Vol 6 (6) ◽  
pp. 2148
Author(s):  
Müberra Namli Kalem ◽  
Zeynep Kamalak ◽  
Nermin Kosus ◽  
Aydin Kosus ◽  
Ziya Kalem
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Positive Impact ◽  
Maternal Diet ◽  
Vitamin Supplementation ◽  
Control Group ◽  
Iron Group ◽  
Multivitamin Supplementation ◽  
Iron Supplements

Background: The aim of this study is to examine whether there is any positive impact of prenatal iron and vitamin supplementation on birth weight, and if this practice could be a cause of macrosomia.Methods: A total of 1,838 term pregnant women were included in this study and were divided into four groups: iron group (women having only iron supplementation), vitamin (women using only multivitamins), vitamin+iron (women using both iron and multivitamin preparations), and control group (women having neither iron nor vitamin supplements). Statistical analysis was performed to compare age, gravida, parity, hemoglobin, BMI and birth weight. Groups were compared in terms of macrosomia and correlation analysis carried out between demographics and birth weight.Results: The birth weight was significantly higher in the vitamin group and the vitamin+iron group than in the iron group and the control group. Vitamin supplementation increased the risk of macrosomia 3.9 times, while vitamin+iron usage increased the risk 4.8 times.Conclusions: Uncontrolled use of multivitamins and/or iron supplements may increase tendency for fetal macrosomia. The use of multivitamins and/or iron supplements by pregnant women must take into account maternal age, maternal diet and maternal BMI. Our findings support a reduction in the unnecessary use of vitamin and iron supplements in pregnancy, and a reversal of the trend to start vitamin and iron supplementation without any control. The increasing prevalence of obesity and excessive weight in pregnant women should be a warning against the uncontrolled usage of vitamins and iron during pregnancy.

scholarly journals The Influence of Vitamin A Supplementation on Iron Status

Nutrients ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 4399-4413 ◽  
Author(s):  
Fernanda Michelazzo ◽  
Julicristie Oliveira ◽  
Juliana Stefanello ◽  
Liania Luzia ◽  
Patricia Rondó
Keyword(s):  
Vitamin A ◽  
Iron Status ◽  
Vitamin A Supplementation

scholarly journals Impact of vitamin A supplementation in anaemia during pregnancy: a randomized double blind controlled clinical trial

2018 ◽  
Vol 7 (6) ◽  
pp. 2262
Author(s):  
Shakun Singh ◽  
Rachna Chaudhary ◽  
Vandana Dhama ◽  
Anu Singh ◽  
Urmila Karya
Keyword(s):  
Clinical Trial ◽  
Vitamin A ◽  
Pregnant Women ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Vitamin A Supplementation ◽  
Elemental Iron ◽  
Group A ◽  
Group B ◽  
The Impact

Background: To study the impact of Vitamin A supplementation in anaemia during Pregnancy and thus improving maternal and fetal outcome a Randomized double blind controlled clinical trial was conducted in Department of Obstetrics and Gynaecology, L.L.R.M. Medical college Meerut involving 250 pregnant women in late pregnancy 18-28 weeks with haemoglobin levels <11 g% (7-11 g%)..Methods: The study subjects were divided into two groups: Group A (n=125): Received daily supplement containing Iron (60 mg elemental iron) + Folate (500 mcg) + Vitamin A 20,000 IU weekly for a minimum of 12 weeks. Group B (n=125): Received daily supplement containing iron (60 mg elemental iron) + Folate (500 mcg) for a minimum of 12 weeks.Results: Maximum patients were uneducated belonging to low socioeconomic status. The mean haemoglobin values in Group A and Group B increased from 9.674±1.05 and 9.53±1.04 to 12.2±0.89 and 10.82±1.06 respectively after supplementation. Similarily Serum Ferritin levels increased from 15.96±2.94 and 15.70±2.83 to 78.40±17.82 and 58.64±11.93. Mean corpuscular volume, packed cell volume and red blood cell counts also increased significantly. Maximum haemoglobin levels were achieved with both vitamin A and iron supplementation. The proportion of women who became non anaemic was 97.17% in Group A vs 68.69% in Group B.Conclusions: Vitamin A supplementation improves anaemia and also dramatically improves iron stores in anaemic pregnant women.

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