scholarly journals Macrophage Migration Inhibitory Factor and Host Innate Immune Defenses against Bacterial Sepsis

2003 ◽  
Vol 187 (s2) ◽  
pp. S385-S390 ◽  
Author(s):  
Thierry Calandra ◽  
Céline Froidevaux ◽  
Christian Martin ◽  
Thierry Roger
Keyword(s):  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Innate Immune ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Bacterial Sepsis ◽  
Immune Defenses

scholarly journals Macrophage Migration Inhibitory Factor Reduces the Growth of Virulent Mycobacterium tuberculosis in Human Macrophages

2005 ◽  
Vol 73 (6) ◽  
pp. 3783-3786 ◽  
Author(s):  
Mauro Oddo ◽  
Thierry Calandra ◽  
Richard Bucala ◽  
Pascal R. A. Meylan
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Migration Inhibitory Factor ◽  
Innate Immune System ◽  
Host Response ◽  
Macrophage Migration Inhibitory Factor ◽  
Bacterial Infections ◽  
Innate Immune ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Human Macrophages

ABSTRACT Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.

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