Synthesis of chiral diaza 18-crown-6 ethers from chiral amines and molecular recognition of potassium and sodium salts of amino acids

2003 ◽  
Vol 14 (17) ◽  
pp. 2633-2637 ◽  
Author(s):  
N. Demirel ◽  
Y. Bulut
Keyword(s):  
Amino Acids ◽  
Molecular Recognition ◽  
Chiral Amines ◽  
Sodium Salts

Enantioselective Molecular Recognition of Chiral Organic Ammonium Ions and Amino Acids Using Cavitand-Salen-Based Receptors

2011 ◽  
Vol 2011 (28) ◽  
pp. 5674-5680 ◽  
Author(s):  
Maria E. Amato ◽  
Francesco P. Ballistreri ◽  
Salvatore D'Agata ◽  
Andrea Pappalardo ◽  
Gaetano A. Tomaselli ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecular Recognition ◽  
Ammonium Ions

N-DICHLOROACETYL DERIVATIVES OF SERINE AND THREONINE AND OF THEIR ESTERS AND SODIUM SALTS

1960 ◽  
Vol 38 (7) ◽  
pp. 1135-1140 ◽  
Author(s):  
I. Levi ◽  
A. E. Koller ◽  
G. Laflamme ◽  
J. W. R. Weed
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Antitumor Activity ◽  
Amino Acid Ester ◽  
Amino Group ◽  
Sodium Salts ◽  
Sarcoma 37 ◽  
Walker Carcinoma ◽  
Derivatives Of ◽  
Dichloroacetyl Chloride

The N-dichloroacetyl derivatives of DL-serine and DL-threonine were prepared by the Schotten–Baumann reaction from the amino acids and dichloroacetyl chloride. Negative ninhydrin tests coupled with elementary analyses indicated that only the amino group was acylated. The ester derivatives of these compounds were prepared either by esterification of the N-dichloroacetyl-DL-amino acid with diazomethane or by the reaction of the amino acid ester with dichloroacetyl chloride in the presence of triethylamine. The sodium salts and the esters were tested for antitumor activity against sarcoma 37 in mice and Walker carcinoma 256 in rats. In both cases regression of the tumors was obtained.

Sign in / Sign up

Export Citation Format

Share Document