In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT

2001 ◽  
Vol 28 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Michael Kassiou ◽  
Stefan Eberl ◽  
Steven R Meikle ◽  
Alex Birrell ◽  
Chris Constable ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Nicotinic Receptor ◽  
Nicotine Treatment ◽  
Chronic Nicotine ◽  
Chronic Nicotine Treatment ◽  
Receptor Upregulation

scholarly journals Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures

2021 ◽  
Vol 22 (9) ◽  
pp. 4775
Author(s):  
Cristiano Bombardi ◽  
Francis Delicata ◽  
Claudio Tagliavia ◽  
Annamaria Grandis ◽  
Massimo Pierucci ◽  
...  
Keyword(s):  
Drug Target ◽  
Nicotine Addiction ◽  
The Other ◽  
Nicotine Exposure ◽  
Receptor Function ◽  
Lateral Habenula ◽  
Nicotine Treatment ◽  
Chronic Nicotine ◽  
Chronic Nicotine Treatment

Serotonin (5-HT) is important in some nicotine actions in the CNS. Among all the 5-HT receptors (5-HTRs), the 5-HT2CR has emerged as a promising drug target for smoking cessation. The 5-HT2CRs within the lateral habenula (LHb) may be crucial for nicotine addiction. Here we showed that after acute nicotine tartrate (2 mg/kg, i.p.) exposure, the 5-HT2CR agonist Ro 60-0175 (5–640 µg/kg, i.v.) increased the electrical activity of 42% of the LHb recorded neurons in vivo in rats. Conversely, after chronic nicotine treatment (6 mg/kg/day, i.p., for 14 days), Ro 60-0175 was incapable of affecting the LHb neuronal discharge. Moreover, acute nicotine exposure increased the 5-HT2CR-immunoreactive (IR) area while decreasing the number of 5-HT2CR-IR neurons in the LHb. On the other hand, chronic nicotine increased both the 5-HT2CR-IR area and 5-HT2CR-IR LHb neurons in the LHb. Western blot analysis confirmed these findings and further revealed an increase of 5-HT2CR expression in the medial prefrontal cortex after chronic nicotine exposure not detected by the immunohistochemistry. Altogether, these data show that acute and chronic nicotine exposure differentially affect the central 5-HT2CR function mainly in the LHb and this may be relevant in nicotine addiction and its treatment.

scholarly journals Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 ◽  
Vol 12 (7) ◽  
pp. 2765-2784 ◽  
Author(s):  
MJ Marks ◽  
JR Pauly ◽  
SD Gross ◽  
ES Deneris ◽  
I Hermans-Borgmeyer ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Receptor Subunit ◽  
Nicotine Treatment ◽  
Chronic Nicotine ◽  
Chronic Nicotine Treatment
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