4P-0939 Natural polyamines inhibit adhesion of human peripheral blood mononuclear cells to human umbilical vein endothelial cells by suppressing LFA-1

2003 ◽  
Vol 4 (2) ◽  
pp. 280
Author(s):  
K. Soda ◽  
Y. Kano ◽  
H. Ueba ◽  
M. Kawakami ◽  
F. Konishi
Keyword(s):  
Endothelial Cells ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Umbilical Vein ◽  
Peripheral Blood Mononuclear ◽  
Human Umbilical Vein ◽  
Blood Mononuclear Cells ◽  
Umbilical Vein Endothelial Cells

Echinomycin Suppresses the Pyrogenic Effects of Endotoxin and Interleukin- lβ in Human Endothelial Cells and Peripheral Blood Mononuclear Cells

1996 ◽  
Vol 75 (02) ◽  
pp. 359-362 ◽  
Author(s):  
Jean-Marc Herbert ◽  
Alain Lalé ◽  
Jean-Marie Pereillo ◽  
Jean-Marie Derocq ◽  
Pierre Casellas
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Intercellular Adhesion Molecule ◽  
Dependent Manner ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

SummaryEndotoxin (LPS) and interleukin-1(3 (IL-iβ) increased in a dose-dependent manner the expression of tissue factor, an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation at the surface of human umbilical vein endothelial cells (HUVEC) and human peripheral blood mononuclear cells (PBMC). Echinomycin, a cyclic octapeptide of microbial origin strongly inhibited LPS- and IL-1β-induced tissue factor expression in HUVEC and PBMC with IC50 values in the subnanomolar range at the same time it reduced LPS and IL-iβ-induced expression of intercellular adhesion molecule-1 (ICAM-1, CD54) on HUVEC (IC50 = 0.4 ± 0.1 and 0.3 ± 0.2 nM respectively). Echinomycin also reduced LPS-induced secretion of IL-iβ and IL-6 by human PBMC (IC50 = 10 ± 2 and 3 ± 0.5 nM respectively). These observations demonstrate that echinomycin protects endothelial cells and PBMC from the pyrogenic effect of LPS and 1β.

THRB expression is affected by miR-26a and miR-496, but age-associated decrease of the expression of this gene in human peripheral blood mononuclear cells is not dependent on these miRNAs

2014 ◽  
Author(s):  
Eliza Pawlik-Pachucka ◽  
Monika Budzinska ◽  
Anna Domaszewska-Szostek ◽  
Magdalena Owczarz ◽  
Magdalena Gewartowska ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Hyperglycemia Activates the CD27-CD70 Axis on Human Peripheral Blood Mononuclear Cells

2020 ◽  
pp. ascls.119.002089
Author(s):  
Claire Owaja ◽  
Evelyn Roback-Navarro ◽  
Naomi Iwai ◽  
Nadine Lerret
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Immunomodulatory Effects of Lactic Acid Bacteria on Human Peripheral Blood Mononuclear Cells

2003 ◽  
Vol 15 (4) ◽  
Author(s):  
J. Michalkiewicz ◽  
M. Krotkiewski ◽  
L. Gackowska ◽  
M. Wyszomirska-Golda ◽  
A. Helmin-Basa ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Immunomodulatory Effects ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells
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