094 Relationships between changes in time of quality of life and changes in time of the results of cardiopulmonary exercise test and echocardiography at a follow-up of patients with heart failure

2010 ◽  
Vol 2 (1) ◽  
pp. 32
Author(s):  
Leonidas Athanasopoulos ◽  
Athanasios Dritsas ◽  
Marianthi Tsakalou ◽  
Dennis Cokkinos
2017 ◽  
Author(s):  
Mary N. Woessner ◽  
Itamar Levinger ◽  
Christopher Neil ◽  
Cassandra Smith ◽  
Jason D Allen

BACKGROUND Chronic heart failure is characterized by an inability of the heart to pump enough blood to meet the demands of the body, resulting in the hallmark symptom of exercise intolerance. Chronic underperfusion of the peripheral tissues and impaired nitric oxide bioavailability have been implicated as contributors to the decrease in exercise capacity in these patients. nitric oxide bioavailability has been identified as an important mediator of exercise tolerance in healthy individuals, but there are limited studies examining the effects in patients with chronic heart failure. OBJECTIVE The proposed trial is designed to determine the effects of chronic inorganic nitrate supplementation on exercise tolerance in both patients with heart failure preserved ejection fraction (HFpEF) and heart failure reduced ejection fraction (HFrEF) and to determine whether there are any differential responses between the 2 cohorts. A secondary objective is to provide mechanistic insights into the 2 heart failure groups’ exercise responses to the nitrate supplementation. METHODS Patients with chronic heart failure (15=HFpEF and 15=HFrEF) aged 40 to 85 years will be recruited. Following an initial screen cardiopulmonary exercise test, participants will be randomly allocated in a double-blind fashion to consume either a nitrate-rich beetroot juice (16 mmol nitrate/day) or a nitrate-depleted placebo (for 5 days). Participants will continue daily dosing until the completion of the 4 testing visits (maximal cardiopulmonary exercise test, submaximal exercise test with echocardiography, vascular function assessment, and vastus lateralis muscle biopsy). There will then be a 2-week washout period after which the participants will cross over to the other treatment and complete the same 4 testing visits. RESULTS This study is funded by National Heart Foundation of Australia and Victoria University. Enrolment has commenced and the data collection is expected to be completed in mid 2018. The initial results are expected to be submitted for publication by the end of 2018. CONCLUSIONS If inorganic nitrate supplementation can improve exercise tolerance in patients with chronic heart failure, it has the potential to aid in further refining the treatment of patients in this population. CLINICALTRIAL Australian New Zealand Clinical Trials Registry ACTRN12615000906550; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368912 (Archived by WebCite at http://www.webcitation.org/6xymLMiFK)


2018 ◽  
Vol 24 (8) ◽  
pp. S124-S125 ◽  
Author(s):  
Md. Mobashir Hasan Shandhi ◽  
Joanna Fan ◽  
Alex J. Heller ◽  
Mozziyar Etemadi ◽  
Omer T. Inan ◽  
...  

2020 ◽  
Vol 9 (10) ◽  
pp. e1949108538
Author(s):  
Carina Akemi Chimada ◽  
Edilaine Martins da Silva ◽  
Joice Karina Otênio ◽  
Mariana Moraes Pinc ◽  
Renan Almeida de Jesus ◽  
...  

Heart failure is a chronic disease that compromises the patient's quality of life, due to its symptoms, such as: tiredness/fatigue, exercise intolerance, orthopnea, paroxysmal nocturnal dyspnea. The aim of the present study was to intervene and assist in the treatment of Heart Failure patient with pharmacological and non-pharmacological approaches in order to improve the quality of life and patient compliance regarding the existing disease. Pharmaceutical consultations were carried out over a seven-month period with a patient that suffers from Heart Failure, resident of Umuarama-PR, treated at home. The SOAP method was adopted for the registration of consultations for later analysis, and the measurement of blood pressure was performed by the patient, using the HBPM method. For the analysis of interactions, the Micromedex database and the patient’s package leaflet were used.The patient had a significant decrease in his BP with the follow-up; however, he showed resistance to going to the doctor. After some guidance, the patient agreed to go to the consultation and he was diagnosed with Renal Failure and Prostatic Hyperplasia. It is concluded that pharmaceutical care can be an effective alternative in obtaining better clinical results and helps to improve the patient's quality of life, since it can provide awareness of their health status and the need for the correct use of medications, making the most effective and safe treatment.


2012 ◽  
Vol 2 (5) ◽  
pp. 89-95
Author(s):  
Elias F. Porto ◽  
Claudia Kümpel ◽  
José R. Leite ◽  
Aline A. Andrade ◽  
Natália C. Oliveira ◽  
...  

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