3P-0811 LDL-cholesterol-lowering effects of a mixed green vegetable and fruit beverage containing broccoli and cabbage in hypercholesterolemic subjects

2003 ◽  
Vol 4 (2) ◽  
pp. 239
Author(s):  
M. Takai ◽  
H. Suido ◽  
T. Tanaka ◽  
M. Kotani ◽  
A. Fujita ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Green Vegetable ◽  
Hypercholesterolemic Subjects

scholarly journals Effect of Mixed-Tocotrienols in Hypercholesterolemic Subjects

2011 ◽  
Vol 1 (3) ◽  
pp. 106 ◽  
Author(s):  
Kah Hay Yuen ◽  
Jia Woei Wong ◽  
Ai Beoy Lim ◽  
Bee Hong Ng ◽  
Wai Peng Choy
Keyword(s):  
Placebo Group ◽  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Fold Increase ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Hypercholesterolemic Subjects ◽  
Lowering Activity

Background: Studies on the cholesterol lowering activity of tocotrienols have yielded mixed results, with some showing cholesterol lowering effect while some showing no activity.Aim: A randomized, double-blind, parallel group study was conducted to investigate the cholesterol lowering activity of tocotrienols. Methods: Thirty-two hypercholesterolemic subjects were randomly assigned to orally receive either 300 mg of mixed tocotrienols capsules daily or placebo capsules containing 300 mg of soya bean oil for a period of 6 months. The subjects were monitored before supplementation and monthly thereafter for their serum cholesterol as well as tocotrienol and tocopherol concentrations.Results: The serum total cholesterol and low density lipoprotein (LDL) cholesterol of the subjects in the tocotrienol supplementation group were decreased significantly by -8.9 ± 0.9% and -12.8 ± 2.6% respectively after 4 months of supplementation and the reduction persisted till the end of the 6-month study, with a reduction of -10.8 ± 1.0% and  -17.3 ± 1.8%, respectively from baseline. Moreover, there was a 22-fold increase in the total tocotrienol concentrations from baseline during supplementation compared to the placebo group, while the concentration of α-tocopherol recorded only a modest increase. On the other hand, the serum cholesterol, total tocotrienol and α-tocopherol concentrations of subjects in the placebo group remained essentially unchanged.Conclusions: Supplementation with mixed tocotrienols at dose of 300 mg per day resulted in the lowering of the serum total and LDL cholesterol levels after 5 months of supplementation.Keywords: tocotrienols, cholesterol-lowering, total cholesterol, LDL cholesterol, tocopherols

scholarly journals Cereal-Based Snack Bar with Added Plant Stanol Ester (Benecol®) Consumed between Meals Lowers Serum Total and LDL Cholesterol Effectively in Mildly to Moderately Hypercholesterolemic Subjects

Cholesterol ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Essi Sarkkinen ◽  
Mari Lyyra ◽  
Sakari Nieminen ◽  
Päivi Kuusisto ◽  
Ingmar Wester
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Parallel Design ◽  
Plant Stanol ◽  
Habitual Diet ◽  
Stanol Ester ◽  
Hypercholesterolemic Subjects

The cholesterol-lowering effect of foods with added plant sterols or stanols consumed as snacks might be compromised. The purpose of this study was to confirm the cholesterol-lowering efficacy of a specially formulated cereal-based snack bar with added plant stanol ester (1.6 g plant stanols/day) when consumed between meals twice a day. In a double-blind, placebo-controlled, 4-week parallel-design study, 71 mildly to moderately hypercholesterolemic subjects were randomized into one of two groups, stanol or placebo group. Subjects were advised to replace their ordinary snacks with test products in an isocaloric manner and otherwise keep their habitual diet unchanged. The study showed that a snack bar product with added plant stanol ester lowered LDL and non-HDL cholesterol by 8.6% and 9.2% (mean%-change), respectively, as compared to the placebo product. The change in LDL cholesterol was statistically significantly different (P=0.001) between the groups while the change in HDL cholesterol or triglycerides did not differ between the groups. In conclusion, the cereal-based snack bar with added plant stanol ester ingested without a meal reduced LDL cholesterol significantly without affecting HDL cholesterol or triglyceride concentrations in mildly hypercholesterolemic men and women. The study is registered as NCT03284918.

Serum LDL-Cholesterol-Lowering Effects of a Mixed Green Vegetable and Fruit Beverage Containing Broccoli and Cabbage in Humans

2008 ◽  
pp. 435-445
Author(s):  
Hirohisa Suido ◽  
Motoko Takai ◽  
Akira Takeuchi ◽  
Taketoshi Makino ◽  
Keisuke Tsuji ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Green Vegetable

scholarly journals Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression

2017 ◽  
Vol 10 (4) ◽  
pp. 437-446 ◽  
Author(s):  
Sanghoon Shin ◽  
Hyung-Bok Park ◽  
Hyuk-Jae Chang ◽  
Reza Arsanjani ◽  
James K. Min ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Atherosclerosis Progression ◽  
Coronary Artery Atherosclerosis

Increased Superoxide Anion Production by Platelets in Hypercholesterolemic Patients

2002 ◽  
Vol 87 (05) ◽  
pp. 796-801 ◽  
Author(s):  
Valerio Sanguigni ◽  
Pasquale Pignatelli ◽  
Daniela Caccese ◽  
Fabio Pulcinelli ◽  
Luisa Lenti ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Ldl Cholesterol ◽  
Experimental Studies ◽  
Human Platelets ◽  
Superoxide Anion Production ◽  
Cholesterol Lowering ◽  
Platelet Production ◽  
Cholesterol Levels ◽  
Anion Production ◽  
O2 Production

SummaryThe purpose of this study was to investigate the relationship between hypercholesterolemia and superoxide anion production.Experimental studies demonstrated that hypercholesterolemia is associated with enhanced cellular superoxide anion (O2 −) production. Aim of the study was to assess whether the same phenomenon occurs in humans.Lipid profile and platelet O2 − production were measured in 28 patients with hypercholesterolemia, compared with 25 age- and sexmatched healthy subjects, and in 21 out of the 28 patients after 8-week treatment with 10 mg/day atorvastatin (a HMGCoA reductase inhibitor). In order to assess the mechanism by which LDL cholesterol interferes with platelet production of O2 −, human platelets were incubated with LDL cholesterol in the presence of either an inhibitor of the phospholipaseA2 enzyme, AACOCF3, or an inhibitor of NADH/NADPH oxidases, DPI.O2 − platelet generation was significantly higher (p <0.001) and significantly related to LDL cholesterol (p < 0.001 ) in patients as compared to controls. 8-week treatment with 10 mg/day atorvastatin significantly reduced both LDL cholesterol and O2 − platelet production. This effect was partially related to the cholesterol-lowering, in that three days of treatment with atorvastatin significantly decreased platelet O2 − production, while no significant change in LDL-cholesterol levels was observed. Platelets incubated with LDL cholesterol showed O2 − release by atorvastatin is partially related to cholesterol lowering effect, suggesting that other mechanisms could be responsible for the antioxidant activity of the drug.

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