Evaluation of global cardiac systolic performance and diastolic filling in central hypovolumia by lower body negative pressure with Doppler echocardiography

2007 ◽  
Vol 21 (4) ◽  
pp. 227-232
Author(s):  
Baomin Liu ◽  
Xiaolin Niu ◽  
Benyu Jiang ◽  
Mike Seddon ◽  
Keren McNeil ◽  
...  
Keyword(s):  
Doppler Echocardiography ◽  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Diastolic Filling ◽  
Lower Body ◽  
Systolic Performance

Simulation of cardiovascular response to lower body negative pressure from 0 to -40 mmHg

1994 ◽  
Vol 77 (2) ◽  
pp. 630-640 ◽  
Author(s):  
F. M. Melchior ◽  
R. S. Srinivasan ◽  
P. H. Thullier ◽  
J. M. Clere
Keyword(s):  
Heart Rate ◽  
Negative Pressure ◽  
Baroreflex Sensitivity ◽  
Lower Body Negative Pressure ◽  
Cardiovascular Response ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Lower Body ◽  
Arterial Baroreflex ◽  
Arterial Baroreflex Sensitivity

This paper presents a mathematical model for simulation of the human cardiovascular response to lower body negative pressure (LBNP) up to -40 mmHg both under normal conditions and when arterial baroreflex sensitivity or leg blood capacity (LBC) is altered. Development of the model assumes that the LBNP response could be explained solely on the bases of 1) blood volume redistribution, 2) left ventricular end-diastolic filling, 3) interaction between left ventricle and peripheral circulation, and 4) modulations of peripheral resistances and heart rate by arterial and cardiopulmonary baroreflexes. The model reproduced well experimental data obtained both under normal conditions and during complete autonomic blockade; thus it is validated for simulation of the cardiovascular response from 0 to -40 mmHg LBNP. We tested the ability of the model to simulate the changes in LBNP response due to a reduction in LBC. To assess these changes experimentally, six healthy men were subjected to LBNP of -15, -30, and -38 mmHg with and without wearing elastic compression stockings. Stockings significantly reduced LBC (from 3.9 +/- 0.3 to 1.8 +/- 0.4 ml/100 ml tissue at -38 mmHg LBNP; P < 0.01) and attenuated the change in heart rate (from 23 +/- 4 to 8 +/- 3% at -38 mmHg LBNP; P < 0.05). The model accurately reproduced this result. The model is useful for assessing the influence of LBC or other parameters such as arterial baroreflex sensitivity in diminishing the orthostatic tolerance of humans after spaceflight, bed rest, or endurance training.

Neurohormonal responses to oscillatory lower body negative pressure in healthy subjects

2021 ◽  
Author(s):  
Akanksha Singh ◽  
Shival Srivastav ◽  
Kavita Yadav ◽  
Dinu S. Chandran ◽  
Ashok Kumar Jaryal ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Healthy Subjects ◽  
Lower Body Negative Pressure ◽  
Lower Body

Bradykinin has no acute effect on the response of forearm blood flow to sympathetic stimulation in man

1990 ◽  
Vol 78 (4) ◽  
pp. 399-401 ◽  
Author(s):  
M. J. Cullen ◽  
J. R. Cockcroft ◽  
D. J. Webb
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Negative Pressure ◽  
Enzyme Inhibitor ◽  
Lower Body Negative Pressure ◽  
Acute Effect ◽  
Acute Administration ◽  
Lower Body ◽  
Resistance Vessels ◽  
Sympathetic Responses

1. Six healthy male subjects received 0.9% (w/v) NaCl (saline) followed by incremental doses of bradykinin (1, 3 and 10 pmol/min), via the left brachial artery. Blood flow and the response of blood flow to lower-body negative pressure were measured in both forearms during infusion of saline and each dose of bradykinin. 2. Bradykinin produced a moderate and dose-dependent increase in blood flow in the infused, but not the non-infused, forearm. Lower-body negative pressure produced an approximately 15–20% reduction in blood flow in both forearms, and this response was unaffected by local infusion of bradykinin. 3. Bradykinin, in contrast to angiotensin II, had no acute effect on peripheral sympathetic responses to lower-body negative pressure. We conclude that, in forearm resistance vessels in man, withdrawal of angiotensin II, rather than accumulation of bradykinin, is likely to account for the attenuation of peripheral sympathetic responses after acute administration of a converting-enzyme inhibitor.

The impact of menopausal status on cardiac responses to exercise training and lower body negative pressure

Maturitas ◽  
2017 ◽  
Vol 103 ◽  
pp. 91
Author(s):  
Amanda Q.X. Nio ◽  
Eric J. Stöhr ◽  
Samantha Rogers ◽  
Rachel Mynors-Wallis ◽  
Jane M. Black ◽  
...  
Keyword(s):  
Exercise Training ◽  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Menopausal Status ◽  
Lower Body ◽  
Cardiac Responses ◽  
The Impact

VASOCONSTRICTOR RESPONSE TO LOWER BODY NEGATIVE PRESSURE DURING AUTONCMIC BLOCKADE

1986 ◽  
Vol 18 (supplement) ◽  
pp. S15
Author(s):  
H. L. Smith ◽  
D. L. Hudson ◽  
H. M. Graitzer ◽  
P. B. Raven
Keyword(s):  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Lower Body ◽  
Vasoconstrictor Response
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