521 THE ROLE OF ADJUVANT TREATMENT STRATEGIES AFTER SURGERY FOR HIGH-RISK LOCALIZED PROSTATE CANCER

2009 ◽  
Vol 8 (4) ◽  
pp. 251
Author(s):  
M. Spahn ◽  
S. Joniau ◽  
P. Gontero ◽  
B. Tombal ◽  
J. Walz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Adjuvant Treatment ◽  
Treatment Strategies ◽  
Localized Prostate Cancer

631 ROLE OF RADICAL PROSTATECTOMY FOR HIGH-RISK LOCALIZED PROSTATE CANCER

2007 ◽  
Vol 6 (2) ◽  
pp. 180
Author(s):  
A. Matsubara ◽  
J. Teishima ◽  
H. Yasumoto ◽  
T. Usui ◽  
T. Nakamoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Localized Prostate Cancer

scholarly journals Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer

2021 ◽  
Author(s):  
Alok K. Tewari ◽  
Alexander T.M. Cheung ◽  
Jett Crowdis ◽  
Jake R. Conway ◽  
Sabrina Y. Camp ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Clinical Outcomes ◽  
Copy Number ◽  
Residual Disease ◽  
Treatment Strategies ◽  
Localized Prostate Cancer ◽  
Copy Number Loss ◽  
Molecular Features ◽  
Pre Treatment

ABSTRACTHigh-risk localized prostate cancer (HRLPC) is associated with a substantial risk of recurrence and prostate cancer-specific mortality1. Recent clinical trials have shown that intensifying anti-androgen therapies administered prior to prostatectomy can induce pathologic complete responses (pCR) or minimal residual disease (MRD) (<5 mm), together termed exceptional response, although the molecular determinants of these clinical outcomes are largely unknown. Here, we performed whole exome (WES) and whole transcriptome sequencing (RNA-seq) on pre-treatment multi-regional tumor biopsies from exceptional responders (ER: pCR and MRD patients) and non-responders (NR: pathologic T3 or lymph node positive disease) treated with intensive anti-androgen therapies prior to prostatectomy. SPOP mutation and SPOPL copy number loss were exclusively observed in ER, while TP53 mutation and PTEN copy number loss were exclusively observed in NR. These alterations were clonal in all tumor phylogenies per patient. Additionally, transcriptional programs involving androgen signaling and TGFβ signaling were enriched in ER and NR, respectively. The presence of these alterations in routine biopsies from patients with HRLPC may inform the prospective identification of responders to neoadjuvant anti-androgen therapies to improve clinical outcomes and stratify other patients to alternative biologically informed treatment strategies.

Re: The Role of Surgery in High-risk Localized Prostate Cancer

2014 ◽  
Vol 66 (2) ◽  
pp. 387-389
Author(s):  
Hendrik Van Poppel
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Localized Prostate Cancer

scholarly journals Role of surgery in high-risk localized prostate cancer

2010 ◽  
Vol 17 (0) ◽  
Author(s):  
N. Lawrentschuk ◽  
G. Trottier ◽  
C. Kuk ◽  
A. R. Zlotta
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Localized Prostate Cancer
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