Evolution of the human killer cell inhibitory receptor family

2002 ◽  
Vol 25 (2) ◽  
pp. 330-340 ◽  
Author(s):  
A HUGHES
Keyword(s):  
Killer Cell ◽  
Inhibitory Receptor ◽  
Receptor Family ◽  
Killer Cell Inhibitory Receptor

Gene arrangement of the killer cell inhibitory receptor family on human chromosome 19q13.4 detected by fiber-FISH

1998 ◽  
Vol 48 (4) ◽  
pp. 235-241 ◽  
Author(s):  
Y. Suto ◽  
Yoshihide Ishikawa ◽  
Masanori Kasahara ◽  
Fumio Kasai ◽  
Toshio Yabe ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Killer Cell ◽  
Gene Arrangement ◽  
Inhibitory Receptor ◽  
Receptor Family ◽  
Killer Cell Inhibitory Receptor

Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2)

1998 ◽  
Vol 54 (3) ◽  
pp. 433-435 ◽  
Author(s):  
Katsumi Maenaka ◽  
Takeo Juji ◽  
Kenji Tadokoro ◽  
Karl Harlos ◽  
David I. Stuart ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Killer Cell ◽  
Hla Class I ◽  
Immunoglobulin Superfamily ◽  
Diffusion Method ◽  
Inhibitory Receptor ◽  
Data Set ◽  
Extracellular Region ◽  
Hla Class I Molecules ◽  
Killer Cell Inhibitory Receptor

Molecules of the human killer cell inhibitory receptor (KIR) family, which belong to the immunoglobulin superfamily (IgSF), are expressed on the surface of natural killer (NK) cells and some subsets of T cells. These receptors function to mediate the inhibition or activation of cytotoxic activity by recognizing HLA class I molecules on the target cell. The extracellular region of a p58 KIR specific for HLA-Cw1,3,7 (KIR2) has been overproduced in Escherichia coli and purified. The recombinant KIR2 has been crystallized in 9–10% poly(ethylene glycol) methyl ether (average Mr = 8000), 50mM HEPES, 8% ethylene glycol, 0.5% octyl-β-glucoside, pH 7.5, at 294 K using the sitting-drop vapour-diffusion method. Preliminary X-ray diffraction studies reveal the space group to be hexagonal (P6122 or P6522) with lattice constants a = b = 95.3, c = 130.8 Å. A native data set (3 Å resolution) has been collected at the Photon Factory (λ = 1.0 Å).

The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 ◽  
Vol 27 (2) ◽  
pp. 563-567 ◽  
Author(s):  
Marta Carretero ◽  
Claudia Cantoni ◽  
Teresa Bellón ◽  
Cristina Bottino ◽  
Roberto Biassoni ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Hla Class I ◽  
Class I ◽  
Inhibitory Receptor ◽  
Hla Class I Molecules ◽  
Killer Cell Inhibitory Receptor
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