Human first trimester fetal ovaries express oncofetal antigens and steroid receptors

2000 ◽  
Vol 7 (2) ◽  
pp. 131-138 ◽  
Author(s):  
D Gould
Keyword(s):  
Steroid Receptors ◽  
First Trimester ◽  
Oncofetal Antigens

Human First Trimester Fetal Ovaries Express Oncofetal Antigens and Steroid Receptors

2000 ◽  
Vol 7 (2) ◽  
pp. 131-138 ◽  
Author(s):  
D. A. Gould ◽  
G. J. Moscoso ◽  
M. P. A. Young ◽  
D. P. J. Barton
Keyword(s):  
Steroid Receptors ◽  
First Trimester ◽  
Oncofetal Antigens

Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception

2009 ◽  
Vol 91 (4) ◽  
pp. 1420-1423 ◽  
Author(s):  
Chun-Xia Meng ◽  
Li-Nan Cheng ◽  
Parameswaran Grace Luther Lalitkumar ◽  
Lin Zhang ◽  
Hui-Juan Zhang ◽  
...  
Keyword(s):  
Emergency Contraception ◽  
Steroid Receptors ◽  
First Trimester ◽  
Chorionic Villi

Role of molecular chaperones in steroid receptor action

2004 ◽  
Vol 40 ◽  
pp. 41-58 ◽  
Author(s):  
William B Pratt ◽  
Mario D Galigniana ◽  
Yoshihiro Morishima ◽  
Patrick J M Murphy
Keyword(s):  
Transcriptional Activation ◽  
Protein Trafficking ◽  
Steroid Receptors ◽  
Transcriptional Regulatory ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Receptor Action ◽  
Binding Cleft ◽  
Hsp 90

Unliganded steroid receptors are assembled into heterocomplexes with heat-shock protein (hsp) 90 by a multiprotein chaperone machinery. In addition to binding the receptors at the chaperone site, hsp90 binds cofactors at other sites that are part of the assembly machinery, as well as immunophilins that connect the assembled receptor-hsp90 heterocomplexes to a protein trafficking pathway. The hsp90-/hsp70-based chaperone machinery interacts with the unliganded glucocorticoid receptor to open the steroid-binding cleft to access by a steroid, and the machinery interacts in very dynamic fashion with the liganded, transformed receptor to facilitate its translocation along microtubular highways to the nucleus. In the nucleus, the chaperone machinery interacts with the receptor in transcriptional regulatory complexes after hormone dissociation to release the receptor and terminate transcriptional activation. By forming heterocomplexes with hsp90, the chaperone machinery stabilizes the receptor to degradation by the ubiquitin-proteasome pathway of proteolysis.

First-Trimester Screening: State of the Art Is Standard of Care

Ob Gyn News ◽  
2011 ◽  
Vol 46 (5) ◽  
pp. 22-23
Author(s):  
CHRISTOPHER R. HARMAN ◽  
E. ALBERT REECE
Keyword(s):  
State Of The Art ◽  
Standard Of Care ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening

First-Trimester Stress May Prompt Early Delivery

Ob Gyn News ◽  
2005 ◽  
Vol 40 (4) ◽  
pp. 12
Author(s):  
BETSY BATES
Keyword(s):  
First Trimester

First-Trimester Doppler Predicts IUGR

Ob Gyn News ◽  
2005 ◽  
Vol 40 (8) ◽  
pp. 4
Author(s):  
Timothy F. Kirn
Keyword(s):  
First Trimester
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