Serum LDL-Cholesterol-Lowering Effects of a Mixed Green Vegetable and Fruit Beverage Containing Broccoli and Cabbage in Humans

2008 ◽  
pp. 435-445
Author(s):  
Hirohisa Suido ◽  
Motoko Takai ◽  
Akira Takeuchi ◽  
Taketoshi Makino ◽  
Keisuke Tsuji ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Green Vegetable

scholarly journals Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression

2017 ◽  
Vol 10 (4) ◽  
pp. 437-446 ◽  
Author(s):  
Sanghoon Shin ◽  
Hyung-Bok Park ◽  
Hyuk-Jae Chang ◽  
Reza Arsanjani ◽  
James K. Min ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Atherosclerosis Progression ◽  
Coronary Artery Atherosclerosis

Increased Superoxide Anion Production by Platelets in Hypercholesterolemic Patients

2002 ◽  
Vol 87 (05) ◽  
pp. 796-801 ◽  
Author(s):  
Valerio Sanguigni ◽  
Pasquale Pignatelli ◽  
Daniela Caccese ◽  
Fabio Pulcinelli ◽  
Luisa Lenti ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Ldl Cholesterol ◽  
Experimental Studies ◽  
Human Platelets ◽  
Superoxide Anion Production ◽  
Cholesterol Lowering ◽  
Platelet Production ◽  
Cholesterol Levels ◽  
Anion Production ◽  
O2 Production

SummaryThe purpose of this study was to investigate the relationship between hypercholesterolemia and superoxide anion production.Experimental studies demonstrated that hypercholesterolemia is associated with enhanced cellular superoxide anion (O2 −) production. Aim of the study was to assess whether the same phenomenon occurs in humans.Lipid profile and platelet O2 − production were measured in 28 patients with hypercholesterolemia, compared with 25 age- and sexmatched healthy subjects, and in 21 out of the 28 patients after 8-week treatment with 10 mg/day atorvastatin (a HMGCoA reductase inhibitor). In order to assess the mechanism by which LDL cholesterol interferes with platelet production of O2 −, human platelets were incubated with LDL cholesterol in the presence of either an inhibitor of the phospholipaseA2 enzyme, AACOCF3, or an inhibitor of NADH/NADPH oxidases, DPI.O2 − platelet generation was significantly higher (p <0.001) and significantly related to LDL cholesterol (p < 0.001 ) in patients as compared to controls. 8-week treatment with 10 mg/day atorvastatin significantly reduced both LDL cholesterol and O2 − platelet production. This effect was partially related to the cholesterol-lowering, in that three days of treatment with atorvastatin significantly decreased platelet O2 − production, while no significant change in LDL-cholesterol levels was observed. Platelets incubated with LDL cholesterol showed O2 − release by atorvastatin is partially related to cholesterol lowering effect, suggesting that other mechanisms could be responsible for the antioxidant activity of the drug.

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