scholarly journals The Los Angeles Classification of Gastroesophageal Reflux Disease

2013 ◽  
Vol 1 (1) ◽  
pp. 103-104 ◽  
Author(s):  
SS Sami ◽  
K Ragunath
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Los Angeles Classification

Numerical modification of the Los Angeles classification of gastroesophageal reflux disease fails to decrease observer variation

2004 ◽  
Vol 16 (1) ◽  
pp. 9-11 ◽  
Author(s):  
Motoyasu Kusano ◽  
Sayaka Sugimoto ◽  
Osamu Kawamura ◽  
Keiko Minashi ◽  
Masaki Maeda ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Observer Variation ◽  
Los Angeles Classification

scholarly journals ENDOSCOPIC CHANGES RELATED TO GASTROESOPHAGEAL REFLUX DISEASE: COMPARATIVE STUDY AMONG BARIATRIC SURGERY PATIENTS

2015 ◽  
Vol 28 (suppl 1) ◽  
pp. 36-38 ◽  
Author(s):  
Marco Aurelio SANTO ◽  
Sylvia Regina QUINTANILHA ◽  
Cesar Augusto MIETTI ◽  
Flavio Masato KAWAMOTO ◽  
Allan Garms MARSON ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Hiatal Hernia ◽  
Barrett’S Esophagus ◽  
Reflux Disease ◽  
Barrett's Esophagus ◽  
Erosive Esophagitis ◽  
Los Angeles Classification ◽  
Bariatric Patients

Background : Obesity is correlated with several comorbidities, including gastroesophageal reflux disease. Its main complications are detectable by endoscopy: erosive esophagitis and Barrett's esophagus. Aim : To correlate erosive esophagitis and hiatal hernia with the degree of body mass index (BMI). Method : Was performed a retrospective analysis of 717 preoperative endoscopic reports of bariatric patients. Fifty-six (8%) presented hiatal hernia, being 44 small, nine medium and five large. Esophagitis was classified by Los Angeles classification. Results : There was no correlation between the presence and dimension of hiatal hernia with BMI. One hundred thirty-four (18.7%) patients presented erosive esophagitis. Among them, 104 (14.5%) had esophagitis grade A; 25 (3.5%) grade B; and five (0.7%) grade C. When considering only the patients with erosive esophagitis, 77.6% had esophagitis grade A, 18.7% grade B and 3.7% grade C. Were identified only two patients with Barrett's esophagus (0,28%). Conclusion : There was a positive correlation between the degree of esophagitis with increasing BMI.

scholarly journals Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy

2021 ◽  
Vol 31 (2) ◽  
pp. 46-53
Author(s):  
E. V. Barkalova ◽  
S. S. Pirogov ◽  
D. N. Andreev ◽  
M. A. Ovsepyan ◽  
I. V. Maev ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Diagnostic Techniques ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Barrett's Oesophagus ◽  
Los Angeles Classification ◽  
Main Challenge

Aim. A clinical description of gastroesophageal reflux disease (GERD) complicated by Barrett’s oesophagus (BO) at inadequate antisecretory therapy and the assessment of functional tests in control of conservative treatment.Key points. A 63-yo patient with no complaints in a proton pump inhibitor (PPI) therapy was admitted for a follow-up examination for BO-complicated GERD using oesophagogastroduodenoscopy (OGDS) with biopsy, high-resolution oesophageal manometry and 24-h pH-impedance. Endoscopy revealed signs of BO (long segment C1M3), erosive reflux oesophagitis (grade B in Los Angeles classification). Non-contractile oesophagus in manometry. Antisecretory therapy was stated ineffective and subject to correction in 24-h pH-impedance.Conclusion. Asymptomatic BO-complicated GERD patients comprise a special cohort. The main challenge to prevent progression into oesophageal adenocarcinoma is an adequate personalised patient management leveraging the modern diagnostic techniques, control of antisecretory treatment and its correction a situ.

scholarly journals Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Tawfik Khoury ◽  
Amir Mari ◽  
Hana Amara ◽  
Mohamed Jabaren ◽  
Abdulla Watad ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Pleiotropic Effect ◽  
Lipid Lowering ◽  
Control Group ◽  
Cross Sectional ◽  
Los Angeles Classification ◽  
The Impact

Background and Aims. We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease. In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common. Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. Nevertheless, the possible impact of statins in esophagitis development has never been assessed. Methods. We performed a retrospective, cross-sectional, single center study that included 4148 gastroesophageal reflux disease patients from 2014 and 2018 at EMMS Nazareth Hospital. We divided the patients into 5 groups. The groups were split into positive control group, which was the nonesophagitis group, and the other 4 groups were A-D (as per Los Angeles classification). Results. Overall, out of the 4148 patients included, 48% were males and 2840 patients were in the control group. In groups A, B, C, and D there were 818, 402, 72, and 16 patients, respectively. Logistic regression analysis revealed that chronic statins usage is protective by preventing development esophagitis (OR 0.463 [95%CI 0.370–0.579], p < 0.0001). NSAIDS use, Hiatus hernia, and H. pylori were promoting factors (OR, 1.362, 1.779, and 1.811; 95% CI, 1.183-1.569, 1.551-2.040, and 1.428-2.298; P<0.0001, P<0.0001, and P<0.0001, respectively). Conclusion. Using chronic statins was protective to the development of esophagitis among GERD patients. Our findings of potential clinical application mandate further randomized controlled trials to better assess the impact of statins on esophagitis.

The Italian validation of the Montreal Global definition and classification of gastroesophageal reflux disease

2009 ◽  
Vol 21 (4) ◽  
pp. 394-408 ◽  
Author(s):  
Fabio Pace ◽  
Franco Bazzoli ◽  
Roberto Fiocca ◽  
Francesco Di Mario ◽  
Vincenzo Savarino ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Italian Validation

scholarly journals Dysphagia in Gastroesophageal Reflux Disease (Gerd)

2014 ◽  
Vol 68 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Kalina Grivcheva-Stardelova ◽  
Rozalinda Popova-Jovanova ◽  
Gjorgji Deriban ◽  
Nenad Joksimovic ◽  
Milka Zdravkovska
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Odds Ratio ◽  
Healing Rate ◽  
Erosive Esophagitis ◽  
Response To Therapy ◽  
Alarm Symptom ◽  
Severe Grade

Abstract Introduction. Dysphagia is considered an alarm symptom, raising the question of stricture or malignancy. We sought to determine the prevalence and severity of dysphagia and correlation with severity of gastroesophageal reflux disease and its response to therapy. Methods. A total of 642 patients with endoscopically confirmed erosive esophagitis (Los Angeles grades AD). Esophagitis was classified as mild (grade A or B) or severe (grade C or D). Results. At baseline, of 642 patients 37% had dysphagia, 43% had severe esophagitis, and 35% mild esophagitis (odds ratio, 1.39; 95% confidence interval, 1.27-1.51, p<0.001). Dysphagia resolved in 73% of patients after 4 weeks of proton pump inhibitor (PPI) treatment. Resolution of dysphagia was associated with a mean healing rate of 87% acrossall treatments. Seventeen percent of patients reported persistent dysphagia, and in these patients the healing rates were decreased significantly (mean 72%; p<0.0001). Conclusions. Dysphagia is common in patients with erosive esophagitis but is not a reliable clinical predictor of severe erosive esophagitis. Dysphagia resolved with PPI therapy in most cases, but persistent dysphagia may indicate failed healing.

scholarly journals Semi-embedded Valve Anastomosis: A new anti-reflux anastomotic method after proximal gastrectomy for adenocarcinoma of the oesophagogastric junction

2020 ◽  
Author(s):  
Baohua Wang ◽  
Yupeng Wu ◽  
Haijun Wang ◽  
Haiqiang Zhang ◽  
Liting Wang ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux ◽  
Proximal Gastrectomy ◽  
Physiological Mechanism ◽  
Los Angeles Classification ◽  
Oesophagogastric Junction ◽  
Signed Rank ◽  
Laparoscopic Proximal Gastrectomy ◽  
New Type

Abstract Background: There is a high probability of gastroesophageal reflux after laparoscopic proximal gastrectomy for adenocarcinoma of the oesophagogastric junction (AEG). Various anti-reflux anastomotic methods are emerging in clinical practice; however, none of them have been widely accepted. We have innovated a new type of anti-reflux anastomotic method, named semi-embedded valve anastomosis. The aim of this study was to explore the feasibility and anti-reflux effect of the new anastomotic method.Methods: The clinical data of 28 patients with Siewert II AEG who were treated by semi-embedded valve anastomosis were collected. The key point of the operation is to reconstruct a simulated valve and form an anti-reflux barrier similar to the physiological mechanism. The gastroesophageal reflux disease questionnaire (GerdQ) and classification of gastroesophageal reflux under electron microscopy were used to evaluate gastroesophageal reflux after the operation.Results: The mean operative duration was 164.3±19.0 min, the median intraoperative haemorrhage volume was 65 ml, the average number of lymph nodes dissected was 23±2.6, the time for valve construction was 15.8±3.2 min, the time for anastomotic reconstruction was 35.4±4.8 min, the median time to first flatus was 3 d, and the median hospitalization duration was 12 d. There was one case of postoperative anastomotic stenosis. The GerdQ score [median (range)] was as follows: 2 (0-6), preoperation; 0 (0-8), 1 month postoperation; 2 (0-12), 3 months postoperation; and 3 (0-12), 6 months postoperation. The Wilcoxon signed-rank sum test was carried out at different times after the operation and the day before the operation, and the differences were not significant (P<0.05). There was one case of grade B gastroesophageal reflux according to the Los Angeles classification system among the gastrofibroscopic re-examination reports of 28 cases.Conclusion: Semi-embedded valve anastomosis is safe and feasible after proximal gastrectomy for Siewert II AEG and has good anti-reflux effects.

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