Predictive value of urethal frozen section during radical cystectomy for bladder cancer: to detect and prevent urethral recurrence

2002 ◽  
Vol 1 (1) ◽  
pp. 137
Author(s):  
Henry Botto ◽  
Michel Barbagelatta ◽  
Vincent Molinié ◽  
Philippe Barré ◽  
Jean-Marie Hervé ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Predictive Value ◽  
Frozen Section ◽  
Urethral Recurrence

Are frozen-section examinations of ureteral margins required for all patients undergoing radical cystectomy for bladder cancer?

Urology ◽  
1989 ◽  
Vol 33 (6) ◽  
pp. 451-454 ◽  
Author(s):  
Douglas E. Johnson ◽  
Kenneth I. Wishnow ◽  
Denise Tenney
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Frozen Section

Evaluation of (18F) FDG-PET-CT for preoperative lymph-node staging of bladder cancer.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 275-275 ◽  
Author(s):  
Julius van Essen ◽  
Joachim Grosse ◽  
David J. K. P. Pfister ◽  
Robin Epplen ◽  
Axel Heidenreich
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Radical Cystectomy ◽  
Predictive Value ◽  
Fdg Pet ◽  
Preoperative Staging ◽  
Lymph Node Staging ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Locoregional Staging

275 Background: Radical cystectomy with extended pelvic lymphadenectomy (EPLA) is the treatment of choice for muscle-invasive bladder cancer. For preoperative staging computed tomography and magnetic resonance imaging of the abdomen and the small pelvis are most commonly used in daily routine.Since the aforementioned methods, have a low sensitivity to detect local lymph node metastasis (LNM) we have prospectively evaluated the role of FDG – PET/CT for locoregional staging. Methods: In 27 patients (n = 27) with known invasive urothelial carcinoma or squamous cell carcinoma of the bladder a staging FDG – PET - CT was performed 1-2 days prior to radical cystectomy with EPLA. Subsequently, the results of the histopathological work-up of lymph node specimens and their anatomical localisations were correlated to the FDG-PET/CT findings. Total of 452 lymph nodes were removed, on average ≈ 16.7 per patient. Results: In 3/27 (11.1%) patients LNM were detected in histopathology. 2 patients showed one positive lymph node, 1 patient had two LNM. In two of these patients, the FDG-PET/CT showed an increased enrichment of FDG in projection to the corresponding histologically positive LN. One false negative and one false positive result of FDG-PET/CT were found. Calculated based on the patient population, the following statistics were calculated: Sensitivity (SENS) 66%, specificity (SPEC) 95.8%, positive predictive value (PPV) 66%, negative predictive value (NPV) 95.8%. Related to the absolute number of LN (n = 452), the following numbers were calculated: SENS 75% SPEC 98.7, PPV 37.5%, NPV 99.7%. Conclusions: To date, few studies have been conducted with regard to FDG-PET/CT and its role in locoregional staging. The reported specificity and NPV was between 86% and 100%, sensitivity and PPV were between 50% and 100%. Our results demonstrate specificity and NPV values of larger than 90% and make FDG-PET/CT a valuable staging tool to potentially identify patients with negative nodes in whom EPLA could be safely ommitted. Curently, routine use of PET CT scans can not be recommended and it is currently tested in a prospective multicenter study including a larger patient cohort.

The role of prostatic urethral biopsies as a staging tool for bladder cancer

2016 ◽  
Vol 10 (4) ◽  
pp. 359-363
Author(s):  
Adam W Nelson ◽  
Richard A Parker ◽  
Karan Wadhwa ◽  
Alexandra J Colquhoun ◽  
William H Turner
Keyword(s):  
Bladder Cancer ◽  
Positive Predictive Value ◽  
Retrospective Review ◽  
Predictive Value ◽  
Frozen Section ◽  
Prostatic Urethra ◽  
Published Data ◽  
Apical Margin ◽  
Single Centre

Objective: To determine the incidence of prostatic urethral involvement in our patient population and how prostatic urethral biopsy correlates with final cystectomy pathology. Patients and methods: We conducted a retrospective review of prostatic urethral biopsies (PUB) performed between February 2008 and April 2012 in a single centre. PUB pathology was correlated with cystectomy pathology. Results: PUB was undergone by 172 patients with a median age of 70 years (range: 37–84 years): There were 35 (20%) patients having a positive PUB and 137 (80%) who were negative. Of the 94 patients who underwent cystectomy, we found that when the entire prostatic urethra was sectioned, 20 (21%) patients had cancer in the prostatic urethra. Cancer was found in 17 (77%) of 22 patients with a positive PUB and in three (4%) out of the 72 with a negative PUB (positive predictive value (PPV) 77%, negative predictive value (NPV) 96%, sensitivity 85% and specificity 93%). In all 94 patients, the prostatic apical margin was negative. Conclusion: Disease in the prostatic urethra affected 20% of patients, consistent with published data. Prostatic urethral apical margins were all negative. Intra-operative frozen section would have missed cancer in the 20 patients with prostatic urethral cancer, whereas PUB identified 17 (85%) of the 20 patients. These data confirm the value of using PUB before cystectomy, in our UK population.

Accuracy of urethral frozen section during radical cystectomy for bladder cancer

2016 ◽  
Vol 34 (12) ◽  
pp. 532.e1-532.e6 ◽  
Author(s):  
Max Kates ◽  
Mark W. Ball ◽  
Meera R. Chappidi ◽  
Alex S. Baras ◽  
Jennifer Gordetsky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Frozen Section

scholarly journals Predictive value of prognostic nutritional index and systemic immune‐inflammation index on tumor progression in bladder cancer patients with after radical cystectomy

2020 ◽  
Author(s):  
Jiatong Zhou ◽  
Xitong Xu ◽  
RanLu Liu
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Predictive Value ◽  
Cox Regression ◽  
Prognostic Nutritional Index ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Nutritional Index ◽  
Immune Inflammation ◽  
Muscle Invasive

Abstract OBJECTIVES: The purpose of this study was to explore the predictive value of preoperative prognostic nutritional index(PNI) and systemic immune‐inflammation index(SII) for local tumor stage in bladder cancer(BC) after radical cystectomy(RC).METHODS: We researched our database between April 2011 and October 2019. There were 195 BC patients who underwent RC. The PNI and SII were calculated using preoperative blood sample results. The predictive value of SII and PNI was analysed with univariate and multivariate Cox regression models. Receiver operating characteristic (ROC) was used to determine the optimum PNI. Signifcant P was P<0.05.RESULTS: Of patients, all patients were males with a mean age of 67.94±8.97years. Mean serum albumin was 42.13±4.28(g/L), mean PNI score was 51.29±6.09 and mean SII was 661.67±506.22. Multivariable Cox regression analysis demonstrated that PNI scores and SII could not play a significantly predictive factor between muscle invasive bladder cancer(MIBC) and non-muscle-invasive bladder cancer(NMIBC). While we also found PNI was an independent risk factors for predicting tumor stagep(pT＜3a and pT≥3a).CONCLUSIONS: Our research revealed that preoperative low PNI but not SII could be used as an independent factor to predict worse pathologically stage(pT≥3a). But preoperative PNI and SII might not were significantly related with the incidence risk of muscle invasive. We still need future studies with large cohorts to identify our results.

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