Abstract: P1286 THE ROLE OF LIPOPROTEIN LIPASE ACTIVITY, HYPERINSULINEMIA AND FREE FATTY ACIDS IN GENESIS OF DYSLIPIDEMIAS

2009 ◽  
Vol 10 (2) ◽  
pp. e1342
Author(s):  
E Ageeva ◽  
Y Frolova ◽  
A Denisenko
1961 ◽  
Vol 201 (5) ◽  
pp. 915-922 ◽  
Author(s):  
B. Shore ◽  
V. Shore

The enzymes released into both human and rabbit plasmas by heparin injection hydrolyzed, in addition to triglyceride moieties of lipoproteins, a number of mono- and diglycerides of C16 and C18 fatty acids after in vitro addition of the unemulsified glycerides to the plasma. In human postheparin plasma, these enzymes also hydrolyzed glycerides of butyric and caproic acids. The pure triglycerides and methyl or ethyl esters of C16 and C18 fatty acids were not substrates. The heparin-released activities for the hydrolysis of glycerides added in vitro persisted after all activity for the lipolysis of lipoproteins had been destroyed by heat. These activities also differed from lipoprotein lipase activity with respect to the effects of 1 m NaCl, dialysis, and aging the plasma at 4 C. It appears that heparin releases into the blood more than one enzyme or more than one form of an enzyme which may be involved in a stepwise degradation to fatty acids and glycerol of the triglyceride moieties of lipoproteins of density less than 1.007 g/ml.


2009 ◽  
Vol 54 (4) ◽  
pp. 543-550 ◽  
Author(s):  
Iwona Rudkowska ◽  
Dominique Caron-Dorval ◽  
Mélanie Verreault ◽  
Patrick Couture ◽  
Yves Deshaies ◽  
...  

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