Frontal and Cerebellar Co-activation during a Verbal Working Memory Task as revealed by Functional MRI

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S856
Author(s):  
N. Yamanouchi ◽  
A. Murakami ◽  
K. Kodama ◽  
S. Noda ◽  
S. Okada ◽  
...  
2018 ◽  
pp. 825-829 ◽  
Author(s):  
Z. TÜDÖS ◽  
P. HOK ◽  
P. HLUŠTÍK ◽  
A. GRAMBAL

Neuroimaging methods have been used to study differences of brain function between males and females. Differences in working memory have been also investigated, but results of such studies are mixed with respect to behavioral data, reaction times and activated brain areas. We tried to analyze functional MRI data acquired during the working memory task and search for differences of brain activation between genders. 20 healthy right-handed volunteers (10 males and 10 females) participated in the study. All of them were university students or fresh graduates. Subjects underwent block designed verbal working memory task (Item Recognition Task) inside the MRI scanner. Standard single-subject pre-processing and group fMRI analyses were performed using the FEAT software from FSL library. In the behavioral data, there was no statistically significant difference in the number of correct responses during the task. The task activated similar bilateral regions of frontal, parietal, temporal and occipital lobes, basal ganglia, the brainstem and in the cerebellum, which corresponds to the previous verbal working memory neuroimaging research. In direct comparison, there was no statistically significant difference in brain activation between small samples of male and female young healthy volunteers.


NeuroImage ◽  
2004 ◽  
Vol 21 (3) ◽  
pp. 1000-1008 ◽  
Author(s):  
Xingchang Wei ◽  
Seung-Schik Yoo ◽  
Chandlee C. Dickey ◽  
Kelly H. Zou ◽  
Charles R.G. Guttmann ◽  
...  

1996 ◽  
Author(s):  
Alexandra Gottardo ◽  
Keith E. Stanovich ◽  
Linda S. Siegel

1994 ◽  
Vol 1 (4) ◽  
pp. 293-304 ◽  
Author(s):  
Jonathan D. Cohen ◽  
Steven D. Forman ◽  
Todd S. Braver ◽  
B. J. Casey ◽  
David Servan-Schreiber ◽  
...  

1997 ◽  
Vol 17 (24) ◽  
pp. 9675-9685 ◽  
Author(s):  
John E. Desmond ◽  
John D. E. Gabrieli ◽  
Anthony D. Wagner ◽  
Bruce L. Ginier ◽  
Gary H. Glover

NeuroImage ◽  
2013 ◽  
Vol 67 ◽  
pp. 25-32 ◽  
Author(s):  
Toshihiko Aso ◽  
Shin-ichi Urayama ◽  
Hidenao Fukuyama ◽  
Denis Le Bihan

2003 ◽  
Vol 33 (6) ◽  
pp. 1007-1018 ◽  
Author(s):  
G. D. HONEY ◽  
T. SHARMA ◽  
J. SUCKLING ◽  
V. GIAMPIETRO ◽  
W. SONI ◽  
...  

Background. There is considerable variability between patients in their expression of the diverse range of symptoms encompassed by the syndrome of schizophrenia, which may modulate functional activation to cognitive processing.Method. Here we investigate associations between schizophrenic subsyndrome scores, identified by factor analysis, and experimentally controlled brain activation. Five factors were defined by rotated principal components analysis of PANSS rating scale measurements in 100 patients with schizophrenia. A subsample of 30 patients and a group of 27 comparison subjects were studied using functional magnetic resonance imaging (fMRI) during the performance of two periodically designed cognitive activation experiments: verbal working memory and psychomotor sequencing.Results. Factor analysis replicated the five dimensions consistently reported. Within the patient group, power of activation by working memory was negatively associated with global symptom severity in left lingual and temporo-parietal cortices; negatively associated with positive subsyndrome scores in left inferior frontal and superior temporal cortices and basal ganglia; and positively associated with negative subsyndrome scores in lateral and medial premotor cortex. No relationship was observed between subsyndrome scores and functional activation during the motor task. Between-group comparisons demonstrated reduced power of response to the working memory task by patients in bilateral dorsolateral prefrontal and left pre- and post-central cortices.Conclusions. In this study we observed task-specific modulation of functional response associated with symptom expression in schizophrenia. Our findings are compatible with previous empirical findings and theoretical conceptualization of human brain function, in terms of capacity constraints on activation in the face of competing demands from pathological and task-related cognitive activity.


NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 1106
Author(s):  
Jill M. Thompson ◽  
Paul J. Monkst ◽  
Adrian J. Lloyd ◽  
C. Louise Harrison ◽  
Ed T. Bulhnoret ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Shawn E. Christ ◽  
Janine P. Stichter ◽  
Karen V. O’Connor ◽  
Kimberly Bodner ◽  
Amanda J. Moffitt ◽  
...  

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication. It has been postulated that such difficulties are related to disruptions in underlying cognitive processes such as executive function. The present study examined potential changes in executive function performance associated with participation in the Social Competence Intervention (SCI) program, a short-term intervention designed to improve social competence in adolescents with ASD. Laboratory behavioral performance measures were used to separately evaluate potential intervention-related changes in individual executive function component processes (i.e., working memory, inhibitory control, and cognitive flexibility) in a sample of 22 adolescents with ASD both before and after intervention. For comparison purposes, a demographically matched sample of 14 individuals without ASD was assessed at identical time intervals. Intervention-related improvements were observed on the working memory task, with gains evident in spatial working memory and, to a slightly lesser degree, verbal working memory. Significant improvements were also found for a working memory-related aspect of the task switching test (i.e., mixing costs). Taken together, these findings provide preliminary support for the hypothesis that participation in the SCI program is accompanied by changes in underlying neurocognitive processes such as working memory.


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