Abstract #277: Immunogenicity in a Patient with DKA: Do Insulin Antibodies Influence Response to Recombinant But Not Analog Insulin?

2016 ◽  
Vol 22 ◽  
pp. 71
Author(s):  
Tara Kim ◽  
Patricia Garnica ◽  
Alyson Myers
Keyword(s):  
Insulin Antibodies ◽  
Analog Insulin

PLACENTAL TRANSFER OF INSULIN-131I IN GUINEA PIGS IMMUNIZED AGAINST INSULIN

1966 ◽  
Vol 52 (2) ◽  
pp. 276-291 ◽  
Author(s):  
Jan I. Thorell
Keyword(s):  
Plasma Concentration ◽  
Guinea Pigs ◽  
Placental Transfer ◽  
Maternal Plasma ◽  
Insulin Antibodies ◽  
Insulin Antibody

ABSTRACT The placenta is considered to be impermeable or only slightly permeable to insulin. Insulin antibodies are transferred from mother to foetus in man and in guinea pigs. The passage of insulin-131I from mother to foetus was studied in guinea pigs with and without antibodies against insulin. Antibody-bound insulin-131I was recovered in plasma from foetuses of immunized pregnant guinea pigs, at intervals of more than 5 hours after the injection of insulin-131I to the mother. The foetal levels of insulin-131I were rather low, the highest recorded value being 27% of the maternal plasma concentration. This peak was reached 32 hours after the injection. No insulin-131I was found in the foetuses of non-immunized guinea pigs.

scholarly journals Severe Insulin-resistant Diabetes due to Insulin Antibodies Associated with Eosinophilia

2015 ◽  
Vol 54 (18) ◽  
pp. 2367-2371 ◽  
Author(s):  
Makiyo Takaya ◽  
Mototsugu Nagao ◽  
Shuji Takemitsu ◽  
Yasushi Nakajima ◽  
Hitoshi Sugihara ◽  
...  
Keyword(s):  
Insulin Antibodies ◽  
Insulin Resistant

Influence of Anti-Insulin Antibodies on Insulin Immunoassays in the Autoimmune Insulin Syndrome

1998 ◽  
Vol 35 (6) ◽  
pp. 768-774 ◽  
Author(s):  
A. Casesnoves ◽  
M. Mauri ◽  
J. R. Dominguez ◽  
R. Alfayate ◽  
A. M. Pico
Keyword(s):  
Insulin Antibodies

Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies

2009 ◽  
Vol 84 (2) ◽  
pp. e21-e23 ◽  
Author(s):  
Tsuneo Ishizuka ◽  
Susumu Ogawa ◽  
Takefumi Mori ◽  
Kazuhiro Nako ◽  
Takashi Nakamichi ◽  
...  
Keyword(s):  
Insulin Antibodies

scholarly journals Primary insulin autoimmune syndrome in an Italian woman: a case report

2015 ◽  
Vol 9 (2) ◽  
pp. 169 ◽  
Author(s):  
Antonio Balestrieri ◽  
Elena Magnani ◽  
Cecilia Ragazzini ◽  
Giampiero Pasini
Keyword(s):  
Case Report ◽  
Insulin Antibodies ◽  
Total Serum ◽  
Immunoreactive Insulin ◽  
High Concentration ◽  
Hematological Diseases ◽  
Italian Woman ◽  
Insulin Autoimmune Syndrome ◽  
Autoimmune Syndrome ◽  
Primary Form

Insulin autoimmune syndrome (IAS) is a rare syndrome characterized by fasting or postprandial hypoglycemia, high levels of anti-insulin antibodies and high concentration of total serum immunoreactive insulin. It is relatively known in Japan, rare in remaining Asia and it is extremely uncommon in Western countries, being characterized by a different race-related incidence and associated with HLADR4 alleles. Usually IAS is related to particular drugs, or to autoimmune, rheumatologic or hematological diseases, while it is very rare as a primary form. Here we described a case of an Italian woman affected by a primary form of Hirata syndrome.

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