Conditioning of Immune Reactions

2010 ◽  
pp. 131-144 ◽  
Author(s):  
Laura Y. Gorczynski ◽  
Reginald M. Gorczynski
Keyword(s):  
Immune Reactions

Immune Reactions

1995 ◽  
Author(s):  
H.-Harald Sedlacek ◽  
Tarik Möröy
Keyword(s):  
Immune Reactions

Features of antibodies against benzo[a]pyrene formation in workers of coal mines and thermal power plants

2019 ◽  
pp. 9-14
Author(s):  
Ye. G. Polenok ◽  
S. A. Mun ◽  
L. A. Gordeeva ◽  
A. A. Glushkov ◽  
M. V. Kostyanko ◽  
...  
Keyword(s):  
Power Plant ◽  
Thermal Power Plant ◽  
Power Plants ◽  
Reference Group ◽  
Coal Dust ◽  
Thermal Power ◽  
Coal Mines ◽  
Serum Levels ◽  
Thermal Power Plants ◽  
Immune Reactions

Introduction.Coal dust and coal fi ring products contain large amounts of carcinogenic chemicals (specifically benz[a]pyrene) that are different in influence on workers of coal mines and thermal power plants. Specific immune reactions to benz[a]pyrene therefore in these categories of workers can have specific features.Objective.To reveal features of antibodies specifi c to benz[a]pyrene formation in workers of coal mines and thermal power plants.Materials and methods.The study covered A and G class antibodies against benz[a]pyrene (IgA-Bp and IgG-Bp) in serum of 705 males: 213 donors of Kemerovo blood transfusion center (group 1, reference); 293 miners(group 2) and 199 thermal power plant workers (group 3). Benz[a]pyrene conjugate with bovine serum albumin as an adsorbed antigen was subjected to immune-enzyme assay.Results.IgA-Bp levels in the miners (Me = 2.7) did not differ from those in the reference group (Me = 2.9), but in the thermal power plant workers (Me = 3.7) were reliably higher than those in healthy men and in the miners (p<0.0001). Levels of IgG-Bp in the miners (Me = 5.0) appeared to be lower than those in the reference group (Me = 6.4; (p = 0.05). IgG-Bb level in the thermal power plantworkers (Me = 7.4) exceeded the parameters in the healthy donors and the miners (p<0.0001). Non-industrial factors (age and smoking) appeared tohave no influence on specific immune reactions against benz[a]pyrene in the miners and the thermal power plant workers.Conclusions.Specific immune reactions against benz[a]pyrene in the miners and the thermal power plant workers are characterized by peculiarities: the miners demonstrate lower levels of class A serum antibodies to benz[a]pyrene; the thermal power plant workers present increased serum levels of class G antibodies to benz[a]pyrene. These peculiarities result from only the occupational features, but do not depend on such factors as age, smoking and length of service at hazardous production. It is expedient to study specific immune reactions to benz[a]pyrene in workers of coal mines and thermal power plants, to evaluate individual oncologic risk and if malignancies occur.

scholarly journals Revaccination as a measure of immunity to smallpox

1944 ◽  
Vol 43 (5) ◽  
pp. 337-340 ◽  
Author(s):  
E. S. Horgan ◽  
Mansour Ali Haseeb
Keyword(s):  
Experimental Work ◽  
Diagnostic Method ◽  
Sufficient Accuracy ◽  
Variola Virus ◽  
Elementary Body ◽  
High Potency ◽  
Insertion Technique ◽  
Immune Reactions ◽  
Full Immunity

1. Serological methods for the determination of smallpox immunity are briefly discussed, and it is concluded that they are unlikely to provide a diagnostic method of sufficient accuracy.2. Experimental work is recorded which shows certain differences in the response of previously vaccinated individuals, revaccinated simultaneously with a standard vaccine lymph and an elementary body suspension (vaccinia) of high potency. The significance of these differences is discussed.3. The results indicate that although the advantage of the e.b. suspension over vaccine lymph is relatively insignificant, that of two insertions over one is very marked. In revaccination the routine use of one insertion only may result in a certain number of semi-immunes (vaccinoids) being erroneously reported as immunes.4. It is concluded that if the two insertion technique be practised, persons showing immune reactions (negatives) may be considered, in all probability, as possessing full immunity to vaccinia-variola virus.

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