448 Prognostic value of brain natriuretic peptide and an enhanced ventilatory response during cardiopulmonary exercise test in patients with heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 107-107
Author(s):  
A SCARDOVI ◽  
R DEMARIA ◽  
C COLETTA ◽  
S PERNA ◽  
N ASPROMONTE ◽  
...  
Keyword(s):  
Heart Failure ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Exercise Test ◽  
Prognostic Value ◽  
Ventilatory Response ◽  
Cardiopulmonary Exercise Test ◽  
Cardiopulmonary Exercise ◽  
Patients With Heart Failure

scholarly journals Effects of Dietary Inorganic Nitrate Supplementation on Exercise Performance in Patients With Heart Failure: Protocol for a Randomized, Placebo-Controlled, Cross-Over Trial (Preprint)

2017 ◽  
Author(s):  
Mary N. Woessner ◽  
Itamar Levinger ◽  
Christopher Neil ◽  
Cassandra Smith ◽  
Jason D Allen
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Test ◽  
Exercise Tolerance ◽  
Cardiopulmonary Exercise Test ◽  
Cardiopulmonary Exercise ◽  
Inorganic Nitrate ◽  
Patients With Heart Failure ◽  
Nitrate Supplementation ◽  
Nitric Oxide Bioavailability

BACKGROUND Chronic heart failure is characterized by an inability of the heart to pump enough blood to meet the demands of the body, resulting in the hallmark symptom of exercise intolerance. Chronic underperfusion of the peripheral tissues and impaired nitric oxide bioavailability have been implicated as contributors to the decrease in exercise capacity in these patients. nitric oxide bioavailability has been identified as an important mediator of exercise tolerance in healthy individuals, but there are limited studies examining the effects in patients with chronic heart failure. OBJECTIVE The proposed trial is designed to determine the effects of chronic inorganic nitrate supplementation on exercise tolerance in both patients with heart failure preserved ejection fraction (HFpEF) and heart failure reduced ejection fraction (HFrEF) and to determine whether there are any differential responses between the 2 cohorts. A secondary objective is to provide mechanistic insights into the 2 heart failure groups’ exercise responses to the nitrate supplementation. METHODS Patients with chronic heart failure (15=HFpEF and 15=HFrEF) aged 40 to 85 years will be recruited. Following an initial screen cardiopulmonary exercise test, participants will be randomly allocated in a double-blind fashion to consume either a nitrate-rich beetroot juice (16 mmol nitrate/day) or a nitrate-depleted placebo (for 5 days). Participants will continue daily dosing until the completion of the 4 testing visits (maximal cardiopulmonary exercise test, submaximal exercise test with echocardiography, vascular function assessment, and vastus lateralis muscle biopsy). There will then be a 2-week washout period after which the participants will cross over to the other treatment and complete the same 4 testing visits. RESULTS This study is funded by National Heart Foundation of Australia and Victoria University. Enrolment has commenced and the data collection is expected to be completed in mid 2018. The initial results are expected to be submitted for publication by the end of 2018. CONCLUSIONS If inorganic nitrate supplementation can improve exercise tolerance in patients with chronic heart failure, it has the potential to aid in further refining the treatment of patients in this population. CLINICALTRIAL Australian New Zealand Clinical Trials Registry ACTRN12615000906550; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368912 (Archived by WebCite at http://www.webcitation.org/6xymLMiFK)

scholarly journals Seismocardiography Can Assess Cardiopulmonary Exercise Test Parameters in Patients with Heart Failure

2018 ◽  
Vol 24 (8) ◽  
pp. S124-S125 ◽  
Author(s):  
Md. Mobashir Hasan Shandhi ◽  
Joanna Fan ◽  
Alex J. Heller ◽  
Mozziyar Etemadi ◽  
Omer T. Inan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Test ◽  
Cardiopulmonary Exercise Test ◽  
Cardiopulmonary Exercise ◽  
Test Parameters ◽  
Patients With Heart Failure
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