Aim. To investigate the effect of 0.1% taurine on the manifestation of muscular dystrophy in Drosophila melanogaster mutants under both larval and adult feeding. Methods. Larval and adult feeding of 0.1 % taurine, construction of survival curves and study of moving activity, making thorax muscles histological preparations. Results. It has been shown the increasing of life span indexes (on 46-75%). moving activity (on 50-75%), decreasing of fatigue rates, and reducing of muscle damages (on 6-20%) in Drosophila dystrophy mutants under the influence of 0.1% taurine. Conclusions. The results indicate a positive effect of 0.1% taurine as a stimulant, antioxidant, myoprotector, blocker of fatigue processes in dystrophin mutants. However, following further studies on vertebrates, taurine may be recommended as a therapeutic agent in the treatment of Duchenne muscular dystrophy.
Keywords: Drosophila, dystrophin, miodystrophy, taurine.
769. Laminin-111: A Highly Potent Therapeutic Agent To Treat Duchenne Muscular Dystrophy
