Petr Dmitriyevich Shabanov
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Irina Viktorovna Zarubina
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Eugenii Viktorovich Mokrenko
The analysis of literatural and proper experimental data on toxicology and pharmacology of trekrezan, a new synthetic immune modulator and adaptogenic, is reviewed. The data on acute and chronic toxicity as well as phamacodynamic effects of trekrezan and molecular mechanisms of its action are observed. The main attention is paid to study adaptogenic, immune stimulating and anti-inflammatory properties of trekrezan (effect on cell and humoral immunity, phagocytosis, interferonogenesis). The special part describes the influence of trekrezan and combination on its basis (with polyoxidonium, metaprot) on structural, metabolic and immunological changes in the lung and blood lymphocytes of rats in acune bronchopulmonary inflammation, experimental prostatitis and gingivitis. In conclusion, a schedule illustrating connections between pharmacodynamic effects and systemic and molecular mechanisms is analysed.
Pharmacology of trekrezan, a new immune modulator and adaptogenic