scholarly journals Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study

2019 ◽  
Vol 1 (1) ◽  
pp. e35-e44 ◽  
Author(s):  
Valentina Bellemo ◽  
Zhan W Lim ◽  
Gilbert Lim ◽  
Quang D Nguyen ◽  
Yuchen Xie ◽  
...  
PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179790 ◽  
Author(s):  
Hidenori Takahashi ◽  
Hironobu Tampo ◽  
Yusuke Arai ◽  
Yuji Inoue ◽  
Hidetoshi Kawashima

2020 ◽  
Vol 46 (7) ◽  
pp. 478-481 ◽  
Author(s):  
Joshua James Hatherley

Artificial intelligence (AI) is expected to revolutionise the practice of medicine. Recent advancements in the field of deep learning have demonstrated success in variety of clinical tasks: detecting diabetic retinopathy from images, predicting hospital readmissions, aiding in the discovery of new drugs, etc. AI’s progress in medicine, however, has led to concerns regarding the potential effects of this technology on relationships of trust in clinical practice. In this paper, I will argue that there is merit to these concerns, since AI systems can be relied on, and are capable of reliability, but cannot be trusted, and are not capable of trustworthiness. Insofar as patients are required to rely on AI systems for their medical decision-making, there is potential for this to produce a deficit of trust in relationships in clinical practice.


2020 ◽  
Vol 45 (12) ◽  
pp. 1550-1555
Author(s):  
Xiang-Ning Wang ◽  
Ling Dai ◽  
Shu-Ting Li ◽  
Hong-Yu Kong ◽  
Bin Sheng ◽  
...  

Nowadays, artificial intelligence applications invade all of the fields including medical applications field. Deep learning, a subfield of artificial intelligence, in particular, Convolutional Neural Networks (CNN), have quickly become the first choice for processing and analyzing medical images due to its performance and effectiveness. Diabetic retinopathy is a vision loss disease that infects people with diabetes. This disease damages the blood vessels in the retina, hence, leads to blindness. Due to the sensitivity and complications involved in managing diabetics, designing and developing automated systems to detect and grade diabetic retinopathy is considered one of the recent research areas in the world of medical image applications. In this paper, the aspects of deep learning field related to diabetic retinopathy have been discussed. Various concepts in deep learning including traditional Artificial Neural Network (ANN) algorithm, ANN drawbacks in context of computer vision and image processing applications, and the best algorithm to overcome ANN drawbacks, CNN, have been elucidated along with the architecture. The paper also reviews an extensive summary of some works in the current research trend and future applications of the DL algorithms in medical image analysis for DR detection and grading. Furthermore, various research gabs related to building such automated systems for medical image analysis have been conferred – such as imbalance dataset which is considered one of the main performance issues that should be handled, the need of high performance computational resources to train deep and efficient models and others. This is quite beneficial for researchers working in the domain of medical image analysis to handle DR.


2021 ◽  
Author(s):  
Aaron Y. Lee ◽  
Ryan T. Yanagihara ◽  
Cecilia S. Lee ◽  
Marian Blazes ◽  
Hoon C. Jung ◽  
...  

<b>Objective: </b>With rising global prevalence of diabetic retinopathy (DR), automated DR screening is needed for primary care settings. Two automated artificial intelligence (AI)-based DR screening algorithms have FDA approval. Several others are under consideration while in clinical use in other countries, but their real-world performance has not been evaluated systematically. We compared the performance of seven<b> </b>automated AI-based DR screening algorithms (including one FDA-approved algorithm) against human graders when analyzing real-world retinal imaging data. <p> </p> <p><b>Research Design and Methods: </b>This was a multicenter, non-interventional device validation study evaluating a total of 311,604 retinal images from 23,724 veterans who presented for teleretinal DR screening at the Veterans Affairs (VA) Puget Sound Health Care System (HCS) or Atlanta VA HCS from 2006 to 2018.<b> </b>Five companies provided seven algorithms, including one with FDA approval, that independently analyzed all scans, regardless of image quality. The sensitivity/specificity of each algorithm when classifying images as referable DR or not were compared to original VA teleretinal grades and a regraded arbitrated dataset. Value per encounter was estimated.</p> <p> </p> <p><b>Results: </b>Although high negative predictive values (82.72%-93.69%) were observed, sensitivities varied widely (50.98%-85.90%). Most algorithms performed no better than humans against the arbitrated dataset, but two achieved higher sensitivities and one yielded comparable sensitivity (80.47%, p = 0.441) and specificity (81.28%, p = 0.195). Notably, one had lower sensitivity (74.42%) for proliferative DR (p = 9.77x10<sup>-4</sup>) than the VA teleretinal graders. Value per encounter varied at $15.14-$18.06 for ophthalmologists and $7.74-$9.24 for optometrists.</p> <p> </p> <b>Conclusions</b>: The DR screening algorithms showed significant performance differences. These results argue for rigorous testing of all such algorithms on real-world data before clinical implementation.


Author(s):  
Valentina Bellemo ◽  
Zhan W Lim ◽  
Gilbert Lim ◽  
Quang D Nguyen ◽  
Yuchen Xie ◽  
...  

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