S149 HYDRONEPHROSIS IS AN INDEPENDENT PREDICTOR OF LYMPH NODE INVOLVEMENT IN MUSCLE-INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA

2010 ◽  
Vol 9 (6) ◽  
pp. 595
Author(s):  
M.A. Abbasi ◽  
K. Kamali ◽  
M. Akhlaghkhah ◽  
Y. Farokhi-Khajeh-Pasha ◽  
A. Abbasi
Keyword(s):  
Lymph Node ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Independent Predictor ◽  
Transitional Cell ◽  
Lymph Node Involvement ◽  
Bladder Transitional Cell Carcinoma ◽  
Node Involvement ◽  
Muscle Invasive

scholarly journals Transitional cell carcinoma of the urinary bladder with regional lymph node involvement treated by cystectomy

Cancer ◽  
2003 ◽  
Vol 97 (10) ◽  
pp. 2425-2431 ◽  
Author(s):  
Igor Frank ◽  
John C. Cheville ◽  
Michael L. Blute ◽  
Christine M. Lohse ◽  
Ajay Nehra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Regional Lymph Node ◽  
Transitional Cell ◽  
Lymph Node Involvement ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

scholarly journals Retroperitoneal Lymph Nodes in Transitional Cell Carcinoma of the Kidney and Ureter

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Shilajit D. Kundu ◽  
Scott E. Eggener
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Lymph Node Involvement ◽  
Therapeutic Benefit ◽  
Cancer Specific Survival ◽  
Node Involvement ◽  
Node Metastases

The incidence of transitional cell carcinoma of the kidney and ureter is low and for that reason limited data exists regarding the appropriate management of regional retroperitoneal lymph nodes. Lymph node metastases have consistently been associated with an adverse prognosis. However, five-year cancer-specific survival following nephroureterectomy and lymphadenectomy for patients with lymph node involvement ranges from 0–39%, suggesting a therapeutic benefit. This review covers the primary tumor characteristics associated with lymph node involvement, imaging of the lymph nodes, as well as the rationale, role, patient selection, suggested anatomic templates, and technical considerations for lymphadenectomy.

Combined Effects of p53, p21, and pRb Expression in the Progression of Bladder Transitional Cell Carcinoma

2004 ◽  
Vol 22 (6) ◽  
pp. 1007-1013 ◽  
Author(s):  
Sunanda J. Chatterjee ◽  
Ram Datar ◽  
David Youssefzadeh ◽  
Ben George ◽  
Peter J. Goebell ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Node ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Combined Effects ◽  
Wild Type ◽  
Bladder Transitional Cell Carcinoma ◽  
Time To Recurrence ◽  
Group I

Purpose To determine the combined effects of p53, p21, and pRb alterations in predicting the progression of bladder transitional cell carcinoma. Patients and Methods p53, p21, and pRb expression was examined immunohistochemically on archival radical cystectomy samples from 164 patients with invasive or high-grade recurrent superficial transitional cell carcinoma (TCC; lymph node–negative, 117 patients; lymph node–positive, 47 patients). Median follow-up was 8.6 years. Based on percentage of nuclear reactivity, p53 was considered as wild-type (0% to 10%) or altered (> 10%); p21 was scored as wild-type (>10%) or altered (< 10%); and pRb status was considered wild-type (1% to 50%) or altered (0% or > 50%). Results As individual determinants, the p53, p21, and pRb status were independent predictors of time to recurrence (P < .001, P < .001, and P < .001, respectively), and overall survival (P < .001, P = .002, and P = .001, respectively). By examining these determinants in combination, patients were categorized as group I (no alteration in any determinant, 47 patients), group II (any one determinant altered, 51 patients), group III (any two determinants altered, 42 patients), and group IV (all three determinants altered, 24 patients). The 5-year recurrence rates in these groups were 23%, 32%, 57%, and 93%, respectively (log-rank P < .001), and the 5-year survival rates were 70%, 58%, 33%, and 8%, respectively (log-rank P < .001). After stratifying by stage, the number of altered proteins remained significantly associated with time to recurrence and overall survival. Conclusion This study suggests that alterations in p53, p21, and pRb act in cooperative or synergistic ways to promote bladder cancer progression. Examining these determinants in combination provides additional information above the use of a single determinant alone.

STRUCTURAL ALTERATION OF p53 PROTEIN IN PATIENTS WITH MUSCLE INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA

2001 ◽  
Vol 166 (6) ◽  
pp. 2155-2160 ◽  
Author(s):  
RABI TIGUERT ◽  
FERNANDO J. BIANCO ◽  
PETER OSKANIAN ◽  
YIWEI LI ◽  
DAVID J. GRIGNON ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
P53 Protein ◽  
Transitional Cell ◽  
Structural Alteration ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive

STRUCTURAL ALTERATION OF p53 PROTEIN IN PATIENTS WITH MUSCLE INVASIVE BLADDER TRANSITIONAL CELL CARCINOMA

2001 ◽  
pp. 2155-2160
Author(s):  
RABI TIGUERT ◽  
FERNANDO J. BIANCO ◽  
PETER OSKANIAN ◽  
YIWEI LI ◽  
DAVID J. GRIGNON ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
P53 Protein ◽  
Transitional Cell ◽  
Structural Alteration ◽  
Bladder Transitional Cell Carcinoma ◽  
Muscle Invasive
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