The long term outcome of feminizing genital surgery for congenital adrenal hyperplasia: anatomical, functional and cosmetic outcomes, psychosexual development, and satisfaction in adult female patients

2003 ◽  
Vol 16 (5) ◽  
pp. 289-296 ◽  
Author(s):  
Nike M.M.L Stikkelbroeck ◽  
Catharina C.M Beerendonk ◽  
Wim N.P Willemsen ◽  
Conny A Schreuders-Bais ◽  
Wouter F.J Feitz ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Female ◽  
Psychosexual Development ◽  
Adrenal Hyperplasia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Genital Surgery ◽  
Female Patients ◽  
Cosmetic Outcomes

scholarly journals Long-term outcome of genital reconstruction of Middle Eastern women with congenital adrenal hyperplasia

2013 ◽  
Vol 5 (4) ◽  
pp. 277 ◽  
Author(s):  
RaoufM Seyam ◽  
NabilK Bissada ◽  
Mohamed Abdul-Aaly ◽  
NadiaA Sakati ◽  
Waleed Al Taweel ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Middle Eastern ◽  
Adrenal Hyperplasia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Middle Eastern Women

Long-Term Outcome of Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

2006 ◽  
Vol 67 (6) ◽  
pp. 268-276 ◽  
Author(s):  
Anne Bachelot ◽  
Geneviève Plu-Bureau ◽  
Elisabeth Thibaud ◽  
Kathleen Laborde ◽  
Graziella Pinto ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Term Outcome ◽  
Long Term Outcome ◽  
21 Hydroxylase Deficiency

Long-Term Outcome in Congenital Adrenal Hyperplasia: Gender and Sexuality

2003 ◽  
Vol 13 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Heino F. L. Meyer-Bahlburg ◽  
Susan W. Baker ◽  
Curtis Dolezal ◽  
Ann D. Carlson ◽  
Jihad S. Obeid ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Gender And Sexuality ◽  
Adrenal Hyperplasia ◽  
Term Outcome ◽  
Long Term Outcome

Prenatal Treatment of Congenital Adrenal Hyperplasia: Long-Term Effects of Excess Glucocorticoid Exposure

2018 ◽  
Vol 89 (5) ◽  
pp. 362-371 ◽  
Author(s):  
Svetlana Lajic ◽  
Leif Karlsson ◽  
Anna Nordenström
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Experimental Studies ◽  
External Genitalia ◽  
Prenatal Treatment ◽  
Adrenal Hyperplasia ◽  
Long Term Effects ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Negative Effect

Prenatal treatment of congenital adrenal hyperplasia with dexamethasone (DEX) has been in use since the mid-1980s and has proven effective at reducing virilization of external genitalia in affected girls. However, multiple experimental studies on animals and clinical studies on humans show that prenatal administration of glucocorticoids may cause unwanted adverse effects which have raised concerns about the long-term safety of the treatment. The long-term outcome of prenatal DEX treatment on cognition has been investigated, but the results are still conflicting. Overall, most of the evidence points towards a negative effect on executive functions where girls seem to be more susceptible than boys. Some effects on social behavior have been observed, but results are still contradictory and treated children are mostly well adapted. Cardiovascular, renal, and metabolic function are still areas to be investigated. Larger studies are warranted to investigate areas other than cognition and behavior and to be able to draw more definitive conclusions about prenatal DEX treatment.

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