SURVIVAL FOLLOWING CYSTECTOMY FOR PRIMARY MUSCLE INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA VERSUS INVASION ON TOP OF SUPERFICIAL DISEASE

2006 ◽  
Vol 5 (2) ◽  
pp. 24 ◽  
Author(s):  
B. Ali-el-Dein ◽  
M. Abdel-Latif ◽  
A. Mosbah ◽  
A. Shaaban ◽  
A. Nabeeh ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive

STRUCTURAL ALTERATION OF p53 PROTEIN IN PATIENTS WITH MUSCLE INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA

2001 ◽  
Vol 166 (6) ◽  
pp. 2155-2160 ◽  
Author(s):  
RABI TIGUERT ◽  
FERNANDO J. BIANCO ◽  
PETER OSKANIAN ◽  
YIWEI LI ◽  
DAVID J. GRIGNON ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
P53 Protein ◽  
Transitional Cell ◽  
Structural Alteration ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive

STRUCTURAL ALTERATION OF p53 PROTEIN IN PATIENTS WITH MUSCLE INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA

2001 ◽  
pp. 2155-2160
Author(s):  
RABI TIGUERT ◽  
FERNANDO J. BIANCO ◽  
PETER OSKANIAN ◽  
YIWEI LI ◽  
DAVID J. GRIGNON ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
P53 Protein ◽  
Transitional Cell ◽  
Structural Alteration ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive

scholarly journals Proteomics research on muscle-invasive bladder transitional cell carcinoma

2011 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
Hai Niu ◽  
Zhen Dong ◽  
Gang Jiang ◽  
Ting Xu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Bladder Transitional Cell Carcinoma ◽  
Proteomics Research ◽  
Muscle Invasive

scholarly journals Evaluation of β-Catenin in Bladder Transitional Cell Carcinoma

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
T M Elzayat ◽  
M I Shaban ◽  
A I Radwan ◽  
H Z Elwardany
Keyword(s):  
Bladder Cancer ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Carcinoma ◽  
Transitional Cell ◽  
Diagnostic Tools ◽  
Bladder Transitional Cell Carcinoma ◽  
Lymphnode Metastasis ◽  
Significant Difference ◽  
Muscle Invasive

Abstract Background Bladder cancer is the fourth most common cancer occurring in United States, second most prevalent cancer in men and tenth most prevalent cancer in women, with age adjusted incidence rate of 24.5 per 100.000 population and mortality rate of 4.2 per 100.000 population per year Because of its high recurrence rate, the actual prevalence of active bladder cancer is estimated to be about 10 times the number of new cases. Aim of the Work This study aims at investigating β-catenin protein expression in bladder transitional cell carcinoma and its possible relation to the clinic-pathological data. Patients and Methods The study was carried out on 80 patients; 60 patients with urothelial Bladder Carcinoma (UBC) and 20 patients with non-malignant lesions (control group); between May 2015 and May 2017. The 60 UBC cases were further divided, according to histopathological criteria, into non-muscle invasive UBC (30 patients) and muscle invasive UBC (30 patients). Results There was a highly a significant difference between β-catenin expression and tumor grade (P = 0.03) ,lymphnode metastasis (P = 0.005), tumor necrosis (P = 0.001) vascular invasion(P = 0.004), and perineural invasion (P = 0.001) No statistical significant relation was found between β-catenin expression either bilharziasis (P = 0.08) ,muscl invasion (p = 0.54) ,or stage (p = 0.7). Conclusion 1-β-Catenin has a role in carcinogenises of UB due to absence of nucleocytoplasmic pattern of β-catenin expression in non- neoplastic cases with its expression in a considerable number of invasive malignant cases and dysplastic urothelium adjacent to carcinoma could refer to the oncogenic role of this expression pattern. Recommendations Further studies on large number of cases of urothelial carcinoma on a longer period of follow up using more accurate diagnostic tools is recommended to elicit the predictive value of these markers on patients’ survival; also further studies on new therapies that target β-catenin or other component of Wnt pathway to detect its efficacy in preventing tumor recurrence or progression especially in non-muscle invasive bladder carcinoma.

1243: Survival Following Cystectomy for Primary Muscle Invasive Bladder Transitional Cell Carcinoma versus Invasion on Top of Superficial Disease

2006 ◽  
Vol 175 (4S) ◽  
pp. 400-400
Author(s):  
Bedeir Ali-El-dein ◽  
Mohamed Abdel-Latif ◽  
Ahmed Mosbah ◽  
Atallah A. Shaaban ◽  
Adel Nabeeh ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive
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