507 Low apparent diffusion coefficient (ADC) value is associated with biochemical recurrence in high risk prostate cancer patients

2016 ◽  
Vol 15 (3) ◽  
pp. e507
Author(s):  
J. Park ◽  
M.Y. Yoon ◽  
J.K. Kim ◽  
H.S. Kim ◽  
C.W. Jeong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
High Risk ◽  
Apparent Diffusion Coefficient ◽  
Cancer Patients ◽  
Biochemical Recurrence ◽  
Adc Value ◽  
High Risk Prostate Cancer ◽  
Apparent Diffusion ◽  
Risk Prostate Cancer

High-risk prostate cancer: factors predicting biochemical recurrence after radical prostatectomy

2015 ◽  
Vol 22 (3) ◽  
pp. 161-168
Author(s):  
Albertas Ulys ◽  
Agnė Ulytė ◽  
Pavel Dziameshka ◽  
Oleg Sukonko ◽  
Sergei Krasny ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Biochemical Recurrence ◽  
Perineural Invasion ◽  
Surgical Margins ◽  
T Stage ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Background/objective. Predictive criteria are needed to evaluate the risk of disease progression after radical prostatectomy. Such criteria would help to select patients most likely to benefit from adjuvant or multimodality treatment. Our aim was to identify predictive factors for biochemical recurrence among the  pre- and post-operative parameters in high-risk prostate cancer patients after radical prostatectomy. Methods. Data on high-risk prostate cancer patients between 2005 and 2009 were retrospectively reviewed in two cancer centers: National Cancer Institute, Vilnius, Lithuania, and N.  N.  Alexandrov National Cancer Centre of Belarus, Minsk, Belarus. 199 patients were selected for the  study. The  pre-operative independent variables were T stage, pretreatment PSA level and Gleason score. Surgical margins and perineural invasion were additionally known for 122 patients. The outcomes measured were biochemical recurrence free and overall survival. The mean follow-up time was 5.8 years. Results. Lower T stage (p = 0.001) and pretreatment PSA (p = 0.0001) were associated with better survival. In the multivariate analysis of pre-operative factors, high T stage (p = 0.008) and pretreatment PSA (p = 0.009) were predictive of biochemical recurrence. When postoperative parameters were included in the multivariate analysis, only pretreatment PSA (p = 0.01), positive surgical margins (p = 0.003) and perineural invasion (p = 0.03) remained relevant independent predictors of biochemical recurrence. Conclusions. Pretreatment PSA, positive surgical margins and perineural invasion were independent predictors of biochemical recurrence after radical prostatectomy in high-risk prostate cancer patients, while the  T stage became insignificant after adjusting for postoperative parameters.

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