Coumarin-based prodrugs. Part 3: Structural effects on the release kinetics of esterase-sensitive prodrugs of amines 1 1Part of this work was performed at the University of Oklahoma Health Sciences Center, College of Pharmacy.

1998 ◽  
Vol 6 (4) ◽  
pp. 417-426 ◽  
Author(s):  
Binghe Wang ◽  
Huijuan Zhang ◽  
Ailian Zheng ◽  
Wei Wang
Keyword(s):  
Release Kinetics ◽  
Health Sciences ◽  
Structural Effects ◽  
University Of Oklahoma ◽  
Oklahoma Health ◽  
The University ◽  
Kinetics Of

Management Protocol for Abacavir-Related Hypersensitivity Reaction

2000 ◽  
Vol 34 (2) ◽  
pp. 247-249 ◽  
Author(s):  
Patrick G Clay ◽  
R Chris Rathbun ◽  
Leonard N Slater
Keyword(s):  
Hypersensitivity Reaction ◽  
Health Sciences ◽  
Response Mechanism ◽  
Data Synthesis ◽  
University Of Oklahoma ◽  
Management Procedure ◽  
Management Protocol ◽  
Oklahoma Health ◽  
The University

OBJECTIVE: To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center. DATA SYNTHESIS: Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions. RESULTS: Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians. CONCLUSIONS: Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure

Early Management and Decision Making for the Treatment of Myelomeningocele

PEDIATRICS ◽  
1983 ◽  
Vol 72 (4) ◽  
pp. 450-458 ◽  
Author(s):  
Richard H. Gross ◽  
Alan Cox ◽  
Ruth Tatyrek ◽  
Michael Pollay ◽  
William A. Barnes
Keyword(s):  
Supportive Care ◽  
Early Selection ◽  
Early Management ◽  
Ethical Concerns ◽  
University Of Oklahoma ◽  
Legal Custody ◽  
Oklahoma Health ◽  
The University ◽  
Vigorous Treatment

A program for early selection and treatment of the infant with myelomeningocele was developed at the University of Oklahoma Health Sciences Center in 1977. Over a 5-year period, 69 babies were evaluated, 36 babies were recommended for early vigorous treatment. Of the 33 babies for whom only supportive care was recommended, five were initially treated at the parents' request, two underwent delayed vigorous treatment, one was subsequently treated by "crisis management," one moved and did not return for follow-up, and 24 received only supportive care. All 24 babies died between 1 to 189 days of age (mean 37 days). The involvement of several physicians and paramedical support personnel is considered essential for this approach of early selection and treatment. Continued support and regular follow-up is necessary for any baby who receives only supportive care. Parents retain legal custody. Although ethical concerns make any approach difficult, the method presented is considered to be the best alternative available at this time.

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