scholarly journals 82 Macrophage migration inhibitory factor plays an important role in the host innate immune defenses against Candida infection

2006 ◽  
Vol 10 ◽  
pp. S46-S47 ◽  
Author(s):  
C. Nicolo ◽  
D. Le Roy ◽  
M.K. Reymond ◽  
T. Roger ◽  
T. Calandra
2005 ◽  
Vol 73 (6) ◽  
pp. 3783-3786 ◽  
Author(s):  
Mauro Oddo ◽  
Thierry Calandra ◽  
Richard Bucala ◽  
Pascal R. A. Meylan

ABSTRACT Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.


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