OC.18.1 ARE ALL PATIENTS WITH HISTOLOGICAL DIAGNOSIS OF ATROPHIC GASTRITIS REALLY AT RISK OF DEVELOPING GASTRIC CANCER? ASSESSMENT OF GASTRIC ACID PRODUCTION BY CORRELATION BETWEEN MAXIMAL ACID OUTPUT AND PEPSINOGEN I

2014 ◽  
Vol 46 ◽  
pp. S38-S39
Author(s):  
F. Di Mario ◽  
H.P. Farkas ◽  
N. Dal Bò ◽  
F. Ferrara ◽  
T. Slongo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
At Risk ◽  
Atrophic Gastritis ◽  
Gastric Acid ◽  
Acid Production ◽  
Acid Output ◽  
Histological Diagnosis ◽  
Pepsinogen I ◽  
Maximal Acid Output

Individual Assessment of Gastric Acid Production by Means of a Non-Invasive Test: Relationship between Maximal Acid Output and Pepsinogen I Levels

2017 ◽  
Vol 152 (5) ◽  
pp. S471
Author(s):  
Francesco Di Mario ◽  
Serena Scida ◽  
Chiara Miraglia ◽  
Marilisa Franceschi ◽  
Renato Cannizzaro ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Acid Production ◽  
Acid Output ◽  
Pepsinogen I ◽  
Non Invasive ◽  
Invasive Test ◽  
Individual Assessment ◽  
Maximal Acid Output

scholarly journals Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development

2010 ◽  
Vol 59 (12) ◽  
pp. 1484-1489 ◽  
Author(s):  
Shinobu Imagawa ◽  
Masanori Ito ◽  
Masaharu Yoshihara ◽  
Hidetaka Eguchi ◽  
Shinji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Rank Test ◽  
Peptic Ulcers ◽  
Log Rank Test ◽  
H Pylori

Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1–30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated Helicobacter pylori duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P<0.05). dupA-positive H. pylori was detected not only in DU patients (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity in patients with dupA-positive H. pylori than in those with dupA-negative H. pylori (P<0.05). The occurrence of GCa was significantly lower in patients with dupA-positive H. pylori and a high BAO level (log-rank test P<0.05). DUs, higher acid output and dupA-positive H. pylori were negatively associated with GCa.

Significance of Serum Markers Pepsinogen I and II for Chronic Atrophic Gastritis, Peptic Ulcer, and Gastric Cancer

1993 ◽  
Vol 17 ◽  
pp. S146-S150 ◽  
Author(s):  
Norio Matsukura ◽  
Masahiko Onda ◽  
Akira Tokunaga ◽  
Itsuo Fujita ◽  
Takeshi Okuda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peptic Ulcer ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Serum Markers ◽  
Pepsinogen I

scholarly journals Accuracy of screening for gastric cancer using serum pepsinogen concentrations

Gut ◽  
1999 ◽  
Vol 44 (5) ◽  
pp. 693-697 ◽  
Author(s):  
F Kitahara ◽  
K Kobayashi ◽  
T Sato ◽  
Y Kojima ◽  
T Araki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Sensitivity And Specificity ◽  
Endoscopic Diagnosis ◽  
Screening Methods ◽  
Fundic Gland ◽  
Serum Pepsinogen ◽  
Pepsinogen I ◽  
Pepsinogen Ii ◽  
Receiver Operator Characteristics

BACKGROUND/AIMSThe characteristics of pepsinogen screening for gastric cancer were investigated to establish a suitable cut off point for identifying gastric cancer, using endoscopic diagnosis as the yardstick.SUBJECTS/METHODSSerum pepsinogen concentrations were measured in 5113 subjects who were also screened for gastric cancer by endoscopy. The cut off point for pepsinogen was determined using receiver operator characteristics curves.RESULTSThe most suitable cut off point was a pepsinogen I concentration of less than 70 ng/ml and a ratio of pepsinogen I to pepsinogen II of less than 3.0. Using this cut off point, the sensitivity and specificity of pepsinogen screening for gastric cancer were 84.6% and 73.5% respectively. All cases of gastric cancer in patients with severe atrophic gastritis were detected. However, two of four cases of gastric cancer in patients with mild atrophic gastritis were overlooked. In subjects with mild atrophic gastritis, when gastric cancer arises within the fundic gland region, the size of the lesion determines whether it is possible to detect cancer by serum pepsinogen screening.CONCLUSIONPepsinogen screening has many advantages, including its suitability for combination with other screening methods because it is simple and inexpensive.

scholarly journals Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese

Gut ◽  
1997 ◽  
Vol 41 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Y Kinoshita ◽  
C Kawanami ◽  
K Kishi ◽  
H Nakata ◽  
Y Seino ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acid Output ◽  
Pepsinogen I ◽  
The Past ◽  
Chronological Change ◽  
H Pylori ◽  
Japanese Subjects

Background—Gastric acid secretion in Japanese subjects decreases with aging. One of the possible causative mechanisms of this attenuated acid secretion is speculated to be aHelicobacter pylori induced chronic gastritis. The infection rate of this microorganism has decreased recently in Japan.Aims—To investigate whether gastric acid secretion has altered over the past 20 years, and if so, what the influence of H pylori infection might be in the Japanese population.Subjects and methods—Gastric acid secretion, serum gastrin and pepsinogen I and II concentrations, and H pylori infection were determined in 110 Japanese subjects in both the 1970s and 1990s.Results—Basal acid output as well as maximal acid output have greatly increased over the past 20 years, not only in individuals with H pylori infection but also in those without infection. Furthermore, subjects with H pyloriinfection tended to show decreased gastric acid secretion in comparison with those without infection, particularly in geriatric subjects. There was a positive correlation between gastric acid secretion and serum pepsinogen I concentrations.Conclusions—In Japan, both basal and stimulated gastric acid secretion have increased over the past 20 years; some unknown factors other than the decrease in H pylori infection may play an important role in this phenomenon.

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